Tânia Branco Mano

Lactoferrin: a new ally in mitigating anthracycline cardiotoxicity?

Tânia Branco Mano, Vera Vaz Ferreira

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Left atrial reservoir strain by speckle-tracking echocardiography predicts prognosis in secondary mitral valve insufficiency

Ricardo Micael Mendes Morais Carvalheiro, Miguel Marques Antunes, Vera Vaz Ferreira, Ana Leal et autres

BACKGROUND: Functional mitral regurgitation (FMR) contributes significantly to morbidity and mortality and may result from left ventricular (VFMR) or atrial (AFMR) remodelling. Left atrial reservoir strain (LASR) is a sensitive marker of atrial dysfunction and may offer incremental prognostic value. This study …

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Secondary mitral regurgitation subtypes: linking etiology, left atrial mechanics, and clinical phenotypes

Rubens Andreole Carvalheiro, M Marques Antunes, V Vaz Ferreira, I Cardoso et autres

Abstract Introduction Secondary mitral regurgitation (SMR) arises from diverse mechanisms impacting the mitral apparatus. Ventriculogenic SMR (SMR-V) is driven by left ventricular (LV) dysfunction or dilation, whereas atriogenic SMR (SMR-A) stems from atrial remodeling, frequently linked with atrial fibrillation (AF) or HFpEF. …

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Bridging the divide: left atrial reservoir strain as a predictor of outcomes in ventriculogenic and atriogenic mitral regurgitation

Rubens Andreole Carvalheiro, M Marques Antunes, V Vaz Ferreira, I Cardoso et autres

Abstract Background Secondary (functional) mitral regurgitation (SMR) confers increased morbidity and mortality, even in patients with relatively preserved left ventricular ejection fraction (LVEF). Left atrial reservoir strain (LASR), as measured by speckle-tracking echocardiography (STE), has emerged as a sensitive marker of LA …

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Cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome: data from the European Society of Cardiology EURObservational Research Programme Registry of Pregnancy and Cardiac Disease (ROPAC) III

Johanna A van der Zande, Jasmin Grewal, Arie Franx, Wael A. Al Mahmeed et autres

BACKGROUND AND AIMS: Data on cardiovascular outcomes and aortic growth in pregnant women with Turner syndrome is limited. We examine the cardiovascular and pregnancy outcomes in these women and analyze aortic growth throughout pregnancy. METHODS: The ROPAC III is a global, prospective, …

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Concomitant carcinoid heart disease and patent foramen ovale: a case report and review of literature

Nuno Cotrim, José Ricardo Carvalheiro, B Lacerda Teixeira, Tânia Branco Mano et autres

BACKGROUND: Carcinoid Heart Disease (CHD) primarily affects the right heart valves, while left heart involvement is rare and often associated with a patent foramen ovale (PFO). Early identification of a PFO in CHD can be critical to patient outcomes. A 61-year-old woman …

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Uprising heart failure therapies for cardio-permissive strategies in cancer therapy-related cardiac dysfunction

L. P. Magalhães, Rubens Andreole Carvalheiro, I Cardoso, V Ferreira et autres

Abstract Abstract Permissive cardiotoxicity is a novel concept in cardio-oncology that balances the need for life saving oncological therapy with the acceptance of its cardiotoxicity. One of the most feared cardiotoxicities of chemotherapy (QT) is cancer therapy-related cardiac dysfunction (CTRCD) which often …

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The delicate balance of permissive cardiotoxicity strategy in cancer-related cardiac dysfunction at a tertiary Centre: a comparative analysis

Luís Alberto de Albuquerque Magalhães, Rubens Andreole Carvalheiro, I Cardoso, V Ferreira et autres

Abstract Abstract Cancer therapy-related cardiac dysfunction (CTRCD) is a common cause of early suspension of chemotherapy (QT), potentially impacting survival rates. Permissive cardiotoxicity emphasises the continuation of cancer treatments while managing cardiotoxic effects. This study assesses clinical outcomes in patients with CTRCD …

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Cardiotoxicity in ibrutinib-treated patients: incidence, management, and impact on treatment outcomes

Rubens Andreole Carvalheiro, Luís Alberto de Albuquerque Magalhães, I Cardoso, V Ferreira et autres

Abstract Introduction Ibrutinib, a Bruton's tyrosine kinase inhibitor, has revolutionized treatment for various hematologic malignancies but is associated with cardiovascular toxicities (CTR-CVT), particularly atrial fibrillation (AF) and hypertension (HTN). Understanding the incidence, severity, and clinical impact of CTR-CVT is critical for optimizing …

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Pregnancy outcomes in women with heritable thoracic aortic disease: data from the EORP ESC registry of pregnancy and cardiac disease (ROPAC) III

Johanna A van der Zande, Julie F A De Backer, Guillaume Jondeau, Osama Ahmad et autres

AIMS: The risk of pregnancy in women with heritable thoracic aortic disease (HTAD) is estimated to be high, but supporting data are scarce. The aim of this study is to prospectively investigate pregnancy outcomes to improve patient management and care. METHODS AND …

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Valve replacement during pregnancy: literature review including new data from the Registry Of Pregnancy And Cardiac disease III

Johanna A van der Zande, С. О. Сіромаха, Ghada Youssef, Laura Galián-Gay et autres

OBJECTIVES: Heart valve replacement during pregnancy is sometimes unavoidable, and the need for anticoagulation further complicates these procedures. Our study describes cases of valve replacement in pregnancy enrolled in the Registry Of Pregnancy And Cardiac disease (ROPAC) III and gives an overview …

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Right ventricular myocardial work: proof-of-concept for the assessment of pressure-strain loops of patients with pre-capillary pulmonary hypertension

B Lacerda Teixeira, Francisco Albuquerque, Raquel Baggen Santos, André Ferreira et autres

BACKGROUND: Right ventricular myocardial work (RVMW) assessed by transthoracic echocardiography allows to study the right ventricular (RV) function using RV pressure-strain loops. The assessment of these novel indexes of RVMW has not yet been exten sively studied, namely in pre-capillary pulmonary hypertension …

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