Data from: Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions

Le résumé fourni par la source

This dataset provides the source data for the paper titled "Synaptotagmin-1 serves as a primary Zn²⁺ sensor to mediate spontaneous neurotransmitter release under pathological conditions." Data includes electrophysiological patch-clamp recordings of miniature excitatory postsynaptic currents (mEPSCs), spontaneous EPSCs (sEPSCs), and evoked EPSCs, along with single-vesicle and ensemble lipid-mixing assays (in vitro reconstitution system) measuring fusion probability (%), cumulative probability, and lipid-mixing efficiency (FRET). The dataset also covers zinc-protein or membrane-binding assays evaluating binding affinity and membrane-binding capacity, as well as vesicle docking imaging via TIRF microscopy, which quantifies docking-related fluorescence intensity and the number of docked vesicles. Data collection and analysis were conducted collaboratively across multiple institutions. Electrophysiological patch-clamp recordings and vesicle docking imaging were performed at the Key Laboratory of Xi'an Jiaotong University, while the remaining data were collected at the relevant experimental facilities of Sichuan University.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.