Raed F. Alserihi

Bridging the gap between knowledge and barriers: evaluating healthcare professionals' perspectives on hematopoietic stem cell transplantation

Haitham M.H. Qutob, Raed F. Alserihi

sa (code pays fourni par la source)

Bridging the Gap Between Knowledge and Barriers: Evaluating Healthcare Professionals' Perspectives on Hematopoietic Stem Cell Transplantation

Haitham M.H. Qutob, Raed F. Alserihi

sa (code pays fourni par la source)

Clinical exome sequencing identifies novel gene variants associated with ischemic stroke in the Saudi Tabuk population

Abdullah Hamadi, Rashid Mir, Osama M. Al‐Amer, Mohammed Alasseiri et autres

Background Variants linked to the risk of ischemic stroke have been discovered through genome-wide association studies (GWASs). These variations frequently have little consequences that lack apparent biological significance. Hence, these findings demonstrate that exome sequencing can be highly relevant to stroke, even …

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Understanding the Role of All-Trans Retinoic Acid in Acute Myeloid Leukemia Cells

Hadeel Al Sadoun, Fatimah Alamoudi, Noha Alamoudi, Hossam H. Tayeb et autres

Background: All-trans retinoic acid (ATRA) has revolutionized the management of acute promyelocytic leukemia (APL) and has generated interest in differentiation therapy as means to reduce reliance on conventional chemotherapy in other subtypes of acute myeloid leukemia (AML). However, the precise relationship between …

sa, ie (code pays fourni par la source)

Reduced folate carrier 1 (RFC1) gene polymorphisms among acute lymphoblastic leukemia patients

Mashaer Taha Edris, Maye M. Merghani, Shaza Salih Gafar, Ahmed Mohamed Asmeli et autres

Reduced Folate Carrier1 (RFC1) gene's metabolism is crucial for DNA synthesis, epigenetic mechanisms, and cellular methylation events. Nonetheless, RFC1 polymorphisms have drawn a lot of interest in current medical genetics studies. The objectives of the study were to ascertain the relationship between …

Soudan, sa, gb (code pays fourni par la source)

Methionine Synthase Reductase A66G Variant in Pediatric Acute Lymphoblastic Leukemia Patients

Elrashed B. Yasin, Haitham M.H. Qutob, Raed F. Alserihi

Background: Methionine synthase reductase, which is encoded by the methionine synthase reductase (MTRR) gene, plays a crucial role in the methylation reactions and the production of DNA and its epigenetic processes. There was a correlation between the MTRR (A66G) polymorphism and the …

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Molecular and hematological spectrum of α-thalassemia in Saudi patients

Raed F. Alserihi, Sarah Alswat, Heba Ahmed Alkhatabi, Haitham M.H. Qutob et autres

α-thalassemia (α-thal) is a genetic disorder characterized by a decreased synthesis of α-globin chains. A deletion mutation most often causes it in one or more α-globin chains. No comprehensive characterization studies have been conducted on α-thal patients in the Saudi population. Therefore, …

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Gene expression profiling on CML patients with Philadelphia translocation.

Heba Alkhatabi, S Aldahlawi, Mohannad S. Hazzazi, Reem Alsolami et autres

OBJECTIVE: The use of tyrosine kinase inhibitors (TKIs) and other targeted therapeutics plays a pivotal role in treatment management for individuals diagnosed with chronic myeloid leukemia (CML). However, some patients may experience fewer favorable outcomes and treatment resistance. Our work aims to …

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Association of methionine synthase reductase (MTRR A66G) polymorphism with susceptibility to acute lymphoblastic leukemia

Mashaer Taha Edris, Maye M. Merghani, Shaza Salih Gafar, Ahmed Mohamed Asmali et autres

Background and Objectives. The enzyme methionine synthase reductase is involved in cellular methylation reactions, DNA synthesis, and epigenetic processes. It is encoded by the MTRR gene, which garnered a lot of attention in current medical genetics research. This study was conducted to …

Soudan, sa (code pays fourni par la source)

The Quality of Blood Donation Services and Its Association with Blood Donors’ Trust and Loyalty at Makkah Blood Donation Centers in Saudi Arabia: A Cross-Sectional Study

Saeed M. Kabrah, Samer Abuzerr, Ruba Omar Mohammed Almaghrabi, Raed F. Alserihi et autres

The current cross-sectional study was conducted to determine the quality of blood donation services and its association with blood donors’ trust and loyalty at Makkah blood donation centers in Saudi Arabia. A total of 373 healthy blood donors aged ≥18 years who …

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Analysis of NPM1 and FLT3 Mutations in Patients with Acute Myeloid Leukemia in Jeddah, Saudi Arabia: A Pilot Study

Raed F. Alserihi, Hameeda Ahmad Hameeda Ahmad, Heba Alkhatabi Heba Alkhatabi, Talal Qadah et autres

Background: The outcome of acute myeloid leukemia (AML) is influenced by ethnicity, geographic variations, and the patient’s molecular profile. We aimed to explore the mutation frequencies of the nucleophosmin 1 (NPM1) and the FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) …

sa, Égypte (code pays fourni par la source)

Overexpression of Lmo2 initiates T-lymphoblastic leukemia via impaired thymocyte competition

Hesham Abdulla, Raed F. Alserihi, Christoffer Flensburg, Waruni Abeysekera et autres

Cell competition has recently emerged as an important tumor suppressor mechanism in the thymus that inhibits autonomous thymic maintenance. Here, we show that the oncogenic transcription factor Lmo2 causes autonomous thymic maintenance in transgenic mice by inhibiting early T cell differentiation. This …

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