Accès ouvert déclaré
2023
article
Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
Steffen Ullitz Thorsen, Xiang Liu, Yachana Kataria, Thomas Mandrup‐Poulsen, Simranjeet Kaur, Ulla Uusitalo, Suvi Μ. Virtanen, Jill M. Norris, Marian Rewers, William Hagopian, Jimin Yang, Jin‐Xiong She, Beena Akolkar, Stephen S. Rich, Carin Andrén Aronsson, Åke Lernmark, Anette‐Gabriele Ziegler, Jorma Toppari, Jeffrey P. Krischer, Hemang Parikh, Christina Ellervik, Jannet Svensson, Aaron Barbour, Kimberly Bautista, Judith Baxter, Daniel Felipe-Morales, Brigitte I. Frohnert, Marisa Stahl, Patricia Gesualdo, Michelle Hoffman, Rachel Karban, Edwin Liu, Alondra Munoz, Holly O’Donnell, Stesha Peacock, Hanan Shorrosh, Andrea K. Steck, Megan Stern, Kathleen Waugh, Olli Simell, Annika Adamsson, Suvi Ahonen, Iris Erlund, Sirpa Anttila, Leena Hakola, Anne Hekkala, Tiia Honkanen, Heikki Hyöty, Jorma Ilonen, Jaakko J. Koskenniemi, Miia Kähönen, Mikael Knip, Minna-Liisa Koivikko, Katja Kokkonen, Merja Koskinen, Mirva Koreasalo, Kalle Kurppa, Salla Kuusela, Jutta E. Laiho, Tiina Latva-aho, Laura Leppänen, Katri Lindfors, Maria Lönnrot, Elina Mäntymäki, Markus Mattila, Maija E. Miettinen, Teija Mykkänen, Tiina Niininen, Sari Niinistö, Sami Oikarinen, Hanna-Leena Oinas, Paula Ollikainen, Zhian Othmani, Aino Pitkänen, Sirpa Pohjola, Jenna Rautanen, Anne Riikonen, Minna Romo, Nelli Rönkä, Satu Simell, Päivi Tossavainen, Mari Vähä-Mäkilä, Eeva Varjonen, Riitta Veijola, Irene Viinikangas, Silja Vilmi, Richard McIndoe, Desmond Schatz, Diane Hopkins, Michael J. Haller, Risa Bernard, Melissa Gardiner, Ashok Sharma, Laura M. Jacobsen, Ashley DePeiza, Jennifer Hosford, Kennedy Petty, Leah Schust Myers, Anette G. Ziegler, Ezio Bonifacio, Cigdem Gezginci, Willi Grätz, Anja Heublein, Eva Hohoff, Sandra Hummel, Annette Knopff, Melanie Köger, Sibylle Koletzko, Claudia Ramminger, Roswith Roth, Jennifer Schmidt, Marlon Scholz, Joanna Stock, Katharina Warncke, Lorena Wendel, Christiane Winkler, Daniel Agardh, Rasmus Bennet, Corrado Cilio, Susanne Dahlberg, Ulla Fält, Malin Goldman Tsubarah, Emelie Ericson-Hallström, Lina Fransson, Thomas Gard, Emina Halilovic, Gunilla Holmén, Susanne Hyberg, Berglind Jónsdóttir, Naghmeh Karimi, Helena Elding Larsson, Marielle Lindström, Markus Lundgren, Marlena Maziarz, Jessica Melin, Caroline Nilsson, Yohanna Nordh, Kobra Rahmati, Anita Ramelius, Falastin Salami, Anette Sjöberg, Evelyn Tekum Amboh, Carina Törn, Ulrika Ulvenhag, Terese Wiktorsson, Åsa Wimar, Michael Killian, Claire Cowen Crouch, Jennifer Skidmore, Luka-Sophia Bowen, Mikeil Metcalf, Arlene Meyer, Jocelyn Meyer, Denise Mulenga, Nole Powell, Jared Radtke, Shreya Roy, Davey Schmitt, Preston Tucker, Dorothy Becker, Margaret Franciscus, MaryEllen Dalmagro-Elias Smith, Ashi Daftary, Mary Beth Klein, Chrystal Yates, Rajesh Adusumali, Sarah Austin-Gonzalez, Maryouri Avendano, Sandra Baethke, Brant Burkhardt, Martha Butterworth, Nicholas Cadigan, Joanna Clasen, Kevin Counts, Laura Gandolfo, Jennifer Garmeson, Veena Gowda, Christina Karges, Shu Liu, Kristian Lynch, Jamie Malloy, Lazarus Mramba, Cristina McCarthy, José L. Moreno, Cassandra Remedios, Chris Shaffer, Noah Sulman, Roy Tamura, Dena Tewey, Henri Thuma, Michael J. Toth, Kendra Vehik, Ponni Vijayakandipan, Melissa Wroble, Kenneth C. Young, Michael Abbondondolo, Lori Ballard, Rasheedah Brown, David Cuthbertson, Stephen Dankyi, Christopher Eberhard, Steven Fiske, David Hadley, Kathleen Heyman, Belinda Hsiao, Francisco Perez Laras, Hye‐Seung Lee, Qian Li, Colleen Maguire, Wendy McLeod, Aubrie Merrell, Steven Meulemans, Ryan Quigley, Laura Smith, Liping Yu, Dongmei Miao, Kathleen M. Gillespie, Kyla Chandler, Ilana Kelland, Yassin Ben Khoud, Matthew Randell, Wei‐Min Chen, Suna Önengüt-Gümüşcü, Emily Farber, Rebecca Roche Pickin, Jonathan M. Davis, Jordan P. Davis, Dan Gallo, Jessica Bonnie, Paul Campolieto, Sandra Ke, Niveen Mulholland, Thomas Briese, Todd M. Brusko, Suzanne Bennett Johnson, Eoin McKinney, Tomi Pastinen, Eric W. Triplett
8Citations signalées — pas une note de qualité
26Institutions déclarées
5Pays d’affiliation déclarés
Résumé fourni par la source
OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron. RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake. CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study
- Date Crossref
- 03/03/2023
- Éditeur
- American Diabetes Association
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Diabetes and associated disordersPancreatic function and diabetesGenetic Associations and Epidemiology