Sumito Kumagai

Marine Biodegradable Polylactide-Based Materials

Sumito Kumagai, Motosuke Imada, Senri Hayashi, Tomohiro Hiraishi et autres

Polylactide (PLA) is a widely used biopolymer. However, it has low biodegradability in natural environments, including soil, marine, and freshwater systems. Given the severity of plastic pollution in the ocean, this study was aimed at enhancing the marine biodegradability of PLA. This …

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Processing, Structural Analysis, and Enzymatic Degradation of Poly(ethylene succinate) Melt-Spun Fibers

Taizo Kabe, Sumito Kumagai, Yasumasa Takenaka, Hideki Abe et autres

Biodegradable fibers with sufficient tensile strength for general-purpose applications were successfully fabricated from biobased poly(ethylene succinate) (PES) via a three-step process comprising intermediate annealing, heat drawing, and final annealing. Crystallization behaviors were first evaluated using isothermal half-crystallization times, which showed rapid crystallization …

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環境生分解を指向したポリエチレンサクシネートを基盤とする合成高分子材料の開発

澄人 熊谷, Sumito Kumagai

PEG-Coating as a Promotional Tool for Improving Biodegradability and Preserving Mechanical Properties of Enzyme-Embedded Polyesters

QiuYuan Huang, Satoshi Kimura, Jin Ho Seok, Sumito Kumagai et autres

Enzyme embedding, which enhances polymer degradation by embedding enzymes directly into the material matrix, has recently gained significant attention. This study explored the development of high-performance biodegradable plastics by embedding enzyme Humicola insolens cutinase (HiC) coated with polyethylene glycol (PEG) of 400–20,000 …

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Imparting Marine Biodegradability to Poly(Ethylene Succinate) (PES) by Blending with a PES-Based Copolymer

Sumito Kumagai, Motosuke Imada, Senri Hayashi, Hideki Abe et autres

In this study, a method was developed for imparting marine biodegradability to poly(ethylene succinate) (PES) by blending it with a marine biodegradable PES-based copolymer containing sebacic acid (SebA), which was denoted as PESSeb15. In a previous study, the marine biodegradability of PES-based …

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A Single-Blind, Placebo-Controlled Crossover Study of the Sedative Effects of Yokukansan in Healthy Adults Assessed by Saccadic Eye Movement Analysis

Jun Miura, Takuya MIZUGAMI, Yasunobu Amari, Sumito Kumagai et autres

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Synthesis and characterization of block copolymers consisting of poly(ethylene succinate) and poly(amino acid)s

Sumito Kumagai, Motosuke Imada, Senri Hayashi, Atsushi Katsuragi et autres

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Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults

Yasunobu Amari, Masahiro Hosonuma, Takuya Mizukami, Junya Isobe et autres

ABSTRACT The concept of genome–microbiome interactions, in which the microenvironment determined by host genetic polymorphisms regulates the local microbiota, is important in the pathogenesis of human disease. In otolaryngology, the resident bacterial microbiota is reportedly altered in non-infectious ear diseases, such as …

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One-Pot Synthesis of Marine-Biodegradable Poly(Ethylene Succinate)-Based Ester Amide Copolymers Containing Amino Acid

Sumito Kumagai, Senri Hayashi, Atsushi Katsuragi, Motosuke Imada et autres

High Resolution Image Download MS PowerPoint Slide We developed a cost-effective one-pot method for synthesizing marine-biodegradable poly(ethylene succinate) (PES)-based ester amide copolymers containing natural amino acids, while suppressing the formation of N -succinimide rings. In conventional batch copolymerization, N -succinimide rings are …

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Improving the marine biodegradability of poly(alkylene succinate)-based copolymers

Sumito Kumagai, Senri Hayashi, Atsushi Katsuragi, Motosuke Imada et autres

Abstract We report the syntheses of novel marine biodegradable poly(ethylene succinate) (PES)- and poly(butylene succinate) (PBS)-based copolymers containing different dicarboxylic acid (DCA) units with various carbon numbers and different feed ratios. Biochemical oxygen demand tests demonstrated that some of the obtained PES- …

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Synthesis and Characterization of Block Copolymers Consisting of Poly(Ethylene Succinate) and Poly(Amino Acid)S

Yasumasa Takenaka, Sumito Kumagai, Motosuke Imada, Senri Hayashi et autres

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Decreased cardiac mitochondrial tetrahydrobiopterin in a rat model of pressure overload

Shunichi Shimizu, Masaaki Ishibashi, Sumito Kumagai, Teruaki Wajima et autres

Sustained cardiac pressure overload induces mitochondrial dysfunction and apoptosis of cardiomyocytes leading to pathological cardiac hypertrophy and dysfunction. Mitochondrial nitric oxide synthase (NOS) appears to cause uncoupling, which produces reactive oxygen species (ROS) instead of nitric oxide (NO), by a decrease in …

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