Intensive neurorehabilitation and allogeneic stem cells transplantation in canine degenerative myelopathy
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Le résumé fourni par la source
Introduction Degenerative myelopathy (DM) is a neurodegenerative spinal cord disease with upper motor neurons, with progressive and chronic clinical signs, similar to amyotrophic lateral sclerosis (ALS). DM has a complex etiology mainly associated with SOD1 gene mutation and its toxic role, with no specific treatment. Daily intensive rehabilitation showed survival time near 8 months but most animals are euthanized 6–12 months after clinical signs onset. Methods This prospective controlled blinded cohort clinical study aims to evaluate the neural regeneration response ability of DM dogs subjected to an intensive neurorehabilitation protocol with mesenchymal stem cells (MSCs) transplantation. In total, 13 non-ambulatory (OFS 6 or 8) dogs with homozygous genotype DM/DM and diagnosed by exclusion were included. All were allocated to the intensive neurorehabilitation with MSCs protocol (INSCP) group (n = 8) or to the ambulatory rehabilitation protocol (ARP) group (n = 5), which differ in regard to training intensity, modalities frequency, and MSCs transplantation. The INSCP group was hospitalized for 1 month (T0 to T1), followed by MSCs transplantation (T1) and a second month (T2), whereas the ARP group was under ambulatory treatment for the same 2 months. Results Survival mean time of total population was 375 days, with 438 days for the INSCP group and 274 for the ARP group, with a marked difference on the Kaplan–Meier survival analysis. When comparing the literature's results, there was also a clear difference in the one-sample t-test (p = 0.013) with an increase in time of approximately 70%. OFS classifications between groups at each time point were significantly different (p = 0.008) by the one-way ANOVA and the independent sample t-test. Discussion This INSCP showed to be safe, feasible, and a possibility for a long progression of DM dogs with quality of life and functional improvement. This study should be continued.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Intensive neurorehabilitation and allogeneic stem cells transplantation in canine degenerative myelopathy
- Date Crossref
- 13/07/2023
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Lusófona pays non établi dans la noticeUniversité ou école supérieure
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University of Lisbon pays non établi dans la noticeUniversité ou école supérieure
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Universidade do Porto Instituto de Ciências pays non établi dans la noticeUniversité ou école supérieure
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Centro de Estudos de Ciencia Animal pays non établi dans la noticeStructure de recherche
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Cooperativa de Ensino Superior Politécnico e Universitário pays non établi dans la noticeUniversité ou école supérieure
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Centro de Investigação Interdisciplinar em Sanidade Animal pays non établi dans la noticeStructure de recherche
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Arrábida Veterinary Hospital pays non établi dans la noticeÉtablissement de santé
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Faculty of Veterinary Medicine pays non établi dans la noticeUniversité ou école supérieure
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Superior School of Health pays non établi dans la noticeUniversité ou école supérieure
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Associate Laboratory for Animal and Veterinary Science (AL4AnimalS) pays non établi dans la noticeStructure de recherche
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Instituto Universitário de Ciências da Saúde (IUCS) pays non établi dans la noticeStructure de recherche
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CIISA - Centro Interdisciplinar-Investigáo em Saúde Animal pays non établi dans la noticeInstitution
Universidade Lusófona, University of Lisbon et Instituto de Ciências — Universidade do Porto, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.