Filippo Ceccato

Detection of GLAS in BMAD patients with ARMC5 pathogenic variants

Filippo Ceccato, Filippo Crimì

Background: Bilateral macronodular adrenal disease (BMAD) is a rare disorder characterized by bilateral benign macronodules and variable degrees of hypercortisolism. Pathogenic variants in ARMC5 and KDM1A represent the best-established genetic etiologies. However, it remains uncertain whether quantitative/qualitative CT evaluation characterizes genetically mutated …

Clinical and pharmacological determinants of serum dexamethasone concentrations during dexamethasone suppression test

Irene Tizianel, Giorgia Antonelli, Alessandro Mondin, Andrea Cignarella et autres

CONTEXT: The 1-mg overnight dexamethasone suppression test (1-mg DST) is widely used to screen for hypercortisolism, but its interpretation may be affected by variability in dexamethasone exposure due to clinical and pharmacological factors. OBJECTIVE: To evaluate determinants of serum dexamethasone levels during …

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Clinical and pharmacological determinants of serum dexamethasone concentrations during 1-mg DST

Filippo Ceccato

Context: The 1-mg overnight dexamethasone suppression test (1-mg DST) is widely used to screen for hypercortisolism, but its interpretation may be affected by variability in dexamethasone exposure due to clinical and pharmacological factors. Objective: To evaluate determinants of serum dexamethasone levels during …

Functional hyperprolactinemia and subclinical primary hypothyroidism: myth or reality in clinical practice?

Giulia Bovo, Pierluigi Mazzeo, Giorgia Antonelli, Mattia Barbot et autres

BACKGROUND: Hyperprolactinemia is a frequent clinical condition with different etiologies. Although primary hypothyroidism is often considered a leading cause of mild hyperprolactinemia, the supporting evidence is limited and often based on small studies with single prolactin (PRL) measurement, especially in cases of …

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Fragilità ossea nella Sindrome di Cushing: meccanismi fisiopatologici e strategie terapeutiche

Giacomo Voltan, Carlo Mogno, Filippo Ceccato, Valentina Camozzi

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P56 - ECE_2749 - Modified-release hydrocortisone impact on metabolism and hormonal control in patients with congenital adrenal hyperplasia: an observational cohort study

Pierluigi Mazzeo, Irene Tizianel, Giulia Bovo, Chiara Sabbadin et autres

Abstract Background Congenital adrenal hyperplasia (CAH) is a genetic disorder characterized by impaired cortisol secretion and androgen excess. The mainstay of CAH treatment is glucocorticoid (GC) replacement, necessary to avoid adrenal crises and manage androgen excess. The delicate balance between GC under- …

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RC9.4 - ECE_1118 - Clinical and pharmacological determinants of serum dexamethasone concentrations during the dexamethasone suppression test

Irene Tizianel, Elena Pagin, Pierluigi Mazzeo, Giulia Bovo et autres

Abstract Background The dexamethasone suppression test (DST) is recommended by the European Society of Endocrinology for the evaluation of endogenous hypercortisolism, including Cushing's syndrome (CS) and autonomous cortisol secretion (MACS) in adrenal incidentalomas. A 1 mg DST is considered normal when post-test …

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EP1094 - ECE_3951 - Clinical course of non-functioning pituitary adenomas: insights from a retrospective single-center study

Alessandro Bavaresco, Filippo Ceccato, Pierluigi Mazzeo, Alberto Madinelli et autres

Abstract Background Non-functioning pituitary adenomas (NFPAs) represent the most common subtype of pituitary macroadenomas and common finding among microadenomas. NFPAs show in a wide range of clinical behaviours, from clinically silent to compressive symptoms or hypopituitarism. Despite advances in surgery and radiotherapy …

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P280 - ECE_1603 - Ketoconazole ESTEVE in endogenous Cushing’s syndrome: post-authorisation safety study in 132 patients

Anna Aulinas, Alicia Santos Vives, Frédéric Castinetti, Filippo Ceccato et autres

Abstract Background Ketoconazole ESTEVE is approved for the treatment of endogenous Cushing’s syndrome (CS) with a requirement to collect safety data in this indication. Methods The primary objective of this prospective open-label Post-Authorisation Safety Study (PASS), using the European Registry on Cushing's …

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P452 - LBA_ECE_1067 - Targeted metabolomics to distinguish primary from endocrine hypertension: results from the prospective ENSAT-HT study

Parminder Reel, Smarti Reel, Laurence Amar, Benjamin Pariente et autres

Abstract Background Arterial hypertension can be considered a global epidemic, and despite increased disease awareness and the availability of effective treatment options, global control rates remain unsatisfactory. Early identification of endocrine hypertension (EHT), including primary aldosteronism (PA), pheochromocytoma/paraganglioma (PPGL), and Cushing syndrome …

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EP1086 - ECE_1685 - The possible role of black blood magnetic resonance imaging sequences in pituitary tumor diagnosis

Pierluigi Mazzeo, Giacomo Voltan, Giulia Bovo, Filippo Ceccato et autres

Abstract Background In the diagnosis of pituitary tumors, especially in Cushing's disease (CD), conventional MRI could be inconclusive, forcing clinicians to perform invasive tests like Inferior Petrosal-Sinus Sampling (IPSS) and exploring surgery. The black-blood (BB) MRI sequences are widely used in the …

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P289 - ECE_1810 - Differential skeletal recovery after surgical vs medical remission in Cushing’s disease: a 5-year observational study

Giacomo Voltan, Pierluigi Mazzeo, Irene Tizianel, Carlo Mogno et autres

Abstract Background Skeletal fragility is a major and often irreversible complication of Cushing’s disease (CD). Although remission of hypercortisolism may allow partial bone recovery, long-term data comparing surgical and medical remission are scarce. In particular, whether sustained eucortisolism achieved through medical therapy …

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