Ji Yun Jeong

Engineering next-generation polyethylenimine vectors for efficient siRNA delivery in cancer

Ritu Singhmar, Ji Yun Jeong, Cheol Am Hong

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PEGylation Overcomes Pharmacological Barriers to Improve Systemic Pharmacokinetics and Therapeutic Efficacy of Phages against MDR Escherichia coli

Md Shamsuzzaman, Yoon-Jung Choi, Shukho Kim, Ji Yun Jeong et autres

Systemic bacteriophage therapy against multidrug-resistant (MDR) Escherichia coli is fundamentally limited by rapid immune-mediated clearance, complement activation, and phagocytic sequestration, collectively constituting pharmacological barriers that restrict systemic bioavailability, shorten circulation half-life, and attenuate therapeutic efficacy.We hypothesized that PEGylation, by sterically shielding phage …

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Supplementary Information from Dual Impact of IGF2 on Alveolar Stem Cell Function during Tobacco-Induced Injury Repair and Development of Pulmonary Emphysema and Cancer

Hye‐Jin Boo, Hye‐Young Min, Choon-Sik Park, Jong‐Sook Park et autres

Supplementary Methods, Tables, and Figures

National quality assurance program using digital cytopathology: a 5-year digital transformation experience by the Korean Society for Cytopathology

Yosep Chong, Hyeong Ju Kwon, Soon Auck Hong, Sung Sun Kim et autres

BACKGROUND: Digital cytopathology (DC) is emerging as a transformative approach in quality assurance programs (QAP), though its comprehensive evaluation remains limited. Since 2020, the Korean Society for Cytopathology has progressively incorporated DC into its national QAP, including digital proficiency testing (PT), sample …

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Unveiling Shared Genetic Risks of Type 2 and Post-Transplant Diabetes Mellitus in East Asians through Polygenic Risk Scores

S. Park, Heejoon Jang, Beom Joon Kim, M. Kim et autres

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Figure 4 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

GLUT1 inhibition potentiates oxidative cytotoxicity of radiation in human HNSCC cell lines. A and B,In vitro proliferation (top) and intracellular H2O2 levels (bottom) of FaDu cells treated with WZB117 (20 μmol/L; A) or BAY-876 (100 nmol/L; B) with or without radiotherapy (RT, …

Figure S3 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Supplementary Figure 3 and legend

Figure 7 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Insulin signaling promotes glucose-mediated antioxidative capacities in HNSCC. A,In vitro proliferation of FaDu cells in 25 mmol/L glucose media treated with or without 5 ng/mL insulin (n = 4 for each group). Two-way ANOVA. ****, P < 0.0001. B, Immunoblot analysis of …

Figure 6 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Auranofin induces cytotoxicity as a pro-oxidant in HNSCC. A and B,In vitro proliferation (top) and intracellular H2O2 levels (bottom) of FaDu (A) or SCC-61 (B) cells treated with vehicle, WZB117 (20 μmol/L), auranofin (1 μmol/L), or combination of WZB117 and auranofin (n …

Figure 8 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Dysregulated insulin signaling reduces HNSCC tumor growth. A, Plasma insulin concentration of vehicle- or STZ-treated mice (40 mg/kg i.p. for 5 consecutive days; n = 4 for each group). Two-tailed t test. *, P < 0.05. B, Representative H&E staining of pancreatic …

Figure 3 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

GLUT1 inhibition enhances cytotoxic oxidative stress in human HNSCC cell lines. A,In vitro proliferation and immunoblot analyses of shScramble (shScr) and shRNA-mediated KD of GLUT1 (shGLUT1) in HNSCC cell line FaDu (n = 4 for each group). Two-way ANOVA. ****, P < …

Figure S1 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Supplementary Figure 1 and Legend