Local and systemic responses to SARS-CoV-2 infection in children and adults
Rattachement africain : gb, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Children typically present with milder coronavirus disease 2019 (COVID-19) severity compared to adults. The molecular basis of the differences in COVID-19 progression between children and adults remains to be elucidated. Here we investigated the age-specific differences of airway mucosal immunology as well as systemic immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: We analysed matched nasal, tracheal and blood samples from healthy and COVID-19 patients from infancy to adulthood (n=93) by means of single cell multi-omic profiling. Results: In healthy children, airway mucosal immunity is in a pre-activated interferon state which is further induced in response to SARS-CoV2 infection. This higher local innate immune response in children could restrict disease progression. We identified novel epithelial cell states that associate with COVID-19 and age. The systemic immune response in children was characterised by increases in naive lymphocytes and greater clonotype diversity, while in adults was dominated by cytotoxic populations. Integration of matched nasal and blood data showed that interferon response in the airways correlate with the induction of novel systemic interferon-stimulated subpopulations within multiple immune cells, which were greatly reduced in children. Conclusions: Our study demonstrates multiple age-specific differences in airway and systemic response to SARS-CoV-2, reflecting the changes of the immune landscape over development. These insights could contribute to pinpointing the triggers of severe disease in adults with a view towards risk stratification and therapeutic intervention.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Local and systemic responses to SARS-CoV-2 infection in children and adults
- Date Crossref
- 10/03/2022
- Éditeur
- European Respiratory Society
- Type
- proceedings-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University College London Division of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Wellcome Sanger Institute pays non établi dans la noticeOrganisation à but non lucratif
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Great Ormond Street Hospital pays non établi dans la noticeÉtablissement de santé
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University College London Hospitals NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Royal Free London NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Northwestern University Division of Pulmonary and Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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Newcastle University Biosciences Institute pays non établi dans la noticeUniversité ou école supérieure
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University of Cambridge Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Wellcome/MRC Cambridge Stem Cell Institute pays non établi dans la noticeStructure de recherche
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NIHR Great Ormond Street BRC and Institute of Child Health pays non établi dans la noticeStructure de recherche
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Royal Free Hospital NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
Division of Medicine — University College London, Wellcome Sanger Institute et Great Ormond Street Hospital, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.