Christos Papadimitriou

Fallopian Tube Cytology for Exploratory Detection of Adnexal Malignancy: Prospective Evaluation of the CytoSaLPs Score in an Ex Vivo Surgical Cohort

Victoria Psomiadou, Sofia Lekka, Theodoros Panoskaltsis, Abraham Pouliakis et autres

Objective: Ovarian, fallopian tube, and primary peritoneal cancers are the deadliest gynecological malignancies, largely due to delayed diagnosis, tumor heterogeneity, and lack of effective methods for early detection. Increasing evidence suggests that most high-grade serous ovarian carcinomas originate from the fallopian tube …

Safety and efficacy of delivering systemic treatments concomitantly with whole-brain radiotherapy: a prospective, observational, single-institution study

Maria Protopapa, Kalliopi Platoni, Michalis Psarras, Styliani-Theonymfi Nikoloudi et autres

Aim: The aim of our study was to evaluate the safety and efficacy of delivering systemic treatments concurrently with whole-brain radiotherapy (WBRT). Methods: A single-institution, prospective observational study was conducted in Athens, Greece, including 99 patients treated with WBRT for brain metastases …

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EP1733 - LBA_ECE_1473 - The role of pembrolizumab immunotherapy in metastatic adrenocortical carcinoma: a case series study

Kyriaki Gkoufa, Ariadni Spyroglou, Maria Theochari, Odysseas Violetis et autres

Abstract Background Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis in advanced stages. Standard first-line treatment for metastatic disease involves mitotane and cytotoxic chemotherapy (EDP-M); however, therapeutic options following progression are limited. Immunotherapy with immune checkpoint inhibitors, such …

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Lipid Profiles in Breast Cancer: Clinical Associations and Biological Insights

Anastasia Nikolakopoulou, Kalliopi Stavrati, Constantinos Nastos, Dimitrios Papaconstantinou et autres

Alterations in lipid metabolism are increasingly recognized as important contributors to breast cancer biology. Lipids regulate membrane structure, intracellular signaling, and energy homeostasis, and cancer cells undergo lipid metabolic reprogramming to support tumor growth and progression. This narrative review summarizes current evidence …

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Lipid and High-Density Lipoprotein (HDL) Subfraction Changes in Premenopausal and Postmenopausal Women With Breast Cancer Receiving Hormonal Therapy

Anastasia Nikolakopoulou, Constantinos Nastos, Dimitrios Papakonstantinou, Kalliopi E. Stavrati et autres

BACKGROUND AND AIM: Hormonal modulation therapy is an important component of hormone receptor-positive breast cancer treatment. However, the type and duration of hormonal therapies have distinct effects on lipid profile parameters and cardiovascular disease risk. This study aimed to investigate the impact …

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Plain language summary of results from the DUO-E study: durvalumab given with or without olaparib in patients with advanced endometrial cancer

Shannon N. Westin, Kathleen N. Moore, Hye Sook Chon, Jung-Yun Lee et autres

Plain Language SummaryWhat is this summary about?There are only a few current treatment options for people with newly diagnosed advanced or recurrent endometrial cancer (cancer that has returned). The DUO-E study is testing an immunotherapy, durvalumab, and a targeted therapy, olaparib, in …

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Detection of PD-L1 MRNA expression in circulating tumor cells (CTCS) from patients with metastatic NSCLC, HNSCC and melanoma using a novel highly sensitive commercially available CE-IVD KIT

Areti Strati, Martha Zavridou, Stavroula Smilkou, Victoria Tserpeli et autres

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Detection of hotspot PIK3CA mutations in primary tumors and plasma-cfDNA of breast cancer patients using a novel highly sensitive CE-IVD KIT

Stavroula Smilkou, Dimitra Stergiopoulou, Eleni Tzanikou, L Kaklamanis et autres

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SO-2 Prevalence and prognostic role of inherited germline mutations in cancer predisposing genes in unselected patients with pancreatic cancer

Elena Fountzilas, Alexia Eliades, Georgia-Angeliki Koliou, Achilleas Achilleos et autres

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Prognostic implications of mismatch repair deficiency in patients with early-stage colorectal and endometrial cancer

Eleni Fountzila, Vassiliki Kotoula, G. Pentherdoudakis, Kyriaki Manousou et autres

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Actionable mutations and overall survival in 3,211 patients with cancer: The Hellenic cooperative oncology group precision medicine initiative

Eleni Fountzila, Vassiliki Kotoula, Georgia-Angeliki Koliou, Eleni Giannoulatou et autres

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ARV7 status and CTC count: A combined biomarker for the baseline therapeutic decision in each line of mCRPC treatment

Evangelos Bournakis, Evi S. Lianidou, Areti D. Strati, Martha Zavridou et autres

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