Interrelation between extracellular vesicles miRNAs with chronic lung diseases
Rattachement africain : in, cn, sa, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Extracellular vehicles (EVs) are nanoscale lipid bilayer vesicles that carry biologically active biomolecule cargos like proteins, lipids, and nucleic acids (DNA, RNA) outside of the cell. Blood (serum/plasma), urine, and bronchoalveolar lavage fluid are all examples of biofluids from which they may be collected. EVs play a vital role in intracellular communication. The molecular signature of EVs largely depends on the parental cell's status. EVs are classified into two groups, (1) exosomes (originated by endogenous route) and (2) microvesicles (originated from the plasma membrane, also known as ectosomes). The quantity and types of EV cargo vary during normal conditions compared to pathological conditions (chronic inflammatory lung diseases or lung cancer). Consequently, EVs contain novel biomarkers that differ based on the cell type of origin and during lung diseases. Small RNAs (e.g., microRNAs) are transported by EVs, which is one of the most rapidly evolving research areas in the field of EVs biology. EV-mediated cargos transport small RNAs that can result in reprograming the target/recipient cells. Multiple chronic inflammatory lung illnesses, such as chronic obstructive pulmonary disease, asthma, pulmonary hypertension, pulmonary fibrosis, cystic fibrosis, acute lung injury, and lung cancer, have been demonstrated to be regulated by EV. In this review, we will consolidate the current knowledge and literature on the novel role of EVs and their small RNAs concerning chronic lung diseases (CLDs). Additionally, we will also provide better insight into the clinical and translational impact of mesenchymal stem cells-derived EVs as novel therapeutic agents in treating CLDs.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Interrelation between extracellular vesicles miRNAs with chronic lung diseases
- Date Crossref
- 05/09/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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SRM Institute of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Amrita Vishwa Vidyapeetham pays non établi dans la noticeUniversité ou école supérieure
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Ramakrishna Mission Vivekananda Educational and Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Ramakrishna Mission Vivekananda Centenary College Department of Health Sciences Novel Global Community Educational Foundation Hebersham Australia pays non établi dans la noticeUniversité ou école supérieure
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Jinan University pays non établi dans la noticeUniversité ou école supérieure
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King Abdulaziz University Department of Medical Laboratory Sciences pays non établi dans la noticeUniversité ou école supérieure
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King Fahad Hospital Jeddah pays non établi dans la noticeÉtablissement de santé
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John Radcliffe Hospital Reproductive Health pays non établi dans la noticeÉtablissement de santé
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University of Oxford pays non établi dans la noticeUniversité ou école supérieure
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Cancer and Stem Cell Biology Laboratory pays non établi dans la noticeStructure de recherche
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Department of Health Sciences Novel Global Community Educational Foundation Hebersham Australia pays non établi dans la noticeOrganisation à but non lucratif
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Vaccines and Immunotherapy Unit King Fahad Medical Research Center Jeddah Saudi Arabia pays non établi dans la noticeStructure de recherche
SRM Institute of Science and Technology, Amrita Vishwa Vidyapeetham et Ramakrishna Mission Vivekananda Educational and Research Institute, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.