The Effect of Prior Proton Pump Inhibitor Use on Gastric Cancer Survival: A Population-Based Cohort Study in the 5 Nordic Countries
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Le résumé fourni par la source
INTRODUCTION: Proton pump inhibitors (PPIs) might mask gastric cancer symptoms, leading to delayed diagnosis and worse oncological outcomes. However, current evidence is sparse and underpowered. This study aimed to elucidate whether PPI use influences oncological outcomes of gastric cancer in a well-powered study. METHODS: This population-based cohort study included individuals with gastric non-cardia adenocarcinoma from the 5 Nordic nations. Multiple nationwide registries provided prospectively collected data. The individuals were grouped into non-users, light users, or heavy PPI users during the 2-year period before diagnosis. The outcomes of 5-year disease-specific mortality (primary) and 5-year all-cause mortality were analyzed using Cox regression, providing hazard ratios (HR) with 95% confidence intervals (CI). The outcomes of metastatic disease and advanced tumor stage at diagnosis were analyzed using logistic regression, providing odds ratios (OR) with 95% CI. The risk estimates were adjusted for age, sex, country, year, comorbidity, and Helicobacter pylori treatment. RESULTS: Among 21,433 individuals with gastric non-cardia adenocarcinoma, there were 9,736 users and 11,697 non-users. Heavy and light PPI use were both associated with reduced risk of 5-year disease-specific mortality (adjusted HR = 0.90, 95% CI 0.86-0.94 and HR = 0.87, 95% CI 0.84-0.91, respectively), with similar results for 5-year all-cause mortality. Heavy PPI use was associated with decreased risks of presenting with metastatic disease (adjusted OR = 0.70, 95% CI 0.64-0.76) or advanced tumor stage (adjusted OR = 0.71, 95% CI 0.56-0.89). DISCUSSION: PPI use before gastric non-cardia adenocarcinoma diagnosis may not be associated with an increased risk of advanced disease at presentation or of increased mortality.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Effect of Prior Proton Pump Inhibitor Use on Gastric Cancer Survival: A Population-Based Cohort Study in the 5 Nordic Countries
- Date Crossref
- 09/06/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Karolinska University Hospital Department of Molecular Medicine and Surgery pays non établi dans la noticeÉtablissement de santé
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Karolinska Institutet pays non établi dans la noticeUniversité ou école supérieure
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Icelandic Cancer Society pays non établi dans la noticeInstitution
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Oulu University Hospital Department of Surgery pays non établi dans la noticeÉtablissement de santé
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University of Oulu pays non établi dans la noticeUniversité ou école supérieure
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University of Copenhagen Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
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Norwegian University of Science and Technology Department of Public Health and Nursing pays non établi dans la noticeUniversité ou école supérieure
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Levanger Hospital Medical Department pays non établi dans la noticeÉtablissement de santé
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King's College London pays non établi dans la noticeUniversité ou école supérieure
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The Icelandic Cancer Registry pays non établi dans la noticeInstitution
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School of Cancer and Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
Department of Molecular Medicine and Surgery — Karolinska University Hospital, Karolinska Institutet et Icelandic Cancer Society, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.