Laura Smith

The link between improvement in sleep and depressed mood: Exploring the role of repetitive negative thinking and behavioural activation

Romola S. Bucks, Peter M. McEvoy, Bruce Campbell, Laura Smith et autres

There is extensive evidence supporting a link between poor sleep and worse depression outcomes. Moreover, improvement in sleep contributes to enhanced depression outcomes. However, processes underlying this sleep—depression link are unclear. The current study examined whether changes in potential underlying processes, namely …

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Unfolding the Mystery of Autoimmunity: The Environmental Determinants of Diabetes in the Young (TEDDY) Study

Marian Rewers, Daniel Agardh, Suzanne Bennett Johnson, Ezio Bonifacio et autres

In 2025, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health celebrates 75 years of leadership in diabetes research. The NIDDK serves people of the U.S. affected by or at risk for many chronic …

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Quantitative blood loss values reveal high rates of undiagnosed postpartum hemorrhage

Burhan Khan, Anna Jaeger, Gauri Shevatekar, Yanzhi Wang et autres

OBJECTIVE: In this study, we examined quantitative blood loss (QBL) values and postpartum hemorrhage (PPH) diagnoses in relation to clinical, demographic, and hospitalization related variables. METHODS: A retrospective chart review was conducted of deliveries at a regional hospital over a nine-month period, …

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Early Appearance of Thyroid Autoimmunity in Children Followed From Birth for Type 1 Diabetes Risk

Joanna Clasen, Kendra Vehik, Åke Lernmark, Markus Lundgren et autres

CONTEXT: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define preclinical autoimmune thyroid disease (AITD), which can progress to either clinical hypothyroidism or hyperthyroidism. OBJECTIVE: We determined the age at seroconversion in children genetically at risk for type 1 diabetes. METHODS: TPOAb …

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Cross-setting Comparison of Risk Factors for Pressure Injuries Acquired in Post-Acute Care

Daniel H. Barch, Julie Seibert, Amy Kandilov, Amarilys Bernacet et autres

GENERAL PURPOSE To provide information on the association between risk factors and the development of new or worsened stage 2 to 4 pressure injuries (PIs) in patients in long-term care hospitals (LTCHs), inpatient rehabilitation facilities (IRFs), and skilled nursing facilities (SNFs). TARGET …

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Encapsulated papillary carcinoma with conventional papillary ductal carcinoma in situ in a male breast

Rasheed Elayyan, Laura Smith, Sue Down

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Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Nicholas Avellaneda, Mahmoud Al Masri, Abylai Baimakhanov, D Balasubramaniam et autres

BACKGROUND: Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. METHODS: The internationally …

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Early Expected Discharge Date Accuracy During Hospitalization: A Multivariable Analysis

Nicholas Piniella, Theresa E. Fuller, Laura Smith, Hojjat Salmasian et autres

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Physical Activity and the Development of Islet Autoimmunity and Type 1 Diabetes in 5- to 15-Year-Old Children Followed in the TEDDY Study

Xiang Liu, Suzanne Bennett Johnson, Kristian Lynch, Kerry Cordan et autres

OBJECTIVE: This study investigated physical activity and its association with the development of islet autoimmunity and type 1 diabetes in genetically at-risk children aged 5-15 years. RESEARCH DESIGN AND METHODS: As part of the longitudinal Environmental Determinants of Diabetes in the Young …

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Data from In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

Orli Yogev, Gilberto S. Almeida, Karen Barker, Sally L. George et autres

Abstract Neuroblastoma is a pediatric cancer that is frequently metastatic and resistant to conventional treatment. In part, a lack of natively metastatic, chemoresistant in vivo models has limited our insight into the development of aggressive disease. The Th-MYCN genetically engineered mouse model …

Supplementary Fig. 3 from In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

Orli Yogev, Gilberto S. Almeida, Karen Barker, Sally L. George et autres

Resistant tumors show recurrent copy number aberrations and a tendency towards the neuroblastoma mesenchymal gene expression signature.

Supplementary Data from In Vivo Modeling of Chemoresistant Neuroblastoma Provides New Insights into Chemorefractory Disease and Metastasis

Orli Yogev, Gilberto S. Almeida, Karen Barker, Sally L. George et autres

Supplementary materials and methods Supplementary figures legends