Henry Yung

Transcriptional and Morphological Analysis of Human Developing Pleura Reveals Age-Specific, Species-Specific and Visceral Versus Parietal Differences

Henry Yung, Ahmed S. N. Alhendi, Daniel J. Pearce, V. Teixeira et autres

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Local and systemic responses to SARS-CoV-2 infection in children and adults

Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G.H. Lindeboom et autres

Background: Children typically present with milder coronavirus disease 2019 (COVID-19) severity compared to adults. The molecular basis of the differences in COVID-19 progression between children and adults remains to be elucidated. Here we investigated the age-specific differences of airway mucosal immunology as …

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Local and systemic responses to SARS-CoV-2 infection in children and adults

Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G.H. Lindeboom et autres

. Here, to examine the differences between children and adults in their response to SARS-CoV-2 infection, we analysed paediatric and adult patients with COVID-19 as well as healthy control individuals (total n = 93) using single-cell multi-omic profiling of matched nasal, tracheal, …

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T1 The local and systemic response to SARS-CoV-2 infection in children and adults

Kaylee B. Worlock, Masaki Yoshida, Rik G.H. Lindeboom, Ni Huang et autres

Introduction and Objectives Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Whilst a substantial proportion of adults infected with SARS-CoV-2 progress to develop severe disease, children rarely manifest respiratory complications. However, the underlying …

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18P Precision radiotherapy for centrally located non-small cell lung cancer (NSCLC)

Eva YW Cheung, YH Chan, Ke Cheng, Y.T. Cheng et autres

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Biological basis for novel mesothelioma therapies

Joanna Obacz, Henry Yung, Marie Shamseddin, Emily Linnane et autres

Mesothelioma is an aggressive cancer that is associated with exposure to asbestos. Although asbestos is banned in several countries, including the UK, an epidemic of mesothelioma is predicted to affect middle-income countries during this century owing to their heavy consumption of asbestos. …

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Lung development

Jessica Allen-Hyttinen, Henry Yung, Marko Nikolić

The local and systemic response to SARS-CoV-2 infection in children and adults

Masahiro Yoshida, Kaylee B. Worlock, Ni Huang, Rik G.H. Lindeboom et autres

Abstract While a substantial proportion of adults infected with SARS-CoV-2 progress to develop severe disease, children rarely manifest respiratory complications. Therefore, understanding differences in the local and systemic response to SARS-CoV-2 infection between children and adults may provide important clues about the …

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Cardiac symptoms are a survival predictor in sarcoidosis

Theresia Mikolasch, Henry Yung, Muhunthan Thillai

Aim: To correlate presenting symptoms with a final diagnosis of cardiac sarcoid & determine prognostic characteristics for mortality Methods: Retrospective analysis of 503 consecutive patients with sarcoidosis presenting between 2006-2016 to Papworth & Cambridge University Hospitals. Cardiac symptoms (specifically syncope, palpitations, chest …

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Food for Thought: Dietary Intervention in a Rare Cause of Severe Ventilatory Failure

Henry Yung, Keshav Sharma, W. L. Flowers, Malcolm Marquette et autres

Plastic bronchitis is a rare condition characterised by endobronchial cast formation. We report the case of a 53-year-old women who deteriorated following an elective bronchoscopy procedure. She developed refractory ventilatory failure and required repeated bronchoscopy, which identified thick tenacious casts as the …

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Lung transplantation for ILD

Henry Yung, J. Parmar

Lung transplantation is the treatment of choice for end-stage lung disease in individuals who have failed maximal therapy. In carefully selected patients it offers both prognostic benefit and an improvement in quality of life. However, it is not a risk-free enterprise and …

Development of a multivariate model to predict clinical deterioration in pulmonary sarcoidosis

Henry Yung, Muhunthan Thillai, Christine A. Fiddler, Nicola Simler et autres

Background: The decision to initiate treatment in pulmonary sarcoidosis is multifactorial and based on clinical acumen, radiological appearance and deterioration in lung function. Aim: To analyse baseline clinical data at time of presentation and develop a prognostic model to predict clinical deterioration. …

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