Accès ouvert
2026
preprint
OpenAlex
Puja Mehta, Connar M. Mawer, Gordon Beattie, David J. F. Smith et autres
Abstract Post-COVID-19 residual lung abnormalities (RLA) are associated with persistent respiratory symptoms and radiological changes, yet the underlying mechanisms remain unclear. We performed integrated multi-omic profiling of paired bronchoalveolar lavage and blood samples from patients with post-COVID-19 RLA and healthy controls, combining …
us, gb
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Josephine L. Barnes, Masahiro Yoshida, Peng He, Kaylee B. Worlock et autres
Studies of human lung development have focused on epithelial and mesenchymal cell types and function, but much less is known about the developing lung immune cells, even though the airways are a major site of mucosal immunity after birth. An unanswered question …
gb, jp, nl, kr, us, ru, au
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Kaylee B. Worlock, Rik G.H. Lindeboom, Lisa M. Dratva, Masahiro Yoshida et autres
Despite the rapid global COVID-19 research effort, our understanding of how and why some people go on to develop an infection upon SARS-CoV-2 viral exposure, whilst others do not, remains limited. The world’s first Human COVID-19 Challenge Study offers a unique opportunity …
gb, ca
(code pays fourni par la source)
Accès ouvert
2024
erratum
OpenAlex
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida et autres
In the version of the article initially published, the Acknowledgements was missing the following text, which has now been added to the HTML and PDF versions of the article: “The authors gratefully acknowledge support from the UK Vaccine Taskforce of the Department …
gb, nl, th
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida et autres
. Here in our SARS-CoV-2 human challenge study, we used single-cell multi-omics profiling of nasopharyngeal swabs and blood to temporally resolve abortive, transient and sustained infections in seronegative individuals challenged with pre-Alpha SARS-CoV-2. Our analyses revealed rapid changes in cell-type proportions and …
gb, nl, th
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Annabel J. Curle, Josephine L. Barnes, Robert Owen, Roger A. Barker et autres
The final United Kingdom Regenerative Medicine Platform (UKRMP) conference held in Edinburgh's iconic McEwan Hall between 8th and November 10, 2023 saw a gathering of nearly 200 international delegates presenting exceptional science and celebrating a decade of this initiative. The UKRMP had …
gb
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Josephine L. Barnes, Masahiro Yoshida, Peng He, Kaylee B. Worlock et autres
Studies of human lung development have focused on epithelial and mesenchymal cell types and function, but much less is known about the developing lung immune cells, even though the airways are a major site of mucosal immunity after birth. An unanswered question …
gb, jp, nl, kr, au
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Natsuhiko Kumasaka, Raghd Rostom, Ni Huang, Krzysztof Polański et autres
Common genetic variants across individuals modulate the cellular response to pathogens and are implicated in diverse immune pathologies, yet how they dynamically alter the response upon infection is not well understood. Here, we triggered antiviral responses in human fibroblasts from 68 healthy …
gb, jp, de, il
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Rik G.H. Lindeboom, Kaylee B. Worlock, Lisa M. Dratva, Masahiro Yoshida et autres
Abstract The COVID-19 pandemic is an ongoing global health threat, yet our understanding of the cellular disease dynamics remains limited. In our unique COVID-19 human challenge study we used single cell genomics of nasopharyngeal swabs and blood to temporally resolve abortive, transient …
gb, nl
(code pays fourni par la source)
2023
conference-abstract
OpenAlex
Kaylee B. Worlock, Robert Lindeboom, Masahiro Yoshida, Lisa M. Dratva et autres
Despite the rapid development and rollout of first-generation vaccines, COVID-19 remains an ongoing global health concern. Whilst single cell transcriptional studies have provided deep biological insights, limited longitudinal sampling has made temporal inferences difficult. The Human COVID-19 Challenge Study offers a unique …
gb
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Josephine L. Barnes, Peng He, Masahiro Yoshida, Kaylee B. Worlock et autres
Abstract During human development, lungs develop their roles of gas exchange and barrier function. Recent single cell studies have focused on epithelial and mesenchymal cell types, but much less is known about the developing lung immune cells, although the airways are a …
gb, jp
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G.H. Lindeboom et autres
Background: Children typically present with milder coronavirus disease 2019 (COVID-19) severity compared to adults. The molecular basis of the differences in COVID-19 progression between children and adults remains to be elucidated. Here we investigated the age-specific differences of airway mucosal immunology as …
gb, us
(code pays fourni par la source)