Accès ouvert déclaré 2024 article

7430 Impact Of Environmental Pollution On Adrenocortical Carcinoma In Italy

Soraya Puglisi, Anna Calabrese, Francesco Ferraù, Ylenia Alessi, Marta Laganà, Salvatore Grisanti, Filippo Ceccato, Carla Maria Scaroni, Guido Di Dalmazi, Antonio Stigliano, Barbara Altieri, Letizia Canu, Michaela Luconi, Paola Loli, Maria De Martino, Emanuela Arvat, Serena Palmieri, Paola Perotti, Valentina Basile, Paola Berchialla, Sara Urru, Alfredo Berruti, A. Pia, Giuseppe Reimondo, Salvatore Cannavò, Massimo Terzolo

1Citations signalées, ce qui n’est pas une note de qualité

14Institutions déclarées

4Pays d’affiliation déclarés

Rattachement africain : it, us, jp, in. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Abstract Disclosure: S. Puglisi: None. A. Calabrese: None. F. Ferraù: None. Y. Alessi: None. M. Laganà: None. S. Grisanti: None. F. Ceccato: None. C. Scaroni: None. G. Di Dalmazi: None. A. Stigliano: None. B. Altieri: None. L. Canu: None. M. Luconi: None. P. Loli: None. M. De Martino: None. E. Arvat: None. S. Palmieri: None. P. Perotti: None. V. Basile: None. P. Berchialla: None. S. Urru: None. A. Berruti: None. A. Pia: None. G. Reimondo: None. S. Cannavò: None. M. Terzolo: None. Background: Whether environmental pollution may influence adrenocortical carcinoma (ACC) development remains largely unknown. The aim of this study was to evaluate the impact of exposition to environmental pollutants on ACC presentation and prognosis in Italy. Patients and Methods: A retrospective analysis was done on 500 patients affected by ACC, who were diagnosed in 12 reference centers in Italy from 1990 to 2018 and followed-up for a median of 37.5 months (interquartile range, IQR, 11-83). Patients were stratified according to: i) residence in Sites of National Interest (SIN) which are areas with contaminated soil and water, classified as dangerous by the Italian Ministry of Environment and in need of remediation; ii) residence in areas with different degrees of urbanisation, considered as index of exposure to air pollution. Results: At diagnosis, 50 (10%) patients were resident in SIN (Res-SIN) and 450 (90%) patients were not (Not-SIN). The two groups had similar characteristics in terms of age, ENSAT stage, tumor size, Weiss score and Ki67%. However, incidental diagnosis of ACC was more frequent in Not-SIN patients than in Res-SIN patients (40.0% vs 19.6%; p=0.011). Res-SIN patients showed shorter recurrence-free survival (RFS) than Not-SIN patients (21 months vs 41 months; p=0.027). In multivariate analysis, residence in SIN was an independent negative prognostic factor for RFS (HR 1.82, 95%CI 1.10-3.03; p=0.021). Overall survival (OS) showed a similar pattern although the difference between the 2 groups was not significantly different. At diagnosis, 205 (41%) patients were resident in “cities” (> 50% of population in urban centers, with density >1,500 inhabitants/km2 and population >50,000), 230 (46%) in “towns” and “suburbs” (>50% in urban clusters with density >300 inhabitants/km2 and population >5,000), and 65 (13%) in “rural areas” (> 50% of population not meeting the previous criteria). No statistically significant differences were observed among the three groups in terms of clinical presentation, RFS and OS. Conclusions: The different clinical presentation and worse outcome of ACC in patients living in areas with contaminated soil and water suggest that environmental pollutants in these matrices may have a role in conditioning the behavior of this rare tumor. Conversely, air pollution does not seem to influence the ACC disease course. Presentation: 6/2/2024

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: 7430 Impact Of Environmental Pollution On Adrenocortical Carcinoma In Italy
Date Crossref: 01/10/2024
Éditeur: The Endocrine Society
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

University of Turin Department of Clinical and Biological Sciences pays non établi dans la notice
Université ou école supérieure
University of Messina pays non établi dans la notice
Université ou école supérieure
Brescia University pays non établi dans la notice
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University of Brescia Oncology Unit pays non établi dans la notice
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University of Padua Unit of Biostatistics pays non établi dans la notice
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University of Bologna pays non établi dans la notice
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Sapienza University of Rome pays non établi dans la notice
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Università Cattolica del Sacro Cuore pays non établi dans la notice
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University of the Sacred Heart pays non établi dans la notice
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University of Florence Department of Experimental and Clinical Biomedical Sciences pays non établi dans la notice
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Ospedale San Carlo pays non établi dans la notice
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University of Naples Federico II Department of Clinical Medicine and Surgery pays non établi dans la notice
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Department of Clinical and Biological Sciences — University of Turin, University of Messina et Brescia University, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Adrenal and Paraganglionic Tumors

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