Achalasia and Risk of Esophageal Squamous Cell Carcinoma and Adenocarcinoma in a Multinational Study
Rattachement africain : se, us, dk, is, no, fi. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND & AIMS: Achalasia appears to increase the risk of esophageal squamous cell carcinoma, but existing evidence relies on small studies that did not adjust for this cancer's main risk factors (ie, smoking and alcohol overconsumption). Whether achalasia increases the risk of esophageal adenocarcinoma, whose main risk factor is gastroesophageal reflux disease (GERD), is even more uncertain. This study aimed to clarify these associations. METHODS: A population-based case-control study was conducted in 5 Nordic countries from 1987 to 2023. Esophageal cancer cases (n = 35,604) were matched to 10 times as many background population controls by age, sex, calendar year, and country (n = 355,869). Conditional logistic regression provided odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for smoking and alcohol, and additionally for GERD in a mechanistic model. All variables came from national health data registries. RESULTS: Achalasia was present in 137 cases (96 squamous cell carcinomas and 41 adenocarcinomas) and 230 controls (99 squamous cell carcinomas and 131 adenocarcinomas). Achalasia was associated with a strongly increased risk of esophageal squamous cell carcinoma (OR, 9.46; 95% CI, 7.07-12.65). A moderate association was found for esophageal adenocarcinoma (OR, 3.05; 95% CI, 2.14-4.35), which attenuated after adjustment for GERD (OR, 1.44; 95% CI, 0.99-2.09). Achalasia treated with myotomy or dilation was associated with an even stronger association with esophageal squamous cell carcinoma (OR, 16.33; 95% CI, 11.26-23.67), but not with esophageal adenocarcinoma after adjustment for GERD (OR, 1.32; 95% CI, 0.76-2.30). CONCLUSIONS: Achalasia appears strongly and independently associated with esophageal squamous cell carcinoma. The association with esophageal adenocarcinoma is less strong and seems to be largely explained by GERD.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Achalasia and Risk of Esophageal Squamous Cell Carcinoma and Adenocarcinoma in a Multinational Study
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Karolinska Institutet Department of Molecular medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
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Baylor University Medical Center Baylor Scott & White Center for Esophageal Diseases pays non établi dans la noticeÉtablissement de santé
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University of Copenhagen Department of Public Health pays non établi dans la noticeUniversité ou école supérieure
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Icelandic Cancer Society pays non établi dans la noticeInstitution
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Levanger Hospital pays non établi dans la noticeÉtablissement de santé
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Oulu University Hospital Department of Surgery pays non établi dans la noticeÉtablissement de santé
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University of Oulu pays non établi dans la noticeUniversité ou école supérieure
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The Icelandic Cancer Registry pays non établi dans la noticeInstitution
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Norges Teknisk-Naturvitenskapelige Universitet (NTNU Department of Molecular medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
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School of Cancer and Pharmacological Sciences Department of Molecular medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
Department of Molecular medicine and Surgery — Karolinska Institutet, Baylor Scott & White Center for Esophageal Diseases — Baylor University Medical Center et Department of Public Health — University of Copenhagen, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.