Accès ouvert déclaré
2020
article
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Aliki‐Eleni Farmaki, Jennie Hui, Jürgen Gräßler, Peter J. van der Most, Ryan W. Walker, L Adrienne Cupples, Oddgeir L. Holmen, Maija Hassinen, Oluf Pedersen, Peter Lichtner, Ioanna Tachmazidou, Hans L. Hillege, Angelo Tremblay, Arthur W. Musk, Nancy L. Heard‐Costa, Thorkild I. A. Sørensen, Uwe Völker, Sylvain Sebért, Joel Eriksson, Claire Bellis, Gonneke Willemsen, Yii‐Der Ida Chen, Albert Hofman, James S. Pankow, Jennifer E. Huffman, Michael Boehnke, Janina M. Jeff, Lu Qi, Unnur Þorsteinsdóttir, David J. Hunter, Janina S. Ried, Keri L. Monda, Joel N. Hirschhorn, Matti Uusitupa, Niels Grarup, Erika Salvi, Mark I. McCarthy, Markku Laakso, Alan F. Wright, Mary F. Feitosa, Kāri Stefánsson, Elisabeth Widén, Nele Friedrich, Jeffrey R. O’Connell, Theodosios Kyriakou, Valeriya Lyssenko, Eleftheria Zeggini, Alexander Teumer, Anne E. Justice, Gemma Cadby, Frank B. Hu, Jaana Lindström, Kay Tee Khaw, Péter Kovács, Johanne Marie Justesen, Wendy L. McArdle, Sara M. Willems, Heather M. Stringham, May E. Montasser, Diana Kuh, Aaron Isaacs, Maria Karaleftheri, Robert A. Scott, Rainer Rauramaa, Eero Jokinen, David Schlessinger, Maria Grazia Pilia, Kari E. North, Ken K. Ong, Till Ittermann, Roberto Lorbeer, Alexessander Couto Alves, Veikko Salomaa, Robert Luben, Catharina A. Hartman, Claude Bouchard, Nigel W. Rayner, Caroline Hayward, Rao, Paul M. Ridker, Annette Peters, Kristian Hveem, Marie‐Claude Vohl, Rasmus Ribel‐Madsen, Eva Albrecht, Tom Wilsgaard, Mattias Lorentzon, Caroline S. Fox, Lyle J. Palmer, Ronald P. Stolk, Carola Zillikens, Kathleen Stirrups, Lorraine Southam, Daniel I. Chasman, Nita G. Forouhi, Tõnu Esko, Allan Linneberg, Nicholas D. Hastie, Sarah H. Wild, Aarno Palotie, Karen L. Mohlke, Nicholas J. Wareham, Timo A. Lakka, Heikki A. Koistinen, Lavinia Paternoster, Inga Prokopenko, Clive Osmond, Ben A. Oostra, Ingrid B. Borecki, Jaakko Tuomilehto, Jenny van Dongen, Francis S. Collins, Harald Grallert, Jennifer L. Bragg‐Gresham, Megan Therese Smith, Carolina Medina‐Gómez, Eric Boerwinkle, Gabriele Müller, Stefan R. Bornstein, Markku Heliövaara, Pekka Jousilahti, Leena Kinnunen, Jaspal S. Kooner, Amy J. Swift, Johanna Kuusisto, Ruth J. F. Loos, Jing Zhao, Tuomo Rankinen, Jagvir Grewal, Traci M. Bartz, Anders Hamsten, Angela Döring, Andrew A. Hicks, Reedik Mägi, Inger Njølstad, Igor Rudan, Treva Rice, David P. Strachan, Eco J. C. de Geus, Charleston W. K. Chiang, Hugh Watkins, Robert C. Kaplan, Matthias Blüher, Alena Standáková, Jian’an Luan, Daniele Cusi, Georg Homuth, Mark A. Sarzynski, Marjo‐Riitta Järvelin, Claes Ohlsson, Michael Stümvoll, Leif Groop, John C. Chambers, Anette P. Gjesing, Brenda W.J.H. Penninx, Marcel Bruinenberg, Konstantin Strauch, Gérard Waeber, Paul Knekt, Ivana Kolčić, Lise Lotte N. Husemoen, George Dedoussis, Anubha Mahajan, Krista Fischer, Audrey Y. Chu, Jari Lahti, Terho Lehtimäki, Andrew P. Morris, Ilja M. Nolte, Aki S. Havulinna, Timothy D. Spector, Véronique Vitart, Sirkka Keinänen‐Kiukaanniemi, Christian Gieger, Gonçalo R. Abecasis, Andres Metspalu, Serena Sanna, Bruce M. Psaty, Anuj Goel, Guðmar Þorleifsson, Salome Scholtens, Teresa Ferreira, Jorma Viikari, Alex Lewin, Nicola Glorioso, Barbara McKnight, Marcus Richards, Thomas W. Winkler, Harold Snieder, Satu Männistö, Mika Kähönen, Marie Neergaard Harder, Tomi Laitinen, Sven Bergmann, Albertine J. Oldehinkel, Claudia Langenberg, James F. Wilson, Louis Përusse, Zoltán Kutalik, Maria Dimitriou, Martin Farrall, Weihua Zhang, Anke Tönjes, Sophie R. Wang, Niek Verweij, Anne Jackson, Cecilia M. Lindgren, Lori L. Bonnycastle, Narisu Narisu, Niina Eklund, Martina Müller‐Nurasyid, Ozren Polašek, Ishminder K. Kooner, Irene Pichler, Peter P. Pramstaller, Jan Smit, Markus Perola, Emmanouil Tsafantakis, John Beilby, Fernando Rivadeneira, Thomas Sparsø, Valgerður Steinthórsdóttir, Mariaelisa Graff, Paolo Manunta, Jouke‐Jan Hottenga, Olli Raitakari, Irene Mateo Leach, Lili Milani, Morris A. Swertz, Dorret I. Boomsma, Laura M. Yerges-Armstrong, Tarunveer S. Ahluwalia, Erkki Vartiainen, John Blangero, Harry Campbell, André G. Uitterlinden, Hannu Puolijoki, Timothy M. Frayling, Antti Jula, Kati Kristiansson, Johan G. Eriksson, Ron T. Gansevoort, Iris M. Heid, Eero Kajantie, Stephan J. L. Bakker, Lynda M. Rose, Mathias Gorski, Massimo Mangino, Péter Vollenweider, Pim van der Harst, Cornelia M. van Duijn, Seppo Koskinen, Cristina Venturini, Jana V. van Vliet‐Ostaptchouk, Rebecca Mills, Torben Jørgensen, Evelin Mihailov, Liesbeth Vandenput, Alan R. Shudiner, Cristina Barlassina, Andrew T. Hattersley, Peter S. Chines, Torben Hansen, Francesca D’Avila, Panos Deloukas, Judith M. Vonk, Pirro G. Hysi, Stavroula Kanoni, Peter E. H. Schwarz, Shapour Jalilzadeh, Richard N. Bergman
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Le résumé fourni par la source
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
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Les sujets associés
Genetics and Physical Performance