Figure 4 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

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GLUT1 inhibition potentiates oxidative cytotoxicity of radiation in human HNSCC cell lines. A and B,In vitro proliferation (top) and intracellular H2O2 levels (bottom) of FaDu cells treated with WZB117 (20 μmol/L; A) or BAY-876 (100 nmol/L; B) with or without radiotherapy (RT, 4 Gy; n = 6 for each group). Two-way ANOVA (top) or two-tailed t test (bottom). ****, P < 0.0001; **, P < 0.01. C and D,In vitro proliferation (top) and intracellular H2O2 levels (bottom) of SCC-61 cells treated with WZB117 (20 μmol/L; C) or BAY-876 (100 nmol/L; D) with or without radiation (RT, 4 Gy; n = 6 for each group). Two-way ANOVA (top) or two-tailed t test (bottom). ****, P < 0.0001; ***, P < 0.001. E–J, Colony formation of HNSCC cells FaDu (E, F, and I) and Detroit 562 (G, H, and J) treated with WZB117 (20 μmol/L) or BAY-876 (100 nmol/L) with or without RT (4 Gy). Colonies were stained with crystal violet, and the colony area was measured using ImageJ (n = 3). Two-tailed t test. ****, P < 0.0001; ***, P < 0.001; **, P < 0.01; *, P < 0.05. BAY, BAY-876; RLU, relative light unit; WZB, WZB117.

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