Gennaro Esposito

Avocado-derived compounds alter lipid homeostasis and lipid droplets profile in Caenorhabditis elegans

Yamanappa Hunashal, Suma Gopinadhan, Raihanah Harion, Fathima S. Refai et autres

Background: Natural compounds from avocado fruit (avocadene, avocadyne, and acetate derivatives) exhibit notable biological activity, although their molecular mechanisms remain unclear. The avocado-derived lipids exert potent nematocidal activity against several parasitic nematodes. In Caenorhabditis elegans (C. elegans), those compounds caused concentration-dependent toxicity, …

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Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Antonella Bonetti, Giovanni Benedetti, Cristina Cantarutti, Veronica Ferrara et autres

Heart transplantation remains the gold standard treatment for end-stage heart failure. To face actual donor shortage, heart warm perfusion with the Organ Care System (OCS) was introduced alternatively to usual cold ischemic storage [1]. Here, OCS-preserved hearts were matched against those subjected …

Manganese-Templated Nontrivial Structures for MRI and Therapy

Farah Benyettou, Thirumurugan Prakasam, Mostafa Khair, Osama Abdullah et autres

High Resolution Image Download MS PowerPoint Slide Manganese (Mn)-based metal–organic architectures offer a unique avenue for integrating magnetic resonance imaging (MRI) and cancer therapy within a single molecular platform. We report three topologically distinct Mn-templated structures─Mn-[2]Catenate (Mn-[2]C), Mn-Trefoil Knot (Mn-TK), and Mn-Borromean …

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Improved pertussis vaccine uptake following in-hospital administration among pregnant women living with HIV

Sara Iannantuoni, Annunziata Carlea, Laura Letizia Mazzarelli, Luigi Falco et autres

BACKGROUND: Pregnant women living with HIV (PWLHIV) are at increased risk of infectious complications during pregnancy, and HIV-exposed but uninfected women are more susceptible to serious infectious diseases. Therefore, maternal immunization during pregnancy is an essential standard of care for this patient …

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Targeting viral replication complexes with mRNA-encoded nanobodies: a new frontier for antiviral design

Jérémy Blavier, Gennaro Esposito, Jean‐Claude Twizere, Piergiorgio Percipalle

Emerging and re-emerging RNA viruses continue to challenge global health preparedness, underscoring the need for broad-spectrum antivirals that can be rapidly deployed. We propose a family-specific antiviral design strategy that targets conserved replication-transcription complexes (RTCs) using nanobodies delivered as mRNA therapeutics. This …

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Assessing Acetyl-Coenzyme A Carboxylase Activity and Inhibition in Caenorhabtidis elegans Using a Partially Purified Protein Extract

Gennaro Battaglia, Yamanappa Hunashal, Suma Gopinadhan, Hin Hark Gan et autres

High Resolution Image Download MS PowerPoint Slide Acetyl-coenzyme A carboxylase (ACC) catalyzes the ATP-dependent carboxylation of acetyl-CoA into malonyl-CoA, the first step in fatty acid biosynthesis. ACC is increasingly recognized as being crucial for energy metabolism, leading to its emergence as a …

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Analytical characterization and biological assay of avocado lipids with nematocidal activity

Yamanappa Hunashal, Fathima Shaffra Refai, Hala Zahreddine Fahs, Kristin C. Gunsalus et autres

To broadly summarize acetogenin characterization based on spectroscopic and chromatographic hallmarks, the water-insoluble acetogenins obtained from Mexico Hass avocado pulp and seed were separated and then purified by HPLC. The components were identified in the water-insoluble fraction of methanolic extracts exploiting the …

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Bluues_cplx: Electrostatics at Protein–Protein and Protein–Ligand Interfaces

Miguel Angel Soler, Rayyan Bassem Adel Yakout, Ozge Ozkilinc, Gennaro Esposito et autres

(1) Background: Electrostatics plays a capital role in protein-protein and protein-ligand interactions. Implicit solvent models are widely used to describe electrostatics and complementarity at interfaces. Electrostatic complementarity at the interface is not trivial, involving surface potentials rather than the charges of surfacial …

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A new class of natural anthelmintics targeting lipid metabolism

Hala Zahreddine Fahs, Fathima Shaffra Refai, Suma Gopinadhan, Hin Hark Gan et autres

Parasitic helminths are a major global health threat, infecting nearly one-fifth of the human population and causing significant losses in livestock and crops. Resistance to the few anthelmintic drugs is increasing. Here, we report a set of avocado fatty alcohols/acetates (AFAs) that …

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Exploiting Natural Fine Chemistry:Extraction and Analysis of Avocado Acetogenins

Gennaro Esposito, Yamanappa Hunashal, Gennaro Batttaglia, Fathima Shaffra Refai et autres

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A new class of natural anthelmintics targeting lipid metabolism

Hala Zahreddine Fahs, Fathima Shaffra Refai, Suma Gopinadhan, Hin Hark Gan et autres

Abstract Parasitic helminths are a major global health threat, infecting nearly one-fifth of the human population and causing significant losses in livestock and crops. Resistance to the few anthelmintic drugs is increasing. Here, we report a set of avocado fatty alcohols/acetates (AFAs) …

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Assessing nanobody interaction with SARS-CoV-2 Nsp9

Gennaro Esposito, Yamanappa Hunashal, Mathias Percipalle, Federico Fogolari et autres

The interaction between SARS-CoV-2 non-structural protein Nsp9 and the nanobody 2NSP90 was investigated by NMR spectroscopy using the paramagnetic perturbation methodology PENELOP (Paramagnetic Equilibrium vs Nonequilibrium magnetization Enhancement or LOss Perturbation). The Nsp9 monomer is an essential component of the replication and …

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