Garry P. Duffy

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle et autres

ABSTRACT Cell therapies are a transformative pillar in healthcare, offering treatments for a diverse range of rare and chronic diseases. However, their complex supply chain relies on cryopreservation and cold‐chain logistics, which limits access to these life‐saving treatments, and the freeze–thaw process …

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A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer

Alyce Sheedy, Mihir Shetty, Anna Weis, Laura E. Bendzick et autres

Intraperitoneal (i.p.) therapy improves outcomes in abdominal cancers but remains underutilized due to complications from repurposed catheters. In this work, we present a replenishable therapeutic implant for repeated, localized delivery of therapies to the peritoneal cavity. In an ovarian cancer mouse model, …

Multimodal characterization of sustained bioagent release from an epicardial depot for long-term biomaterial incorporation

Claudia Elena Varela, David S. Monahan, Yiling Fan, Shahrin Islam et autres

Engineering hypoimmune stem cell-derived beta cells

Benedikt J. M. Licht, Garry P. Duffy, Ruth E. Levey

In type 1 diabetes (T1D), autoimmune targeting destroys insulin-producing β cells in the pancreas, creating a chronic state of insulin deficiency. Islet transplantation presents a regenerative cell therapy approach that can re-establish insulin production and intrinsic glycemic control. However, islet transplantation is …

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A CLOSED-LOOP ANTIHYPERTENSIVE DRUG-DELIVERY SYSTEM FOR MANAGEMENT OF HYPERTENSION AND BLOOD PRESSURE VARIABILITY

James M. G. Curneen, Joanne O’Dwyer, Delyth Graham, Conor S. Judge et autres

Objective: Hypertension remains the leading cause of cardiovascular (CV) morbidity and mortality worldwide. Despite current treatments, blood pressure (BP) control is often suboptimal, with BP variability (BPV) emerging as a significant risk factor for CV events. Novel wearable BP measurement technologies highlight …

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Evaluation of adipose-derived stromal cell infused modified-hyaluronic acid scaffolds for post cancer breast reconstruction

Ritihaas Surya Challapalli, Joanne O’Dwyer, Niall McInerney, Michael J. Kerin et autres

ABSTRACT Introduction Primary breast cancer surgery can compromise aesthetics and quality-of-life for breast cancer patients. While breast reconstruction improves these outcomes, current methods are limited by suboptimal aesthetic outcomes and potential complication risks. There is an urgent clinical need for improved approaches …

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Hyaluronic acid hydrogels: Establishing a sustained delivery system for extracellular vesicles

Yashna Chabria, Joanne O’Dwyer, Emma A. McDermott, Peter Owens et autres

Abstract Extracellular vesicles (EVs) are versatile transporters of genetic cargo with enormous potential in the therapeutic setting. Scalable production of EVs, and routes to overcome rapid clearance are required. Biocompatible hydrogels may support precise, localized delivery of EVs to target sites. This …

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A preliminary ex vivo diffusion tensor imaging study of distinct aortic morphologies

Brooke Tornifoglio, Scott D. Robinson, Ruth E. Levey, Alan J. Stone et autres

Changes in the microstructure of the aortic wall precede the progression of various aortic pathologies, including aneurysms and dissection. Current clinical decisions with regards to surgical planning and/or radiological intervention are guided by geometric features, such as aortic diameter, since clinical imaging …

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Improving glioblastoma treatment with imaging, radiotherapy, drug delivery, and therapeutic systems

Katarzyna Mnich, Stéphanie Lhomond, Eimear J. Wallace, Pierre‐Jean Le Reste et autres

Summary Treatments for glioblastoma face challenges related to poor prognosis and limited treatment options. Despite decades of research, the current standard of care, the Stupp protocol, only slightly prolongs the lifespan. This review discusses the potential of emerging medical devices for treating …

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Engineering a HAMAPEG Acid-Based Hamapeg Bioink for 3D Bioprinting of Pseudoislets and its in Vitro Assessment

Tapas Mitra, Abhik Mallick, Victoria Ward, Meadhbh Brennan et autres

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Actuation‐Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins

Eimear J. Wallace, Joanne O’Dwyer, Eimear B. Dolan, Liam P. Burke et autres

Therapeutic proteins, the fastest growing class of pharmaceuticals, are subject to rapid proteolytic degradation in vivo, rendering them inactive. Sophisticated drug delivery systems that maintain protein stability, prolong therapeutic effects, and reduce administration frequency are urgently required. Herein, a mechanoresponsive hydrogel is …

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ECM Proteins Nidogen‐1 and Decorin Restore Functionality of Human Islets of Langerhans upon Hypoxic Conditions

Abiramy Jeyagaran, Max Urbanczyk, Daniel Carvajal Berrio, Teresa Baldissera et autres

Transplantation of donor islets of Langerhans is a potential therapeutic approach for patients with diabetes mellitus; however, its success is limited by islet death and dysfunction during the initial hypoxic conditions at the transplantation site. This highlights the need to support the …

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