Accès ouvert déclaré
2025
article
Pregnancy outcomes in women with heritable thoracic aortic disease: data from the EORP ESC registry of pregnancy and cardiac disease (ROPAC) III
Johanna A van der Zande, Julie De Backer, Guillaume Jondeau, Osama Ahmad, Marjorie Richardson, F M Comoglio, Heleen B. van der Zwaan, Christina Christersson, Karishma P. Ramlakhan, Roger Hall, Mark R. Johnson, Jolien W. Roos‐Hesselink, K Vardanyan, Arthur Melkonyan, H Lachikyan, Karapet Hakobyan, Michel Mazmanian, Hamlet Hayrapetyan, A Tavaracyan, Hermine Poghosyan, Ruben H. Hovhannisyan, S Sahakyan, S Martirosyan, Jordan L. Harris, A. Pasquet, Marielle Morissens, Tatiana Besse‐Hammer, Bernhard Dumoulin, Laurence Campens, Laurent Demulier, Michèle de Hosson, Werner Budts, Alexander Van De Bruaene, A Rampelberg, Els Troost, Leen Roggen, Pieter De Meester, Julius Chacha Mwita, Eshetu Tefera, L Kontle, Ariane Marelli, Isabelle Malhamé, Jasmine Grewal, M Janzen, Pedro A. Rubio, R Vasallo Peraza, Gleiny Vázquez Hernández, Jesús Ernesto Pérez Torga, Y Gil Jiménez, R Almaleh, Ghada Youssef, Khaled Sorour, S Abebe, Demeke Mekonnen, Chala Fekadu, Dejuma Yadeta, Sophie Dupuis‐Girod, L. Delagrange, Mary Richardson, L Ghesquiere, O Domanski, Mario Estévez, Yasmine Hamoud, Sophie Gautier, Luisa Marsili, Laurence Bal-Theoleyre, Sylvie Palazzolo, M Ladouceur, A. Moine, L Eliahou, O Milleron, Maria Tchitchinadze, Yves Dulac, Clément Karsenty, Nathalie Souletie, Fernanda Bajanca, Carsten Rickers, S Blankenberg, Christoph Sinning, Christina Magnussen, E Zengin, Goetz Mueller, R Schnabel, Yskert Von Kodolitsch, R Kozlik-Feldmann, Helmut Baumgartner, Renate Schmidt, Antje Hellige, A Rietkötter, Μichael Spartalis, Alexandra Frogoudaki, Alexandra Arvanitaki, Amalia Baroutidou, George Giannakoulas, C. Karvounis, Anne Princy Steaphen, Theranirajan Ethirajan, K Kannan, V Subramanian, A Surendran, Jeba Mercy Gnanasekaran, V Natarajalingam, S Balasubramani, Hasan Ali Farhan, Israa Fadhil Yaseen, Elisabetta Mariucci, Cristina Ciuca, F Marchi, G Benedetti, Monica Baroni, Pierluigi Festa, Alessandra Parlanti, Giosuè Scognamiglio, Flavia Fusco, B Sarubbi, M Merlo, Biancamaria D’Agata Mottolese, C Carriere, G Sinagra, Marco Bobbo, Federica Ramani, Roberto Bordese, Aldo Pagano, Nicolò Montali, Valentina Donvito, Christian Remolif, F Petey, Berto J. Bouma, Steven A. J. Chamuleau, Daniëlle Robbers‐Visser, Thelma C. Konings, H Dronkert, Dolf Segers, Roland van Kimmenade, Heleen van der Zwaan, G Tjalling Sieswerda, A Evers, T. Schaap, Khadija Bano, Humaira Yasmeen, K Amir, Niket Patel, P Akhter, Rozi Khan, Saeed Ahmed Mahar, S A Habib, Małgorzata Lelonek, P. Hoffman, Magdalena Lipczyńska, Lídia de Sousa, Vítor Ferreira, T Mano, Mafalda Selas, R Cruz Ferreira, E Shlyakhto, O. B. Irtyuga, G Sefieva, Kamil Malikov, Т. М. Первунина, U Shadrina, Abdulhalim Jamal Kinsara, Domenico Galzerano, Hani Al Sergani, Wesam Kurdi, Naji Kholaif, Olga Vriz, Ahmad Alhamshari, Abdulaziz Al-Saigh, Omer F. Ahmad, S Alzaher, Bandar Alamro, Karen Sliwa, Fareda Jakoet‐Bassier, Laura Galián-Gay, A Pijuan-Domenech, Berta Miranda, Barry Gordon, Eva Furenäs, Joanna Hlebowicz, Frida Wedlund, Edit Nagy, Erney Mattsson, M Majczuk Sennstrom, Peder Sörensson, A Lutvica, Birgitta Jönelid, T Achter, Kasiyah Junus, H Gärdesten Wall, Mattias Andréasson, Daniel Tobler, Judith Bouchardy, C Blanche, Tobias Rutz, Uğur Canpolat, Y Z Sener, N. Özer, E Ayduk Gövdeli, Z Bugra, B Umman, Pelin Karaca Özer, Derya Baykız, Derya Mutlu, Hakan Yalman, Burçak Kılıçkıran Avcı, Sibel Enar, Özlem Esen, Dina Oksen, V. V. Lazoryshynets, S Siromakha, Y Davydova, A. Yu. Limanska, I Zinovchyk, Vitalii І. Kravchenko, Borys B. Kravchuk, О. V. Kravets, Н. И. Волкова, O Mazur, O Beregovyi, B T Salih, W A R Al Mahmeed, Saleem A. Wani, Fathima Farook, Ghadeera Al Mansoori, Siddharth K. Prakash, Rana O. Afifi, D Milewicz, Alana C. Cecchi, George Wells, Darrell Sparks, William E. Wagner, Carolyn Bigelow, Laura C. Colicchia, T Jentink, Matthew Loichinger, Ritu Saxena, W. Wunderlich, C Longtin, Klopper Pj, R Gobar, Jonathan Chou, Kristin L. Campbell, Robert W. Elder, Daniel Halpern, Anaïs Hausvater, Harmony R. Reynolds, Neeraj Bhalla, Alison Small, Jason I. Feinberg, Priyanka Panday, J Awerbach, Jade Porche, Sharon Stack, Lawrence T. McGrath, Abdul Wali Khan, E Pare, Patricia Woods, Craig S. Broberg, Karen J. Gibbins, Kathleen Brookfield, Mohammed Al‐Sadawi, A Cove, Nick Mann
14Citations signalées, ce qui n’est pas une note de qualité
19Institutions déclarées
9Pays d’affiliation déclarés
Rattachement africain : nl, be, fr, sa, us, it, se, ru, gb.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
AIMS: The risk of pregnancy in women with heritable thoracic aortic disease (HTAD) is estimated to be high, but supporting data are scarce. The aim of this study is to prospectively investigate pregnancy outcomes to improve patient management and care. METHODS AND RESULTS: The Registry of Pregnancy and Cardiac disease (ROPAC) III is a prospective global registry including pregnant women with known aortic pathology between 2018 and 2023. Cardiac, obstetric and fetal outcomes, beta-blocker use, and the impact of breastfeeding were investigated. Additionally, changes in aortic diameters were assessed. In total, 176 pregnancies in 170 women (mean age 32 years, 56% primigravida) with HTAD were included: 122 with Marfan syndrome, 14 with Loeys-Dietz syndrome, 10 with ACTA2 variants, and 30 with other diagnoses. There was no maternal or neonatal mortality, while six (3.4%) fetal deaths occurred. Thirteen (7.6%) women suffered a major adverse cardiac event (MACE), including six (3.5%) aortic dissections (three during and three after pregnancy). Beta-blockers were used throughout pregnancy by 83 (47%) women. Women taking beta-blockers did not experience less MACE, aortic dissection, or aortic growth. Breastfeeding women had a significantly lower occurrence of MACE compared with non-breastfeeding women. The aortic diameter showed significant growth during pregnancy. CONCLUSION: The aortic dissection rate in this cohort of women with HTAD diagnosis prior to pregnancy, under surveillance in specialized clinics, was lower than previously reported. Our results suggest that pregnancy might have some effect on aortic growth and dissections did occur. This warrants close monitoring, also after delivery. Importantly, we found no association between breastfeeding and post-partum complications.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pregnancy outcomes in women with heritable thoracic aortic disease: data from the EORP ESC registry of pregnancy and cardiac disease (ROPAC) III
- Date Crossref
- 27/06/2025
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Cardiovascular Issues in PregnancyAortic Disease and Treatment ApproachesPregnancy and Medication Impact