Multidimensional Statistical Technique for Interpreting the Spontaneous Breakthrough Cancer Pain Phenomenon. A Secondary Analysis from the IOPS-MS Study
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Le résumé fourni par la source
Breakthrough cancer pain (BTcP) is a temporary exacerbation of pain that “breaks through” a phase of adequate pain control by an opioid-based therapy. The non-predictable BTcP (NP-BTcP) is a subtype of BTcP that occurs in the absence of any specific activity. Since NP-BTcP has an important clinical impact, this analysis is aimed at characterizing the NP-BTcP phenomenon through a multidimensional statistical technique. This is a secondary analysis based on the Italian Oncologic Pain multiSetting—Multicentric Survey (IOPS-MS). A correlation analysis was performed to characterize the NP-BTcP profile about its intensity, number of episodes per day, and type. The multiple correspondence analysis (MCA) determined the identification of four groups (phenotypes). A univariate analysis was performed to assess differences between the four phenotypes and selected covariates. The four phenotypes represent the hierarchical classification according to the status of NP-BTcP: from the best (phenotype 1) to the worst (phenotype 4). The univariate analysis found a significant association between the onset time >10 min in the phenotype 1 (37.3%)’ vs. the onset > 10 min in phenotype 4 (25.8%) (p < 0.001). Phenotype 1 was characterized by the gastrointestinal type of cancer (26.4%) with respect to phenotype 4, where the most frequent cancer affected the lung (28.8%) (p < 0.001). Phenotype 4 was mainly managed with rapid-onset opioids, while in phenotype 1, many patients were treated with oral, subcutaneous, or intravenous morphine (56.4% and 44.4%, respectively; p = 0.008). The ability to characterize NP-BTcP can offer enormous benefits for the management of this serious aspect of cancer pain. Although requiring validation, this strategy can provide many indications for identifying the diagnostic and therapeutic gaps in NP-BTcP management.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Multidimensional Statistical Technique for Interpreting the Spontaneous Breakthrough Cancer Pain Phenomenon. A Secondary Analysis from the IOPS-MS Study
- Date Crossref
- 10/08/2021
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" pays non établi dans la noticeÉtablissement de santé
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La Maddalena pays non établi dans la noticeÉtablissement de santé
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Azienda Sanitaria Locale Roma 3 pays non établi dans la noticeOrganisme public
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Sapienza University of Rome Department of Clinical and Molecular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliero-Universitaria Careggi pays non établi dans la noticeÉtablissement de santé
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University of Rome Tor Vergata Department of Clinical Science and Translational Medicine pays non établi dans la noticeUniversité ou école supérieure
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Università Campus Bio-Medico pays non établi dans la noticeUniversité ou école supérieure
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Division of Anesthesia and Pain Medicine pays non établi dans la noticeInstitution
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Epidemiology and Biostatistics Unit pays non établi dans la noticeInstitution
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Melanoma and Sarcoma Surgery Unit pays non établi dans la noticeInstitution
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Anesthesia and Intensive Care & Pain Relief and Supportive Care pays non établi dans la noticeInstitution
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National Cancer Institute Pain Therapy and Rehabilitation pays non établi dans la noticeStructure de recherche
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", La Maddalena et Azienda Sanitaria Locale Roma 3, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.