Quercetin Antagonizes the Sedative Effects of Linalool, Possibly through the GABAergic Interaction Pathway
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Le résumé fourni par la source
Sedatives promote calmness or sleepiness during surgery or severely stressful events. In addition, depression is a mental health issue that negatively affects emotional well-being. A group of drugs called anti-depressants is used to treat major depressive illnesses. The aim of the present work was to evaluate the effects of quercetin (QUR) and linalool (LIN) on thiopental sodium (TS)-induced sleeping mice and to investigate the combined effects of these compounds using a conventional co-treatment strategy and in silico studies. For this, the TS-induced sleeping mice were monitored to compare the occurrence, latency, and duration of the sleep-in response to QUR (10, 25, 50 mg/kg), LIN (10, 25, 50 mg/kg), and diazepam (DZP, 3 mg/kg, i.p.). Moreover, an in silico investigation was undertaken to assess this study’s putative modulatory sedation mechanism. For this, we observed the ability of test and standard medications to interact with various gamma-aminobutyric acid A receptor (GABAA) subunits. Results revealed that QUR and LIN cause dose-dependent antidepressant-like and sedative-like effects in animals, respectively. In addition, QUR-50 mg/kg and LIN-50 mg/kg and/or DZP-3 mg/kg combined were associated with an increased latency period and reduced sleeping times in animals. Results of the in silico studies demonstrated that QUR has better binding interaction with GABAA α3, β1, and γ2 subunits when compared with DZP, whereas LIN showed moderate affinity with the GABAA receptor. Taken together, the sleep duration of LIN and DZP is opposed by QUR in TS-induced sleeping mice, suggesting that QUR may be responsible for providing sedation-antagonizing effects through the GABAergic interaction pathway.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Quercetin Antagonizes the Sedative Effects of Linalool, Possibly through the GABAergic Interaction Pathway
- Date Crossref
- 24/07/2023
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Gopalganj Science and Technology University pays non établi dans la noticeUniversité ou école supérieure
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King Khalid University pays non établi dans la noticeUniversité ou école supérieure
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RMIT University pays non établi dans la noticeUniversité ou école supérieure
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University of Jordan Department of Chemistry pays non établi dans la noticeUniversité ou école supérieure
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Bangabandhu Sheikh Mujibur Rahman Science and Technology University Department of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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College of Applied Medical Sciences Department of Clinical Laboratory Sciences pays non établi dans la noticeUniversité ou école supérieure
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Gopalganj Science and Technology University, King Khalid University et RMIT University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.