Ip Tim Lau

Type 2 diabetes pathway-specific polygenic risk scores elucidate heterogeneity in clinical presentation, disease progression and diabetic complications in 18,217 Chinese individuals with type 2 diabetes

Gechang Yu, Claudia H.T. Tam, Cadmon K.P. Lim, Mai Shi et autres

Abstract Aims/hypothesis Type 2 diabetes is a complex and heterogeneous disease and the aetiological components underlying the heterogeneity remain unclear in the Chinese and East Asian population. Therefore, we aimed to investigate whether specific pathophysiological pathways drive the clinical heterogeneity in type …

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Circulating metabolomic markers linking diabetic kidney disease and incident cardiovascular disease in type 2 diabetes: analyses from the Hong Kong Diabetes Biobank

Qiao Jin, Eric S. H. Lau, Andrea O. Y. Luk, Claudia H.T. Tam et autres

AIMS/HYPOTHESIS: The aim of this study was to describe the metabolome in diabetic kidney disease (DKD) and its association with incident CVD in type 2 diabetes, and identify prognostic biomarkers. METHODS: ) or severely increased albuminuria with each metabolite were examined using …

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Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes

Claudia H.T. Tam, Cadmon K.P. Lim, Andrea O. Y. Luk, Mai Shi et autres

Objective: This study aims to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. Research Design and Methods: We performed a two-stage genome-wide association studies for CHD in Chinese patients with T2D (3,596 cases …

hk, cn, ca (code pays fourni par la source)

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes

Claudia H.T. Tam, Cadmon K.P. Lim, Andrea O. Y. Luk, Mai Shi et autres

Objective: This study aims to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. Research Design and Methods: We performed a two-stage genome-wide association studies for CHD in Chinese patients with T2D (3,596 cases …

hk, cn (code pays fourni par la source)

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes

Cadmon K.P. Lim, Andrea O. Y. Luk, Mai Shi, Hoi Man Cheung et autres

OBJECTIVE: In this study we aim to unravel genetic determinants of coronary heart disease (CHD) in type 2 diabetes (T2D) and explore their applications. RESEARCH DESIGN AND METHODS: We performed a two-stage genome-wide association study for CHD in Chinese patients with T2D …

hk, cn, ca, mo, au (code pays fourni par la source)

High-density lipoprotein subclasses and cardiovascular disease and mortality in type 2 diabetes: analysis from the Hong Kong Diabetes Biobank

Qiao Jin, Eric S. H. Lau, Andrea O. Y. Luk, Claudia H.T. Tam et autres

OBJECTIVE: High-density lipoproteins (HDL) comprise particles of different size, density and composition and their vasoprotective functions may differ. Diabetes modifies the composition and function of HDL. We assessed associations of HDL size-based subclasses with incident cardiovascular disease (CVD) and mortality and their …

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Clinical Predictors and Long-term Impact of Acute Kidney Injury on Progression of Diabetic Kidney Disease in Chinese Patients With Type 2 Diabetes

Guozhi Jiang, Andrea O. Y. Luk, Claudia H.T. Tam, Risa Ozaki et autres

We aim to assess the long-term impact of acute kidney injury (AKI) on progression of diabetic kidney disease (DKD) and all-cause mortality and investigate determinants of AKI in Chinese patients with type 2 diabetes (T2D). A consecutive cohort of 9,096 Chinese patients …

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Clinical predictors and long-term impact of acute kidney injury on progression of diabetic kidney disease in Chinese patients with Type 2 diabetes

Guozhi Jiang, Andrea O. Y. Luk, Claudia H.T. Tam, Risa Ozaki et autres

We aim to assess the long-term impact of AKI on progression of diabetic kidney disease and all-cause mortality, and investigate determinants of AKI in Chinese patients with type 2 diabetes (T2D). A consecutive cohort of 9,096 Chinese patients with T2D from the …

Clinical predictors and long-term impact of acute kidney injury on progression of diabetic kidney disease in Chinese patients with Type 2 diabetes

Guozhi Jiang, Andrea O. Y. Luk, Claudia H.T. Tam, Risa Ozaki et autres

We aim to assess the long-term impact of AKI on progression of diabetic kidney disease and all-cause mortality, and investigate determinants of AKI in Chinese patients with type 2 diabetes (T2D). A consecutive cohort of 9,096 Chinese patients with T2D from the …

Nonalbuminuric Diabetic Kidney Disease and Risk of All-Cause Mortality and Cardiovascular and Kidney Outcomes in Type 2 Diabetes: Findings From the Hong Kong Diabetes Biobank

Qiao Jin, Andrea O. Y. Luk, Eric S. H. Lau, Claudia H.T. Tam et autres

Rationale & Objective Nonalbuminuric diabetic kidney disease (DKD) has become the prevailing DKD phenotype. We compared the risks of adverse outcomes among patients with this phenotype compared with other DKD phenotypes. Study Design Multicenter prospective cohort study. Settings & Participants 19,025 Chinese …

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Unilateral adrenalectomy for aldosterone‐producing adenoma in Hong Kong: Outcomes and factors predicting resolution of hypertension

Hoi‐Tik Leung, Wai–Cheung Yuen, Brian Hung‐Hin Lang, Kathryn Choon Beng Tan et autres

Abstract Objective To evaluate surgical outcomes of patients with aldosterone‐producing adenoma (APA) over a 6‐year period from 2009 to 2014 in Hong Kong, and to derive a new scoring system to predict cure of hypertension after surgery. Methodology This was a retrospective …

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Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

Claudia H.T. Tam, Cadmon K.P. Lim, Andrea O. Y. Luk, Alex C.W. Ng et autres

Abstract Background The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear. Methods We used data from Biobank Japan (n = 70,657–128,305) and developed novel East Asian-specific genome-wide polygenic risk scores (PRSs) …

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