Safety and efficacy of delivering systemic treatments concomitantly with whole-brain radiotherapy: a prospective, observational, single-institution study
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Le résumé fourni par la source
Aim: The aim of our study was to evaluate the safety and efficacy of delivering systemic treatments concurrently with whole-brain radiotherapy (WBRT). Methods: A single-institution, prospective observational study was conducted in Athens, Greece, including 99 patients treated with WBRT for brain metastases from September 2017 until October 2019, and with a follow-up period extending to March 2025. The study endpoints included overall survival (OS) for all causes of death, time to intracranial progression (TTICP), and serious acute toxicities. Results: = 0.009) increased the risk of death for patients with brain metastases treated with whole brain radiotherapy. The median TTICP was 10 months (95% CI: 3.3-16.6), with a more protracted fractionation and a larger number of brain metastases being prognostic of an increase in the TTICP. Acute severe toxicity was observed in 16.2% of patients, with no statistically significant difference between concurrent and no systemic therapy groups, and with no treatment interruptions in patients treated concurrently. Conclusions: This study showed that there is no serious toxicity from the combination of systemic therapy with WBRT, and that the OS and the TTICP are not compromised with their concurrent delivery.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Safety and efficacy of delivering systemic treatments concomitantly with whole-brain radiotherapy: a prospective, observational, single-institution study
- Date Crossref
- 07/08/2026
- Éditeur
- Open Exploration Publishing
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National and Kapodistrian University of Athens Mediterraneo Hospital pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Ioannina pays non établi dans la noticeÉtablissement de santé
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Aretaeio Hospital pays non établi dans la noticeÉtablissement de santé
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Attikon University Hospital Department of Applied Medical Physics pays non établi dans la noticeUniversité ou école supérieure
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Mediterraneo Hospital Radiation Oncology and Stereotactic Radiosurgery Center pays non établi dans la noticeÉtablissement de santé
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Aretaieion University Hospital Oncology Unit pays non établi dans la noticeUniversité ou école supérieure
Mediterraneo Hospital — National and Kapodistrian University of Athens, University Hospital of Ioannina et Aretaeio Hospital, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.