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2023
article
Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study
Rajiv Dave, Beatrix Elsberger, Vicky P. Taxiarchi, Ashu Gandhi, Cliona Kirwan, Baek Kim, Elizabeth Camacho, Charlotte E. Coles, Ellen Copson, Alona Courtney, Kieran Horgan, Patricia Fairbrother, Chris Holcombe, Jamie J Kirkham, Daniel Leff, Stuart McIntosh, Rachel O’Connell, Ricardo Pardo, Shelley Potter, Tim Rattay, Nisha Sharma, Raghavan Vidya, Ramsey Cutress, Abbas Imran, Abdalla Saad Abdalla Al‐Zawi, Abeera Abbas, Ada Chrysafi, Adam Critchley, Adam Walsh, Ahmed Hamad, Ajay Sahu, Alex Knight, Alexandra Humphreys, Ali Salih, Alice Chambers, Alice Moody, Alsarah Diab, Amanda Taylor, Amanda Thorne, Amani Asour, Amit Agrawal, Amit Goyal, Amtul R. Carmichael, Amtul Sami, Andreas Larentzakis, Andrew Pieri, Angeline Tanhueco, Anita Hargreaves, Anita Sharma, Anjana Satpathy, Anna Heeney, Anna Hurley, Anne Tansley, Antonio Piñero, Anu Sandhya, Anu Shrotri, Anup Sharma, Anushka Chaudhry, A Gvaramadze, Aonghus Ansari, A Kattakayam, Arnold D. Hill, Asha Adwani, Ashok Chouhan, Ashutosh Kothari, Ashvina Segaran, Atanu Ray, Bahar Mirshekar-Syahkal, Bahaty Riogi, Bashar Zeidan, Bernadette Pereira, Brian Hogan, Brian Isgar, Carl Podesta, Carol-Ann Courtney, Caroline Mortimer, Caroline Pogson, Catherine Krzyzanowska, Cátia Felício, Channegowda Navin, Charles Zammit, Charlotte Ives, Charlotte Kallaway, Cheryl Lobo, Chloe Williams, C Laban, Christopher W. J. Cartlidge, Christopher J. Wilson, Ciara McGoldrick, Ciaran Hollywood, Claire Rutherford, Claudia Harding-Mackean, Claudiu Simonca, Colm Power, D. H. B. Ubayawansa, Dalia Elfadl, David Dodwell, D.M. Sibbering, David A. Rew, Deepika Akolekar, Demetrios Hadjiminas, Dionysios-Dennis Remoundos, Dheer Singh Rana, Diana Gonçalves, Dibendu Betal, Dibyesh Banerjee, Dinesh Thekkinkattil, Disha Mehta, Donna Egbeare, Dorin Dumitru, Douglas Ferguson, Duraisamy Ravichandran, E Rahman, Edel Quinn, Edward R. C. St John, Eiman Khalifa, El-Rasheed Abdalla, Elaine Borg, Elaine Hyett, Eleanore Massey, Eleni Ntakomyti, Eleri Davies, Eliana Kalakouti, Elizabeth Clayton, Elizabeth Smyth, Ellora Barua, Emanuele Garreffa, Emma de Sousa, Emma MacInnes, Ennio Agabiti, Erum Najeeb, Evangelos Mallidis, Fabio Rapisarda, Farrokh Pakzad, Fathi Salem, Fayyaz Mazari, Firas Alkistawi, F.S. Kenny, Frank Trollman, Gael MacLean, Gareth Irwin, George Boundouki, Georgette Oni, Georgios Exarchos, Georgios Karagiannidis, Gerald Gui, Geraldine M. Mitchell, Gillian Clayton, Giulio Cuffolo, Giuseppina Mondani, Gordon Urquhart, Hannah Knowles, Haresh Devalia, Hazem Khout, Helen Dent, Helen Sweetland, Helen Mathers, Henrique Mora, Henry Cain, Henry Robb, Hiba Fatayer, Hisham Hamed, Hudhaifah Shaker, Hussein Tuffaha, Hyunjin Shin, Iain Brown, Ian Daltrey, Ian Whitehead, Ian Young, Iman Azmy, Inga Peerlink, Irene Athanasiou, Irene Osorio Silla, Isabella Dash, James Bentley, James P. Cook, James Harvey, Jamie McIntosh, Jamie Vatish, Jane Aitken, Jane Ooi, Jane Ralph, Jane Turner, Jarin Noronha, Jarosław Krupa, Jasdeep Gahir, J. Gill, Jennifer Rusby, Jennifer Isherwood, Jennifer Long, Jennifer D. Peck, Jenny Banks, Jeremy Batt, Jibril Jibril, Jo Mondani, Joanna Franks, Joanna Seward, John R. Benson, John Murphy, Jonathan Horsnell, Jonathan N. Lund, J Selmani, José Ignacio Sánchez-Méndez, Joseph Maalo, Julia Henderson, Julia Massey, Julie Doughty, Julie Dunn, Kalliope Valassiadou, Kamal Pushdary, Karen Bosch, Karen James, Karina Cox, Karyn Shenton, Kat McEvoy, Katalin Zechmeister, Katarina Lakatosova, Kate Williams, Katharine Kirkpatrick, Katherine Fairhurst, Katherine Krupa, Kathryn E. Harborough, Katy Hogben, Kelly Lambert, Kelvin Kam Lung Chong, Khalid Amin, Kristjan Asgeirsson, Kwok‐Leung Cheung, Leena Chagla, Lisa Whisker, Loraine Kalra, Lorna Cook, Louise Alder, Louise Merker, Lubna Noor, Lucie Jones, Lucy R. Khan, Lydia Prusty, Lyndsey Highton, M. Bilal Elahi, Maged Hussien, Mairead Savage, Mairi Fuller, Manoj Gowda, Maria Bramley, Maria Callaghan, M. Vernet-Tomás, Maria Verroiotou, Marta Jiménez Gómez, Massimiliano Cariati, Masuma Sarker, M Hague, Matthew Rowland, Michael Faheem, Michael J. Allen, Michelle Mullan, Mike Shere, Mina Girgis, Mina Youssef, Mini V. Sardar, Mohamed Elamass, Mohamed Elkorety, Mohamed Lafi, M Sait, Mohammad Sharif, Mohammed Absar, Mohsin Dani, Mona Sulieman, Monika Kaushik, Muhammad Salman, Musa Barkeji, M. Chandrashekar, Nabila Nasir, Nader Touqan, Nadine Betambeau, Nathan Coombs, Neil Johns, Neill Patani, Ngee-Ming Goh, Nicholas Gallegos, Nicholas H. G. Holford, Nick Abbott, Nicola Barnes, Nicola Laurence, Nicola Roche, N Dimopoulos, Nikolaos V. Michalopoulos, Norah Scally, Noyko Stanilov, Nur Amalina Che Bakri, Oladapo Fafemi, Olubunmi Odofin, Panagiotis Kokoropoulos, Pankaj G. Roy, Parto Forouhi, Paul Thiruchelvam, Pawel Trapszo, Penelope McManus, Peter Barry, Péter Liptay-Wagner, Peter Mallon, Petros Charalampoudis, Philip Drew, Philip Turton, Pilar Matey, Polly King, Polly Partlett, Primeera Wignarajah, Rachel Ainsworth, Rachel English, Rachel A. Foster, Rachel Soulsby, Rachel Tillett, Rachel Lee, Radhika Chadha, Ragheed Al-Mufti, Raj Achuthan, Raja Eid, Rajaram Burrah, Rajiv Vashisht, Rajive Nair, Ralia Bunza, Raman Vinayagam, Rami Tabbakh, Raouef Ahmed Bichoo, Rathi Rathinaezhil, Rebekah Law, Reem Salman, Reginald Salvador, Riccardo Bonomi, Richard E. Johnson, Richard Sutton, Rishikesh Parmeshwar, Ritchie Chalmers, Ritika Rampal, Rob Hardy, R.D. Macmillan, Robert L. Thomas, Rogelio Andrés-Luna, Rosamond Jacklin, R Simson, Russell Mullen, Ruth M. James, Ruvinder Athwal, Saed Ramzi, Sabrina Bezzaa, Sadaf Jafferbhoy, Sam Jeffreys, Samantha Sloan, Samantha Williams, Samir Laali, Samy Shaheed, Sanjay Joshi, Sankaran Chandrasekharan, Sankaran Narayanan, Santosh K. Somasundaram, Sarah Barker, Sarah Horne, Sascha Dua, S. Govindarajulu, Saung Hnin Phyu, Sekhar Marla, Senthurun Mylvaganam, Shabbir Poonawala, Shamaela Waheed, Sharat Chopra, Sharon Wallace, Sheila Shokuhi, Sheila Stallard, Sherif Monib, Shireen McKenzie, Simon Harries, Simon Hawkins, Simon Marsh, Simon Pain, Simon Pilgrm, Simon Smith, Simon Thomson, Siobhán Rooney, Sisse Olsen, Soni Soumian, Sonia Bathla, Stacy Wardle, Stephanie Jenkins, Stephen J. McCulley, Stuart Robertson, Sumit Goyal, Sumohan Chatterjee, Sunita Saha, Susan Williams-Jones, Syeda Nadia Shah Gilani, Tamara Kiernan, Tania S. de Silva, Tapan Sircar, Tasha Gandamihardja, Theodoros Sidiropoulos, T. W. F. Stroud, Tin Sein, Toral Gathani, Tracey Irvine, Tuabin Rasheed, Urvashi Jain, Usama Suleiman, U Andaleeb, Vallipuran Gopalan, Vasileios I. Sakellariou, Venla Kantola, Vinod Mathen, Wail Al Sarakbi, Walid Sasi, Wendy Sotheran, William Allum, Yasmin Wahedna, Yazan Masannat, Youhana Mikhael, Yousuf Sabah, Zaid Al-Ishaq, Zarghuna Taraki, Zenon Rayter, Abigail Tomlins, Alda Maria Correia, Amir M. Sharif, André Magalhães, Anjana Sathpathy, Asma Al-Allak, Aurea Manso de Lema, Bashar Zedian, Balendra Kumar, Brendan Smith, Caroline Richardson, Chandra N. Sekharan, Chloe Constantinou, Chris Wayte, Christina Summerhayes, Clare Fowler, Claire Murphy, C. Rogers, Covadonga Martí Álvarez, Douglas Macmillan, Eamonn Coveney, Eleanor Gutteridge, Eleftheria Kleidi, Elisa York Pineda, Fernando Osório, Fiona Court, Francis M. Kenny, Gary Osborn, Georgina Yiasoumis, Gloria Petralia, Harleen Deol, Richard Hunt, J.F.R. Robertson, José Luís Fougo, Lara Miralles Olivar, Laura Johnson, Mahwash Baber, Marcel Segura Badía, M. D. Zaker Ullah, D. Hassanally, N Dunne, Susie Connolly, Mohsin El-Gammal, Brendan Skelly, Ibrahim Ahmed, Peter Crane, Lucy Satherley, Tracey Simoes, Natarajan Vaithilingam, Nikolaos Arkadopoulos, Nikolaos Danias, Núria Argudo, P. Macmanus, Pantelis Vassiliu, Pau Nicolau Batalla, Pilar Auñón, Sarah Vestey, Sarah Tang, Sergio Salido, Shweta Aggarwal, Simon Pilgrim, Susy Costa, Zoë Winters
5Citations signalées — pas une note de qualité
23Institutions déclarées
1Pays d’affiliation déclarés
Résumé fourni par la source
PURPOSE: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst they were awaiting surgery due to reprioritisation of resources. METHODS: This multicentre, multinational cohort study recruited 6045 patients from the UK, Spain and Portugal during the peak pandemic period (Feb-July 2020). Patients on BrET were followed up to investigate the duration of, and response to, BrET. This included changes in tumour size to reflect downstaging potential, and changes in cellular proliferation (Ki67), as a marker of prognosis. RESULTS: 1094 patients were prescribed BrET, over a median period of 53 days (IQR 32-81 days). The majority of patients (95.6%) had strong ER expression (Allred score 7-8/8). Very few patients required expedited surgery, due to lack of response (1.2%) or due to lack of tolerance/compliance (0.8%). There were small reductions in median tumour size after 3 months' treatment duration; median of 4 mm [IQR - 20, 4]. In a small subset of patients (n = 47), a drop in cellular proliferation (Ki67) occurred in 26 patients (55%), from high (Ki67 ≥ 10%) to low (< 10%), with at least one month's duration of BrET. DISCUSSION: This study describes real-world usage of pre-operative endocrine therapy as necessitated by the pandemic. BrET was found to be tolerable and safe. The data support short-term (≤ 3 months) usage of pre-operative endocrine therapy. Longer-term use should be investigated in future trials.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study
- Date Crossref
- 03/04/2023
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
COVID-19 and healthcare impactsBreast Cancer Treatment StudiesAdvanced Breast Cancer Therapies