Maternal-fetal isoimmunization – a risk for the development of hemolytic disease of the newborn
Rattachement africain : bg. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Hemolytic disease of the newborn is a condition caused by maternal alloimmunization against fetal red blood cell antigens. Transplacental hemorrhage, for example, can provoke an immune response in the mother. As a result, IgG-class antibodies directed against fetal erythrocyte antigens are synthesized. The hemolysis that develops in the perinatal period in the fetus is a consequence of the transplacental migration of these anti-erythrocyte antibodies into the fetal circulation. Depending on the perinatal stage in which it occurs, hemolytic disease of the newborn can lead to hemolytic anemia in the infant or hydrops fetalis with subsequent fetal death. Screening for anti-erythrocyte antibodies during pregnancy, as well as the direct Coombs antiglobulin test, are important methods for monitoring alloimmunization and ensuring timely diagnosis of hemolytic disease in the fetus and newborn. This study reflects the prevalence and trends in alloimmunization among pregnant and postpartum women over a three-year period at MHAT “St. Sofia.” The aim was to determine the frequency of alloimmunization and summarize results based on specificity and clinical factors. A retrospective analysis was performed over three years, tracking blood grouping, antibody screening, and antibody identification in pregnant women, mothers, and newborns. Standard diagnostic methods were used, including the enzyme test at 37 °C, the direct and indirect Coombs antiglobulin test, and agglutination testing. The tests were performed both prenatally and postnatally. AB0 blood group incompatibility is the most common and usually occurs in pregnant women with blood group 0, whose fetus has blood group A, B, or AB. This is due to the fact that antibodies produced by individuals with blood group 0 are typically IgG, while those produced by individuals with group A or B are more often IgM. Targeted prenatal care and prophylaxis – pre- and postnatal with anti-D immunoglobulin – have significantly reduced the risk of D-alloimmunization. However, anti-D remains one of the most frequently detected antibodies in pregnant women. To maintain proper use of anti-D prophylaxis, continuous education and awareness are needed among healthcare professionals caring for pregnant women and mothers.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Maternal-fetal isoimmunization – a risk for the development of hemolytic disease of the newborn
- Date Crossref
- 14/11/2025
- Éditeur
- Pensoft Publishers
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Medical University of Sofia pays non établi dans la noticeUniversité ou école supérieure
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Medical University Plovdiv pays non établi dans la noticeUniversité ou école supérieure
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National Institute of Emergency Medicine "Pirogov" pays non établi dans la noticeÉtablissement de santé
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Saint Sofia Medical Center pays non établi dans la noticeÉtablissement de santé
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Medical University – Plovdiv pays non établi dans la noticeUniversité ou école supérieure
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Clinic of Internal Diseases pays non établi dans la noticeÉtablissement de santé
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Bulgarian Pharmaceutical Science Society pays non établi dans la noticeInstitution
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Bulgarian Pharmaceutical Union pays non établi dans la noticeInstitution
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Department of General pays non établi dans la noticeInstitution
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Pharmacy of Hospital UMHATEM “N. I. Pirogov” pays non établi dans la noticeÉtablissement de santé
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Pharmacy of Hospital UMHATEM "N. I. Pirogov" pays non établi dans la noticeÉtablissement de santé
Medical University of Sofia, Medical University Plovdiv et National Institute of Emergency Medicine "Pirogov", avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.