Paola Perotti

Targeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate

Aurora Schiavon, Carlotta Evaristo, Laura Saba, Jessica Petiti et autres

BACKGROUND: Adrenocortical carcinoma (ACC) is a rare, aggressive malignancy with limited treatment options. Mitotane, the only approved drug, has modest efficacy and frequent adverse effects, underscoring the urgent need for new therapeutic approaches. Celastrol, a triterpene compound derived from traditional Chinese medicine, …

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7430 Impact Of Environmental Pollution On Adrenocortical Carcinoma In Italy

Soraya Puglisi, Anna Calabrese, Francesco Ferraù, Ylenia Alessi et autres

Abstract Disclosure: S. Puglisi: None. A. Calabrese: None. F. Ferraù: None. Y. Alessi: None. M. Laganà: None. S. Grisanti: None. F. Ceccato: None. C. Scaroni: None. G. Di Dalmazi: None. A. Stigliano: None. B. Altieri: None. L. Canu: None. M. Luconi: None. …

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Management of Endocrine Syndromes Associated with Adrenocortical Carcinoma

Chiara Borin, Soraya Puglisi, Anna Calabrese, Paola Perotti et autres

Adrenocortical carcinoma (ACC) is a malignant tumor that is associated with steroid hypersecretion in up to 60% of cases. The most common hypersecretion is cortisol, followed by androgens, while aldosterone and estrogens are less frequently secreted. It is key to identify hormonal …

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Serendipitous Adrenal Hyperplasia in Patients Admitted to the Emergency Department for Suspected SARS-CoV-2 Infection is Linked to Increased Mortality

Giuseppe Reimondo, Federica Solitro, Soraya Puglisi, Maurizio Balbi et autres

BACKGROUND: Few data are available on adrenal morphology in patients with acute diseases, although it is known that endogenous glucocorticoids are essential for survival under stress conditions and that an adequate response is driven by activation of the hypothalamic-pituitary-adrenal (HPA) axis. AIMS: …

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Impact of environmental pollution on adrenocortical carcinoma in Italy

Soraya Puglisi, Anna Calabrese, Francesco Ferraù, Ylenia Alessi et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Germline NGS targeted analysis in adult patients with sporadic adrenocortical carcinoma

Maria Scatolini, Salvatore Grisanti, Pasquale Tomaiuolo, Enrico Grosso et autres

BACKGROUND: Adrenocortical carcinoma (ACC) is a rare cancer that arises sporadically or due to hereditary syndromes. Data on germline variants (GVs) in sporadic ACC are limited. Our aim was to characterize GVs of genes potentially related to adrenal diseases in 150 adult …

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THU616 Analysis Of Germline Mutations In Patients With Sporadic Adrenocortical Carcinoma

Massimo Terzolo, Salvatore Grisanti, Maria Scatolini, Pasquale Tomaiuolo et autres

Abstract Disclosure: M. Terzolo: None. S. Grisanti: None. M. Scatolini: None. P. Tomaiuolo: None. E. Grosso: None. V. Basile: None. D. Cosentini: None. S. Puglisi: None. M. Laganà: None. P. Perotti: None. L. Saba: None. E. Rossini: None. S. Sigala: None. M. …

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Adjuvant mitotane versus surveillance in low-grade, localised adrenocortical carcinoma (ADIUVO): an international, multicentre, open-label, randomised, phase 3 trial and observational study

Massimo Terzolo, Martin Faßnacht, Paola Perotti, Rossella Libé et autres

BACKGROUND: Adjuvant treatment with mitotane is commonly used after resection of adrenocortical carcinoma; however, treatment remains controversial, particularly if risk of recurrence is not high. We aimed to assess the efficacy and safety of adjuvant mitotane compared with surveillance alone following complete …

it, de, fr, hr, ca, gb, nl, us, br, ch (code pays fourni par la source)

Analysis of germline mutations in patients with non-syndromic adrenocortical carcinoma

Massimo Terzolo, Salvatore Grisanti, Maria Scatolini, Pasquale Tomaiuolo et autres

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

New Findings on Presentation and Outcome of Patients With Adrenocortical Cancer: Results From a National Cohort Study

Soraya Puglisi, Anna Calabrese, Francesco Ferraù, Maria Antonia Violi et autres

CONTEXT: Because of the rarity of adrenocortical cancer (ACC), only a few population-based studies are available, and they reported limited details in the characterization of patients and their treatment. OBJECTIVE: To describe in a nationwide cohort the presentation of patients with ACC, …

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The management of postoperative disease recurrence in patients with adrenocortical carcinoma: a retrospective study in 106 patients

Anna Calabrese, Soraya Puglisi, Chiara Borin, Vittoria Basile et autres

OBJECTIVE: The management of adrenocortical carcinoma (ACC) recurrences remains controversial, and we present herein our experience with postoperative ACC recurrences. DESIGN AND METHODS: Retrospective analysis in a single reference center of 106 patients with ACC recurrence. RESULTS: The median follow-up was 45 …

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OR12-1 Activity of Abiraterone Acetate in the management of Cushing syndrome associated to advanced adrenocortical carcinoma: results of the ABACUS trial.

Andrea Abate, Vittoria Basile, Alfredo Berruti, Anna Calabrese et autres

Abstract Background More than 50% of adrenocortical carcinomas (ACC) in adults are associated with cortisol excess that makes tumor management challenging and has a negative impact on patient outcome. Abiraterone acetate (AA) is an irreversible inhibitor of the 17α-hydroxylase/C17, 20-lyase (CYP17 enzyme) …