Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible GABAergic transmission intervention
Rattachement africain : bd, sa, it, Égypte, jo. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Quercetin is the most common polyphenolic flavonoid present in fruits and vegetables demonstrating versatile health‐promoting effects. This study aimed to examine the effects of quercetin (QR) and sclareol (SCL) on the thiopental sodium (TS)‐induced sleeping and forced swimming test (FST) mouse models. SCL (1, 5, and 10 mg/kg, p.o.) or QR (50 mg/kg, p.o.) and/or diazepam (DZP) (3 mg/kg, i.p.) were employed. After 30 min of TS induction, individual or combined effects on the animals were checked. In the FST test, the animals were subjected to forced swimming after 30 min of administration of the test and/or controls for 5 min. In this case, immobility time was measured. In silico studies were conducted to evaluate the involvement of GABA receptors. SCL (5 and 10 mg/kg) significantly increased the latency and decreased sleeping time compared to the control in the TS‐induced sleeping time study. DZP (3 mg/kg) showed a sedative‐like effect in animals in both sleeping and FST studies. QR (50 mg/kg) exhibited a similar pattern of activity as SCL. However, its effects were more prominent than those of SCL groups. SCL (10 mg/kg) altered the DZP‐3‐mediated effects. SCL‐10 co‐treated with QR‐50 significantly (p < 0.05) increased the latency and decreased sleep time and immobility time, suggesting possible synergistic antidepressant‐like effects. In silico studies revealed that SCL and QR demonstrated better binding affinities with GABAA receptor, especially α2, α3, and α5 subunits. Both compounds also exhibited good ADMET and drug‐like properties. In animal studies, the both compounds worked synergistically to provide antidepressant‐like effects in a slightly different fashion. As a conclusion, the combined administration of SCL and QR may be used in upcoming neurological clinical trials, according to in vivo and in silico findings. However, additional investigation is necessary to verify this behavior and clarify the potential mechanism of action.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Quercetin increases the antidepressant‐like effects of sclareol and antagonizes diazepam in thiopental sodium‐induced sleeping mice: A possible <scp>GABAergic</scp> transmission intervention
- Date Crossref
- 27/02/2024
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Gopalganj Science and Technology University pays non établi dans la noticeUniversité ou école supérieure
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King Saud University Department of Pharmaceutical Chemistry pays non établi dans la noticeUniversité ou école supérieure
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University of Turin Department of Drug Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Ain Shams University Department of Pharmacognosy Cairo, Égypte (code pays fourni par la source)Université ou école supérieure
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University of Jordan Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalganj Bangladesh Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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College of Pharmacy Department of Pharmaceutical Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Pharmacognosy Cairo, Égypte (pays nommé en fin d’affiliation)Université ou école supérieure
Gopalganj Science and Technology University, Department of Pharmaceutical Chemistry — King Saud University et Department of Drug Science and Technology — University of Turin, avec 5 autres affiliations. Pays d’affiliation : Égypte.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.