Gut Microbiota and Autism Spectrum Disorder: A Neuroinflammatory Mediated Mechanism of Pathogenesis?
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Le résumé fourni par la source
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and behavior, frequently accompanied by restricted and repetitive patterns of interests or activities. The gut microbiota has been implicated in the etiology of ASD due to its impact on the bidirectional communication pathway known as the gut-brain axis. However, the precise involvement of the gut microbiota in the causation of ASD is unclear. This study critically examines recent evidence to rationalize a probable mechanism in which gut microbiota symbiosis can induce neuroinflammation through intermediator cytokines and metabolites. To develop ASD, loss of the integrity of the intestinal barrier, activation of microglia, and dysregulation of neurotransmitters are caused by neural inflammatory factors. It has emphasized the potential role of neuroinflammatory intermediates linked to gut microbiota alterations in individuals with ASD. Specifically, cytokines like brain-derived neurotrophic factor, calprotectin, eotaxin, and some metabolites and microRNAs have been considered etiological biomarkers. We have also overviewed how probiotic trials may be used as a therapeutic strategy in ASD to reestablish a healthy balance in the gut microbiota. Evidence indicates neuroinflammation induced by dysregulated gut microbiota in ASD, yet there is little clarity based on analysis of the circulating immune profile. It deems the repair of microbiota load would lower inflammatory chaos in the GI tract, correct neuroinflammatory mediators, and modulate the neurotransmitters to attenuate autism. The interaction between the gut and the brain, along with alterations in microbiota and neuroinflammatory biomarkers, serves as a foundational background for understanding the etiology, diagnosis, prognosis, and treatment of autism spectrum disorder.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Gut Microbiota and Autism Spectrum Disorder: A Neuroinflammatory Mediated Mechanism of Pathogenesis?
- Date Crossref
- 02/08/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shahrekord University of Medical Sciences Students Research Committee pays non établi dans la noticeUniversité ou école supérieure
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Shahid Beheshti University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Aja University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Islamic Azad University Medical Branch of Tehran Tehran Medical Sciences Branch pays non établi dans la noticeUniversité ou école supérieure
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Isfahan University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Northwestern University pays non établi dans la noticeUniversité ou école supérieure
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Renal Research Institute pays non établi dans la noticeStructure de recherche
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Institute of Physical Chemistry pays non établi dans la noticeStructure de recherche
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Polish Academy of Sciences pays non établi dans la noticeOrganisme public
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Faculty of Allied Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Aerospace and Subaquatic Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Student Research Committee pays non établi dans la noticeUniversité ou école supérieure
Students Research Committee — Shahrekord University of Medical Sciences, Shahid Beheshti University of Medical Sciences et Aja University of Medical Sciences, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.