Tae Hoon Kim

A Modular Design of a Cholera Toxin B Subunit‐Scaffolded Sub‐Virion Nanoparticle Vaccine Against West Nile Virus

Hyun Byun, Tae Hoon Kim, Jemin Sung, Jung‐Min Lee et autres

Although veterinary vaccines against West Nile virus (WNV) have been developed, no approved human vaccine is currently available, highlighting the need for scalable and safer WNV vaccine candidates. In this study, a recombinant WNV subunit nanoparticle vaccine was developed by displaying the …

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Cancer-associated fibroblast-derived GAS6 increases resistance to chemotherapy through AXL/STAT3/ABCG1 in gastric cancer

Tae Hoon Kim, Dagyeong Lee, Hye Jeong Oh, In‐Hye Ham et autres

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Noninvasive Detection and Thermal Ablation Therapy of Endometriosis Using Silica‐Coated Gold Nanorods

Panangattukara Prabhakaran Praveen Kumar, Seock‐Jin Chung, Kay Hadrick, Meghan Hill et autres

Endometriosis (EM) is a gynecological disease where endometrial tissue grows outside the uterus. Current diagnostic methods are mainly through surgical visualization with histological verification; there's a need for noninvasive approaches. Herein, we report photoacoustic imaging (PAI) can be a noninvasive imaging modality …

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Figure 4 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

GLUT1 inhibition potentiates oxidative cytotoxicity of radiation in human HNSCC cell lines. A and B,In vitro proliferation (top) and intracellular H2O2 levels (bottom) of FaDu cells treated with WZB117 (20 μmol/L; A) or BAY-876 (100 nmol/L; B) with or without radiotherapy (RT, …

Figure S3 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Supplementary Figure 3 and legend

Figure 7 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Insulin signaling promotes glucose-mediated antioxidative capacities in HNSCC. A,In vitro proliferation of FaDu cells in 25 mmol/L glucose media treated with or without 5 ng/mL insulin (n = 4 for each group). Two-way ANOVA. ****, P < 0.0001. B, Immunoblot analysis of …

Figure 6 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Auranofin induces cytotoxicity as a pro-oxidant in HNSCC. A and B,In vitro proliferation (top) and intracellular H2O2 levels (bottom) of FaDu (A) or SCC-61 (B) cells treated with vehicle, WZB117 (20 μmol/L), auranofin (1 μmol/L), or combination of WZB117 and auranofin (n …

Figure 8 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Dysregulated insulin signaling reduces HNSCC tumor growth. A, Plasma insulin concentration of vehicle- or STZ-treated mice (40 mg/kg i.p. for 5 consecutive days; n = 4 for each group). Two-tailed t test. *, P < 0.05. B, Representative H&E staining of pancreatic …

Figure 3 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

GLUT1 inhibition enhances cytotoxic oxidative stress in human HNSCC cell lines. A,In vitro proliferation and immunoblot analyses of shScramble (shScr) and shRNA-mediated KD of GLUT1 (shGLUT1) in HNSCC cell line FaDu (n = 4 for each group). Two-way ANOVA. ****, P < …

Figure S1 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Supplementary Figure 1 and Legend

Data from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Abstract Head and neck squamous cell carcinoma (HNSCC) remains a clinically challenging malignancy with limited targeted therapy options and poor patient outcomes. Thus, identifying unique dependencies, including HNSCC-specific metabolic reprogramming, is imperative for improving treatment strategies for this disease. In this study, …

Figure S2 from Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth

Simbarashe Mazambani, Seong-Ho Park, Joshua H. Choe, An H. Nguyen et autres

Supplementary Figure 2 and legend