Yijuan Xiang

MRI analysis of androgen insensitivity syndrome

Yijuan Xiang, Wen Peng, Rui Hu, Guanghui Yang

BACKGROUND: Androgen insensitivity syndrome (AIS) is a rare disorder of sex development, and accurate preoperative imaging assessment is crucial for clinical decision-making. This study aimed to describe the magnetic resonance imaging (MRI) features of AIS, correlate imaging findings with surgical and pathological …

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α-Synuclein bound to planar membrane orchestrates self-multimerization and vesicle association

Jiaqi Fan, Yijuan Xiang, Qianli Hu, Zeyun Zhu et autres

Alpha-Synuclein (α-Syn), a presynaptic protein implicated in Parkinson's disease (PD). While α-Syn-lipid interactions mediate both physiological synaptic vesicle (SV) regulation and pathological aggregation, the mechanistic divergence between wild-type (WT) and PD-associated mutants (A30P, E46K, A53T) in modulating membrane binding dynamics and SNARE-dependent …

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Molecular mechanism of cholesterol-dependent membrane fusion in SARS-CoV-2 entry

Wei Li, Mengdan Wu, Shirong Feng, Jiaming Su et autres

Enveloped virus invasion relies on spike glycoprotein-mediated membrane fusion. Cholesterol that serves crucial roles in modulating protein conformations and membrane properties, plays an essential role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry. However, the precise regulatory mechanism of …

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Molecular mechanism of cholesterol-dependent membrane fusion in SARS-CoV-2 entry

Wei Li, Mengdan Wu, Shirong Feng, Jiaming Su et autres

Enveloped virus invasion relies on spike glycoprotein-mediated membrane fusion. Cholesterol that serves crucial roles in modulating protein conformations and membrane properties, plays an essential role in the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) cell entry. However, the precise regulatory mechanism of …

Munc18 modulates syntaxin phase separation to promote exocytosis

Qibing Pei, Qixin Chen, Zhiqi Tian, Le Zhu et autres

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Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions

Yijuan Xiang, Lele Cui, Jingyu Yao, Xiaochu Lou et autres

In the pre-synapse, vesicle fusion is a crucial process for neurotransmitter release in the nervous system. Under physiological conditions, synaptotagmin-1 (Syt1) locks synaptic vesicles in a priming state, allowing them to undergo synchronized neurotransmitter release upon Ca2+ activation. Elevation of intracellular ions …

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Data from: Synaptotagmin-1 serves as a primary Zn2+ sensor to mediate spontaneous neurotransmitter release under pathological conditions

Yijuan Xiang, Lele Cui, Jingyu Yao, Haonan Lu et autres

This dataset provides the source data for the paper titled "Synaptotagmin-1 serves as a primary Zn²⁺ sensor to mediate spontaneous neurotransmitter release under pathological conditions." Data includes electrophysiological patch-clamp recordings of miniature excitatory postsynaptic currents (mEPSCs), spontaneous EPSCs (sEPSCs), and evoked EPSCs, …

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Synergistic regulation of fusion pore opening and dilation by SNARE and synaptotagmin-1

Kaiju Li, Kaiyu Li, Jiaqi Fan, Xing Zhang et autres

Fusion pore opening is a transient intermediate state of synaptic vesicle exocytosis, which is highly dynamic and precisely regulated by the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex and synaptotagmin-1 (Syt1). Yet, the regulatory mechanism is not fully understood. In this …

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Molecular imaging of aging-related 5-hydroxymethylcytosine in cell-free DNA at the single-copy level

Mengdan Wu, Yijuan Xiang, Linwei Tang, Wei Li et autres

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A Suitable Membrane Distance Regulated by the RBD_ACE2 Interaction is Critical for SARS‐CoV‐2 Spike‐Mediated Viral Invasion

Mengdan Wu, Wei Li, Sheng Lin, Jiaqi Fan et autres

The receptor-binding domain (RBD) of spike recognizing the receptor angiotensin-converting enzyme 2 (ACE2) initiates membrane fusion between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and cell membrane. Although the structure of the RBD_ACE2 complex has been well studied, its functional mechanism in …

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Molecular Imaging of Aging-Related 5-Hydroxymethylcytosine in Cell-Free DNA at the Single-Copy Level

Mengdan Wu, Yijuan Xiang, Linwei Tang, Wei Li et autres

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Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy

Lele Cui, Hao Li, Yufeng Xi, Qianli Hu et autres

Abstract Intracellular vesicle trafficking is the fundamental process to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. These organelles transport cargo from the donor membrane to the target membrane through the cargo containing vesicles. Vesicle trafficking pathway includes vesicle formation from …

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