Infographic: SPECTRUM: study design of the global real-world study of aflibercept 8 mg in the treatment of neovascular age-related macular degeneration and diabetic macular edema

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The authors acknowledge Anshul Tank, PharmD, an employee of Bayer, for medical writing support for the development of this infographic, in accordance with Good Publication Practice guidelines ( https://www.acpjournals.org/doi/10.7326/M22-1460 ). The authors would also like to acknowledge the principal investigators of the SPECTRUM study: Adrian Fung, Amy Cohn, Andrew Chang, Devinder Chauhan, Gerald Liew, Jennifer Arnold, Paul Mitchell, Sanjeewa Wickremasinghe, Arif Samad, Brian Ballios, Cynthia Qian, David Lederer, Donald Nixon, Keyvan Koushan, Netan Choudhry, Parnian Arjmand, Raman Tuli, Robert Gizicki, Sohel Somani, Thomas Sheidow, Varun Chaudhary, Wai Ching Lam, Lasse Jørgensen Cehofski, Michael Larsen, Michael Spangsberg, Hannele Uusitalo-Järvinen, Raimo Tuuminen, Alexandre Bourhis, Aude Couturier, Audrey Giocanti-Auregan, Benjamin Wolff, Corinne Dot, David Sayag, Eric SOUIED, Flore De Bats, Frank Becquet, Frédéric Matonti, Hassiba OubrahamMebroukine, Hessam Razavi, Isabelle Aubry-Quenet, Joël Uzzan, Laurent Berthon, Laurent Kodjikian, Laurent Velasque, Marie-Noelle Delyfer, Mathieu Lehmann, Mathilde Gallice, Mélanie Tessier, Olivia Zambrowski, Philippe Schauer, Pierre-henry Gabrielle, Salomon Cohen, Stéphanie Baillif, Thi Ha Chau Tran, Vincent Gualino, Xavier Benouaich, Alexander Daudrich, Andreas Berlin, Andreas Stahl, Astrid Sader-Moritz, Ben Mehrinfar, Christian Karl Brinkmann, Christoph Arnholdt, Clemens Lange, CostinIlie Mihaescu, Erik Beeke, Fabian Höhn, Hüsnü Berk, Ines Lanzl, Joachim Wachtlin, Kai Januschowski, Katrin Lorenz, Marc Schargus, Maria-Andreéa Gamulescu, Nikolaus Feucht, Oliver Zeitz, Philipp Müller, Ralf Schmitt, Roxana Fulga, Sabine Baumgarten, Simo Murovski, Stefan Schrader, Svenja Deuchler, Tim U. Krohne, Tobias Duncker, Tobias Peters, Ulrich Thelen, Vassiliki Romanou-Papadopoulou, Vinodh Kakkassery, Walter Sekundo, Alfonso Savastano, Daniele Tognetto, Enrico Borrelli, Federico Ricci, Flavia Chiosi, Francesco Maria Bandello, Francesco Viola, Giovanni Staurenghi, Leonardo Mastropasqua, Luca Ventre, Marco Lupidi, Maria Vadalà, Niccolò Castellino, Paolo Lanzetta, Raffaella Rosa, Aoyagi Koji, Chikako Hara, Fujimura Shigeto, Fujiwara Shintaro, Hagiwara Akira, Handa Sou, Ichikawa Reiko, Kaga Tatsushi, Kaneda Masahiro, Kawano Kenichi, Kimura Hideya, Kimura Yugo, Kishino Genichiro, Kondo Nagako, Kuribara Isao, Masahiko Sugimoto, Mishima Soichiro, Miyagi Hidetaka, Miyahara Shinsuke, Mori Toshio, Nakamura Yosuke, Nishimura Tomohisa, Okado Satoshi, Sato Hiroaki, Sentaro Kusuhara, Sugita Iichiro, Takagi Mariko, Takasu Ippei, Umeda Naoyasu, Yamane Ken, Yamazaki Kenichiro, Yuji Kato, Angela Huiskamp, Hans Vingerling, Janneke Van Lith-Verhoeven, Marianne Smeets, Sankha Amarakoon, Yara Lechanteur, Yvonne de Jong-Hesse, Marius Dalby, Tayyab Ahmad, António Campos, Carlos Marques Neves, Diogo Cabral, João Nascimento, João Pedro Marques, José Roque, Maria Picoto, Ahmed Ibrahim, Hassan Al-Dhibi, Hussein Elgendy, Maher Almalis, Marwan Abouammoh, Christopher SeungKyu Lee, Daniel Duck-Jin Hwang, Don-Il Ham, HanJoo Cho, Iksoo Byon, Kyu Hyung Park, Min Sagong, Se Joon Woo, Young-Joon Jo, Alvaro Galván Gallego, Amancia Mateos Hernández, Ana Isabel Oca Lázaro, Bárbara Delás Alós, Cristina Irigoyen Laborra, Daniel Aliseda Pérez de Madrid, Elena Rigo Oliver, Erika Vázquez Cruchaga, Estanislao Gutiérrez Sánchez, Francisco Antonio Cabrera López, Francisco Javier Ascaso Puyuelo, Gustavo Fernández-Baca Vaca, Javier Zarranz Ventura, Luis Arias Barquet, María Concepción Rodríguez Villace, María Victoria Gómez Resa, Nuria Olivier Pascual, Óscar Ruiz Moreno, Renzo Renato Portilla Blanco, Vladimir Poposki Hamamdjieva, Aseel Modher Raghib, Ingar Bergstrand, Inger Westborg, Marion Silvia Schroeder, Yazgülü Yumusak, Aude Ambresin, Chiara Eandi, Christophe Valmaggia, Daniel Barthelmes, Gábor Somfai, Justus Garweg, Katja Hatz, Marion Munk, Martin Schmid, Martin Zinkernagel, Moreno Menghini, Alaa Attawan, Ammar Safar, Amr Farid, Aniruddha Agarawal, Afsar Jafree, Aires Lobo, Archana Airody, Chandoshi Mukherjee, Clare Bailey, Emily Fletcher, Gabriella De Salvo, Hani Hasan, Ian Pearce, Louise Downey, Manju Chandran, Michael Grinton, Narendra Dhingra, Niro Narendran, Saad Younis, and Vasileios Konidaris.

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