David J. Hunter

Helicobacter pylori , herpes simplex virus‐1, varicella‐zoster virus, and dementia risk

Thomas J. Littlejohns, Wenyu Liu, Carol Brayne, Julia Butt et autres

Abstract Introduction Helicobacter pylori ( H. pylori ), herpes simplex‐1 (HSV‐1), and varicella‐zoster virus (VZV) could increase dementia risk; however, evidence from large cohorts with long‐term follow‐up is scarce. Methods Multivariable‐adjusted Cox proportional‐hazards models were used to investigate the association between H. …

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Mammographic density, pathogenic breast cancer susceptibility gene variants and breast cancer risk

Xiaomeng Zhang, Mikael Eriksson, Nasim Mavaddat, Joe Dennis et autres

Abstract Importance Mammographic density (MD) and pathogenic variants (PVs) in breast cancer susceptibility genes are major determinants of breast cancer risk, but their association and joint effects on breast cancer risk are unclear. Objective To investigate the association between the presence or …

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LONG-TERM MONITORING OF MALIGNANT AES IN TISSUEGENE-C (TG-C) WITH SAFETY DATA OVER 16 YEARS

David J. Hunter, Sun Jin Kim, Moon Jong Noh

au, us (code pays fourni par la source)

Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis

Jose E. Castelao, Julia Geisler, R.M. Tamimi, Maria Escala-Garcia et autres

Breast cancer metastasis accounts for most of the deaths from breast cancer. Identification of germline variants associated with survival in aggressive types of breast cancer may inform understanding of breast cancer progression and assist treatment. In this analysis, we studied the associations …

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Combined Associations of a Polygenic Risk Score and Classical Risk Factors with Breast Cancer Risk

Nasim Mavaddat, Minouk J. Schoemaker, Hiltrud Brauch, Thomas Brüning et autres

We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic …

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Perspective on this Article from A Large Prospective Study of SEP15 Genetic Variation, Interaction with Plasma Selenium Levels, and Prostate Cancer Risk and Survival

Kathryn L. Penney, Fredrick R. Schumacher, Haojie Li, Peter Kraft et autres

Perspective on this Article from A Large Prospective Study of SEP15 Genetic Variation, Interaction with Plasma Selenium Levels, and Prostate Cancer Risk and Survival

Perspective on this Article from A Large Prospective Study of SEP15 Genetic Variation, Interaction with Plasma Selenium Levels, and Prostate Cancer Risk and Survival

Kathryn L. Penney, Fredrick R. Schumacher, Haojie Li, Peter Kraft et autres

Perspective on this Article from A Large Prospective Study of SEP15 Genetic Variation, Interaction with Plasma Selenium Levels, and Prostate Cancer Risk and Survival

Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Siddhartha P. Kar, Jonathan Beesley, Ali Amin Al Olama, Kyriaki Michailidou et autres

Supplementary Grant Support

Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Siddhartha P. Kar, Jonathan Beesley, Ali Amin Al Olama, Kyriaki Michailidou et autres

Supplementary Figure S1. LocusZoom regional association plots for the seven new cross-cancer loci that were > 1 Mb from known index SNPs. Supplementary Figure S2A-B. Box plots showing eQTL associations between (A) rs9375701 and L3MBTL3 in normal breast and prostate tissues and …

Supplementary Acknowledgments from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Siddhartha P. Kar, Jonathan Beesley, Ali Amin Al Olama, Kyriaki Michailidou et autres

Supplementary Acknowledgments

Supplementary Grant Support from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Siddhartha P. Kar, Jonathan Beesley, Ali Amin Al Olama, Kyriaki Michailidou et autres

Supplementary Grant Support

Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types

Siddhartha P. Kar, Jonathan Beesley, Ali Amin Al Olama, Kyriaki Michailidou et autres

Supplementary Figure S1. LocusZoom regional association plots for the seven new cross-cancer loci that were > 1 Mb from known index SNPs. Supplementary Figure S2A-B. Box plots showing eQTL associations between (A) rs9375701 and L3MBTL3 in normal breast and prostate tissues and …