Characteristics and risk factors of patients with undiagnosed COPD in China: results of a nationwide study from the ‘Happy Breathing’ Programme with mixed methods evaluation
Rattachement africain : cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: Due to the big disease burden of undiagnosed chronic obstructive pulmonary disease (COPD), we aimed to investigate the differences in the characteristics and risk factors of patients with undiagnosed COPD in China. METHODS: We used data from the 'Happy Breathing' Programme through April 2023. Current study is a cohort design. Participants were divided into high risk, undiagnosed and diagnosed COPD. Univariate logistic regression, lasso regression, decision tree, random forest and gradient boosting machine were used to screen the variables. Comparisons were conducted between undiagnosed and patients with diagnosed COPD. RESULTS: A total of 1603 high-risk, 4688 undiagnosed and 1634 patients with diagnosed COPD were identified. Patients with undiagnosed COPD had the lowest level of education, the poorest COPD-related knowledge and most biofuel users compared with high-risk populations and diagnosed patients (p<0.001). After multivariable logistic regression analysis, COPD-related knowledge score (OR=0.96, 95% CI 0.95 to 0.97), COPD Assessment Test Score (OR=1.01, 95% CI 1.00 to 1.02) and modified Medical Research Council Dyspnea Scale (OR=1.26, 95% CI 1.14 to 1.39) remained significant. Analysis of follow-up data showed that patients with undiagnosed COPD had lighter symptoms and experienced less acute exacerbations than diagnosed patients (p<0.001). DISCUSSION: Most patients with COPD remain undiagnosed until they feel dyspnoea or hospitalisation due to acute exacerbation. Undiagnosed COPD contributes significantly to the disease burden. CONCLUSION: In China, patients with undiagnosed COPD were poorly educated, consumed more biofuels, smoked more and had limited COPD-related knowledge. Patients with undiagnosed COPD are also at risk of acute exacerbation. TRIAL REGISTRATION NUMBER: NCT04318912.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Characteristics and risk factors of patients with undiagnosed COPD in China: results of a nationwide study from the ‘Happy Breathing’ Programme with mixed methods evaluation
- Date Crossref
- 01/10/2025
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Capital Medical University pays non établi dans la noticeUniversité ou école supérieure
-
China-Japan Friendship Hospital Department of Pulmonary and Critical Care Medicine pays non établi dans la noticeÉtablissement de santé
-
Peking University pays non établi dans la noticeUniversité ou école supérieure
-
Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
-
Peking Union Medical College Hospital pays non établi dans la noticeÉtablissement de santé
-
China-Japan Friendship School of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Institute of Clinical Medical Sciences Data and Project Management Unit pays non établi dans la noticeStructure de recherche
-
School of Population Medicine and Public Health pays non établi dans la noticeUniversité ou école supérieure
Capital Medical University, Department of Pulmonary and Critical Care Medicine — China-Japan Friendship Hospital et Peking University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.