Accès ouvert
2026
article
OpenAlex
Yozlem Ali Kobakova, Angelina Georgieva Kirkova-Bogdanova, Maria Stamova Vakrilova Becheva, Niya Emilova Semerdzhieva et autres
This retrospective study evaluates the etiological spectrum, antimicrobial resistance patterns, and pharmacokinetic/pharmacodynamic (PK/PD) challenges in patients with sepsis treated at the Clinic of Internal Diseases, UMBALSM “N. I. Pirogov,” Sofia. A total of 760 blood cultures collected over a 24-month period (12 …
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Accès ouvert
2026
article
OpenAlex
V. Marinov, Konstantin Ivanov Kostov, Yozlem Ali Kobakova, Angelina Georgieva Kirkova-Bogdanova et autres
Gastric leak after laparoscopic sleeve gastrectomy (SG) is a rare but life-threatening complication requiring timely diagnosis and coordinated multidisciplinary management. Therapeutic options include conservative treatment, percutaneous drainage, endoscopic interventions, and surgical revision. This case describes an early gastric leak successfully managed through …
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Accès ouvert
2026
article
OpenAlex
Maria Hristova Savcheva, Angelina Georgieva Kirkova-Bogdanova, Maria Sevdelinova Chaneva, Maria Stamova Vakrilova Becheva et autres
Transfusion medicine has undergone a long historical evolution—from early attempts at animal-to-animal transfusion through animal-to-human procedures to successful human-to-human transfusions following the discovery of blood groups. Today, it represents an independent field of medical science that supports key clinical specialties, such as …
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Accès ouvert
2026
article
OpenAlex
Mina Emilova Vapireva, Kamen Valentinov Danov, Dariya Lyubomirova Todorova, Martin Alexandrov Velichkov et autres
High-flow nasal oxygenation (HFNO) may improve the safety of low-dose procedural sedation in high-risk patients, but data in anemia are limited. This prospective single-center study included 166 anemic adults undergoing elective gastrointestinal endoscopy under low-dose propofol-based intravenous anesthesia with HFNO. The mean …
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Accès ouvert
2026
article
OpenAlex
Kamen Valentinov Danov, Dariya Lyubomirova Todorova, D. Genov, Maria Sevdelinova Chaneva et autres
Background : Alcohol-related liver cirrhosis is a leading cause of chronic liver disease worldwide. Risk and progression are dose-dependent and influenced by exposure duration and sex-specific susceptibility. Aim : To evaluate the quantity and duration of alcohol consumption in patients with alcohol-related …
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Accès ouvert
2026
article
OpenAlex
Kamen Valentinov Danov, Dariya Liubomirova Todorova, Mina Stamenova Kotchkova, Maria Sevdelinova Chaneva et autres
In patients with decompensated liver cirrhosis, the presence of acute hemorrhage is a common clinical finding. The different types of bleeding that may be observed include variceal and non-variceal gastrointestinal bleeding and systemic bleeding due to abnormalities in overall coagulation status. This …
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Accès ouvert
2026
article
OpenAlex
Kamen Valentinov Danov, Dariya Lyubomirova Todorova, Mina Stamenova Kotchkova, Maria Sevdelinova Chaneva et autres
Trimebutine, a selective antispasmodic and gastrointestinal motility modulator, was evaluated for symptom control in functional dyspepsia and overlapping functional gastrointestinal disorders. A multicenter, prospective observational study was conducted in four centers in Sofia, Bulgaria, enrolling 161 patients aged 24–75 years diagnosed according …
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Accès ouvert
2025
article
OpenAlex
Maria Hristova Savcheva, Maria Stamova Vakrilova Becheva, Yozlem Ali Kobakova, Maria Georgieva Moneva-Sakelarieva et autres
Hemolytic disease of the newborn is a condition caused by maternal alloimmunization against fetal red blood cell antigens. Transplacental hemorrhage, for example, can provoke an immune response in the mother. As a result, IgG-class antibodies directed against fetal erythrocyte antigens are synthesized. …
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Accès ouvert
2025
article
OpenAlex
Konstantin Ivanov Kostov, V. Marinov, Yozlem Ali Kobakova, Maria Georgieva Moneva-Sakelarieva et autres
Introduction: This case report analyzes the clinical symptoms, comorbidity factors, surgical approach, and postoperative outcomes of a patient with hepatic flexure cancer at UMHATEM “N. I. Pirogov” EAD. Case presentation: Clinical data for a 65-year-old woman with a colonic neoplasm, operated on …
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Accès ouvert
2025
article
OpenAlex
Petar Yordanov Atanasov, Maria Georgieva Moneva-Sakelarieva, Yozlem Ali Kobakova, Stefka Achkova Ivanova et autres
Monoclonal antibodies (mAbs) are immunoglobulins with practically absolute specificity (monospecificity) for a particular antigen (epitope). Over the past three decades, monoclonal antibodies have undergone a remarkable transformation, evolving from their use predominantly as research tools to becoming increasingly powerful therapeutic agents in …
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