Julie Doughty

Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima Abbas, Kaja Abbas et autres

BACKGROUND: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital …

Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima Abbas, Jonathan R. Abbas et autres

BACKGROUND: Molnupiravir and nirmatrelvir-ritonavir are oral antivirals that have shown efficacy in preventing disease progression in outpatients with COVID-19. We aimed to evaluate these treatments for patients hospitalised with COVID-19 pneumonia, for whom data on these antivirals are scarce. METHODS: The RECOVERY …

Type of axillary surgery in node positive patients after neoadjuvant chemotherapy does not influence breast cancer specific survival - A regional audit of 10 years in the West of Scotland

Gemma Taylor, László Romics, Julie Doughty, James Mansell et autres

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Exploring the association between post-operative complications, disease-recurrence & mortality in primary operable breast cancer—systematic review & meta-analysis

Mhairi Mactier, Laura Arthur, Joanne Edwards, Julie Doughty et autres

Background: Post-operative complications (POCs) affect 36.1% of breast cancer patients. POCs are associated with inferior oncological outcomes in gastro-intestinal, lung, and head and neck cancers. Evidence is less clear in breast cancer. The James Lind Alliance demonstrated the importance of exploring risk …

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Survival after standard or oncoplastic breast-conserving surgery versus mastectomy for breast cancer

Mhairi Mactier, James Mansell, Laura Arthur, Julie Doughty et autres

BACKGROUND: Recent evidence suggests a survival advantage after breast-conserving surgery compared with mastectomy. Previous studies have compared survival outcomes after standard breast-conserving surgery, but no studies have compared survival outcomes after oncoplastic breast-conserving surgery. The aim of this study was to compare …

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Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima Abbas, Jaffar Abbas et autres

Background: Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not receiving ventilatory support (the combination of non-invasive …

Development and external validation of the ‘Global Surgical-Site Infection’ (GloSSI) predictive model in adult patients undergoing gastrointestinal surgery

McLean KA, Knight SR, Nina M. Clark, Adesoji Ademuyiwa et autres

Abstract Background Identification of patients at high risk of surgical-site infections may allow surgeons to minimize associated morbidity. However, there are significant concerns regarding the methodological quality and transportability of models previously developed. The aim of this study was to develop a …

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OUTCOME FOLLOWING BREAST CONSERVING THERAPY FOR DUCTAL CARCINOMA IN SITU (DCIS) IN THE WEST OF SCOTLAND

Katie Bennett, Rachel Morris, E. Mallon, J. Campbell et autres

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The impact of axillary surgery for adjuvant treatment decision making in woman over 70 with low-risk, early-stage breast cancer

Samantha Ng, László Romics, Christopher J. Wilson, Julie Doughty et autres

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The role of cavity shavings in patients undergoing breast conserving surgery (BCS) for ductal carcinoma in situ (DCIS)

Rachel Morris, Katie Bennett, E. Mallon, J. Campbell et autres

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Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial

Saul N. Faust, Richard Haynes, Christine E. Jones, Natalie Staplin et autres

BACKGROUND: Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 (PIMS-TS), also known as multisystem inflammatory syndrome in children (MIS-C) emerged in April, 2020. The paediatric comparisons within the RECOVERY trial aimed to assess the effect of intravenous immunoglobulin or corticosteroids compared with …

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Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima Abbas, Jonathan R. Abbas et autres

BACKGROUND: Empagliflozin has been proposed as a treatment for COVID-19 on the basis of its anti-inflammatory, metabolic, and haemodynamic effects. The RECOVERY trial aimed to assess its safety and efficacy in patients admitted to hospital with COVID-19. METHODS: In the randomised, controlled, …