Accès ouvert déclaré 2021 preprint

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium

Lindsay Fernández‐Rhodes, Mariaelisa Graff, Victoria L. Buchanan, Anne E. Justice, Heather M. Highland, Xiuqing Guo, Wanying Zhu, Hung‐Hsin Chen, Kristin L. Young, Kaustubh Adhikari, Nicholette D. Allred, Jennifer E. Below, Jonathan P. Bradfield, Alexandre C. Pereira, LáShauntá Glover, Daeeun Kim, Adam G. Lilly, Poojan Shrestha, Alvin G. Thomas, Xinruo Zhang, Minhui Chen, Charleston W. K. Chiang, Sara L. Pulit, A.R.V.R. Horimoto, José Eduardo Krieger, Marta Guindo-Martínez, Michael Preuß, Claudia Schumann, Roelof A. J. Smit, Gabriela Torres-Mejı́a, Víctor Acuña-Alonzo, Gabriel Bedoya, María Cátira Bortolini, Samuel Canizales‐Quinteros, Carla Gallo, Rolando González‐José, Giovanni Poletti, Francisco Rothhammer, Håkon Håkonarson, Robert P. Igo, Sharon G. Adler, Sudha K. Iyengar, Susanne B. Nicholas, Stephanie M. Gogarten, Carmen R. Isasi, George Papnicolaou, Adrienne M. Stilp, Qibin Qi, Minjung Kho, Jennifer A. Smith, Carl Langfeld, Lynne E. Wagenknecht, Roberta McKean‐Cowdin, Xiaoyi Gao, Darryl Nousome, David V. Conti, Ye Feng, Matthew Allison, Zorayr Arzumanyan, Thomas A. Buchanan, Yii‐Der Ida Chen, Pauline Genter, Mark O. Goodarzi, Yang Hai, Willa A. Hsueh, Eli Ipp, Fouad Kandeel, Kelvin Lam, Xiaohui Li, Jerry L. Nadler, Leslie J. Raffel, Kaye Roll, Kevin Sandow, Jingyi Tan, Kent D. Taylor, Anny H. Xiang, Jie Yao, Astride Audirac-Chalifour, José de Jesús Peralta Romero, Fernando Pires Hartwig, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Donna M. Lehman, Sobha Puppala, Laura Fejerman, Esther M. John, Carlos A. Aguilar‐Salinas, Noël P. Burtt, José C. Florez, Humberto Garcia‐Ortíz, Clicerio González‐Villalpando, Josep M. Mercader, Lorena Orozco, Teresa Tusié, Estela Blanco, Sheila Gahagan, Nancy J. Cox, Craig L. Hanis, Nancy F. Butte, Shelley A. Cole, Anthony G. Commuzzie, V. Saroja Voruganti, Rebecca Rohde, Yujie Wang, Tamar Sofer, Elad Ziv, Struan F.A. Grant, Andrés Ruiz‐Linares, Jerome I. Rotter, Christopher A. Haiman, Esteban J. Parra, Miguel Cruz, Ruth J. F. Loos, Kari E. North

17Citations signalées, ce qui n’est pas une note de qualité

71Institutions déclarées

13Pays d’affiliation déclarés

Rattachement africain : us, gb, br, dk, de, mx, co, pe, ar, cl, fr, cn, ca. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

ABSTRACT Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite notable anthropometric variability with ancestry proportions, and a high burden of growth stunting and overweight/obesity in Hispanic/Latino populations. This address this knowledge gap, we analyzed densely-imputed genetic data in a sample of Hispanic/Latino adults, to identify and fine-map common genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (Stage 1, n=59,769) and validated our findings in 9 additional studies (HISLA Stage 2, n=9,336). We conducted a trans-ethnic GWAS with summary statistics from HISLA Stage 1 and existing consortia of European and African ancestries. In our HISLA Stage 1+2 analyses, we discovered one novel BMI locus, as well two novel BMI signals and another novel height signal, each within established anthropometric loci. In our trans-ethnic meta- analysis, we identified three additional novel BMI loci, one novel height locus, and one novel WHRadjBMI locus. We also identified three secondary signals for BMI, 28 for height, and two for WHRadjBMI. We replicated >60 established anthropometric loci in Hispanic/Latino populations at genome-wide significance—representing up to 30% of previously-reported index SNP anthropometric associations. Trans-ethnic meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our novel findings demonstrate that future studies may also benefit from leveraging differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium
Date Crossref: 29/05/2021
Éditeur: openRxiv
Type: posted-content

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

University of North Carolina at Chapel Hill Pennsylvania State University Neurobehavioral Systems Geisinger Health System University of California, Los Angeles The Lundquist Institute Los Angeles Medical Center Vanderbilt University Medical Center The Open University Wake Forest University Children's Hospital of Philadelphia Universidade de São Paulo University of Southern California Vertex Pharmaceuticals (United Kingdom)University of Copenhagen Novo Nordisk (Denmark)Icahn School of Medicine at Mount Sinai Hasso Plattner Institute University of Potsdam National Institute of Anthropology and History Universidad de Antioquia Universidade Federal do Rio Grande do Sul National Institute of Genomic Medicine Universidad Nacional Autónoma de México Universidad Peruana Cayetano Heredia Centro Científico Tecnológico Patagónico University of Tarapacá Case Western Reserve University University of Washington Albert Einstein College of Medicine National Heart, Lung, and Blood Institute University of Michigan The Ohio State University University of California San Diego Keck Hospital of USC UCLA Medical Center Harbor–UCLA Medical Center Cedars-Sinai Medical Center The Ohio State University Wexner Medical Center City of Hope Beckman Research Institute New York Medical College University of California, Irvine Kaiser Permanente Mexican Social Security Institute Universidade Federal de Pelotas The University of Texas Rio Grande Valley The University of Texas at San Antonio Health Science Center The University of Texas at San Antonio University of California, Davis Stanford University Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Broad Institute Massachusetts Institute of Technology Harvard University Massachusetts General Hospital The University of Texas Health Science Center at Houston Agricultural Research Service United States Department of Agriculture Children's Nutrition Research Center at Baylor College of Medicine Texas Biomedical Research Institute Obesity Society David H. Murdock Research Institute Brigham and Women's Hospital Circadian (United States)University of California, San Francisco UCSF Helen Diller Family Comprehensive Cancer Center Aix-Marseille Université Fudan University University College London University of Toronto

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and Animals

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