Antitumor Activity of Activated Lymphocytes and Macrophages by Liposome-borne Tumor-specific Transplantation Antigens on Postsurgical Tumor Recurrence in Murine

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Liposome-borne tumor-specific transplantation antigens (TSTA) potentiated the antitumor activity of cytotoxic lymphocytes and macrophages (Mφ) much more efficiently than empty liposomes in murine. Mφ obtained from peritoneum and lung as well as cytotoxic T-lymphocytes (CTL) such as lymphokine-activat-ed killer (LAIC) cells and tumor infiltrating lymphocytes (TIL) showed higher inhibitory activity on metastatic tumor cell growth in lung. Among the effector lymphocytes in vivo, TIL showed desiable antitumor activity by way of intra-venous injection, while peritoneal Mφ showed high cytotoxicity by intraper-itoneal injection and intraveneously alveolar Mφ also showed high cytotoxic activity. These results suggest that the suitable administrations of liposome-borne TSTA may be useful in potentiating the tumoricidal effect of effector cells in vivo, especially TIL, CTL, and Mφ, and possibly may aid in overcoming tumor metastases.

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