Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults
Rattachement africain : jp, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
ABSTRACT The concept of genome–microbiome interactions, in which the microenvironment determined by host genetic polymorphisms regulates the local microbiota, is important in the pathogenesis of human disease. In otolaryngology, the resident bacterial microbiota is reportedly altered in non-infectious ear diseases, such as otitis media pearls and exudative otitis media. We hypothesized that a single-nucleotide polymorphism in the ATP-binding cassette sub-family C member 11 ( ABCC11 ) gene, which determines earwax properties, regulates the ear canal microbiota. We analyzed ABCC11 gene polymorphisms and ear canal microbiota in healthy individuals to understand the relationship between genome–microbiome interactions in the ear canal. The study included 21 subjects who were divided into two groups: 538GA (9) and 538AA (12). Staphylococcus auricularis and Corynebacterium spp. were observed in the 538GA group, whereas Methylocella spp. was observed in the 538AA group. PICRUSt analysis revealed significant enrichment of certain pathways, such as superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation, chlorosalicylate degradation, mycothiol biosynthesis, and enterobactin biosynthesis in the GA group, whereas allantoin degradation IV (anaerobic), nitrifier denitrification, starch degradation III, L-valine degradation I, and nicotinate degradation I were significantly enriched in the AA group. The ABCC11 gene polymorphism regulates the composition of the ear canal microbiota and its metabolic pathways. This study revealed a genome–microbiome interaction within the resident microbiota of the external auditory canal that may help to elucidate the pathogenesis of ear diseases and develop novel therapies. IMPORTANCE The ABCC11 gene polymorphism, which determines earwax characteristics, regulates the composition of the ear canal microbiota and its metabolic pathways. We determined the presence of genome–microbiome interactions in the resident microbiota of the ear canal. Future studies should focus on ABCC11 gene polymorphisms to elucidate the pathogenesis of ear diseases and develop therapeutic methods.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Association between the <i>ABCC11</i> gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults
- Date Crossref
- 04/02/2025
- Éditeur
- American Society for Microbiology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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SHOWA Medical University pays non établi dans la noticeUniversité ou école supérieure
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SHOWA Medical University Fujigaoka Hospital pays non établi dans la noticeÉtablissement de santé
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Therapeutics Clinical Research pays non établi dans la noticeStructure de recherche
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SHOWA Medical University Hospital pays non établi dans la noticeÉtablissement de santé
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Tokai University Department of Gastroenterological Surgery pays non établi dans la noticeUniversité ou école supérieure
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Nihon University Department of Orthopaedic Surgery pays non établi dans la noticeUniversité ou école supérieure
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Showa University Fujigaoka Hospital Department of Otolaryngology pays non établi dans la noticeUniversité ou école supérieure
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Showa University Graduate School of Medicine Department of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmacy Department of Hospital Pharmaceutics pays non établi dans la noticeUniversité ou école supérieure
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Showa University Graduate School of Dentistry Department of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
SHOWA Medical University, SHOWA Medical University Fujigaoka Hospital et Therapeutics Clinical Research, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.