Accès ouvert déclaré
2021
article
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
Pradeep Natarajan, Akhil Pampana, Sarah E. Graham, Sanni Ruotsalainen, James A. Perry, Paul S. de Vries, Jai Broome, James P. Pirruccello, Michael C. Honigberg, Krishna G. Aragam, Brooke N. Wolford, Jennifer A. Brody, Lucinda Antonacci-Fulton, Arden Moscati, Stella Aslibekyan, Themistocles L. Assimes, Christie M. Ballantyne, Lawrence F. Bielak, Joshua C. Bis, Brian E. Cade, Ron Do, HarshaVardhan Doddapaneni, Leslie S. Emery, Yi‐Jen Hung, Marguerite R. Irvin, Alyna Khan, Leslie A. Lange, Jiwon Lee, Rozenn N. Lemaître, Lisa W. Martin, Ginger Metcalf, May E. Montasser, Jee‐Young Moon, Donna M. Muzny, Jeffrey R. O’Connell, Juan M. Peralta, Patricia A. Peyser, Adrienne M. Stilp, Michael Y. Tsai, Fei Fei Wang, Daniel E. Weeks, Lisa R. Yanek, James G. Wilson, Gonçalo R. Abecasis, Donna K. Arnett, Lewis C. Becker, John Blangero, Eric Boerwinkle, Donald W. Bowden, Yi‐Cheng Chang, Yii‐Der I. Chen, Won Jung Choi, Adolfo Correa, Joanne E. Curran, Mark J. Daly, Susan K. Dutcher, Patrick T. Ellinor, Myriam Fornage, Barry I. Freedman, Stacey Gabriel, Søren Germer, Richard A. Gibbs, Jiang He, Kristian Hveem, Gail P. Jarvik, Robert C. Kaplan, Sharon L. R. Kardia, Eimear E. Kenny, Ryan W. Kim, Charles Kooperberg, Cathy C. Laurie, Seonwook Lee, Donald M. Lloyd‐Jones, Ruth J. F. Loos, Steven A. Lubitz, Rasika A. Mathias, Karine A. Viaud Martinez, Stephen T. McGarvey, Braxton D. Mitchell, Deborah A. Nickerson, Kari E. North, Cheol Joo Park, Bruce M. Psaty, D. C. Rao, Susan Redline, Alex P. Reiner, Daekwan Seo, Jeong‐Sun Seo, Albert V. Smith, Russell P. Tracy, Ramachandran S. Vasan, Sekar Kathiresan, L. Adrienne Cupples, Jerome I. Rotter, Alanna C. Morrison, Stephen S. Rich, Samuli Ripatti, Cristen J. Willer, Namiko Abe, Christine M. Albert, Laura Almasy, Álvaro Alonso, Seth A. Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum‐Bowden, Dan E. Arking, Allison E. Ashley‐Koch, Paul L. Auer, Dimitrios Avramopoulos, John Barnard, Kathleen C. Barnes, R. Graham Barr, Emily Barron‐Casella, Terri H. Beaty, Diane M. Becker, Rebecca Beer, Ferdouse Begum, Amber L. Beitelshees, Emelia J. Benjamin, Marcos Bezerra, Larry Bielak, Thomas W. Blackwell, Russell P. Bowler, Ulrich Broeckel, Karen Bunting, Esteban G. Burchard, Erin Buth, Jonathan Cardwell, Cara L. Carty, Richard Casaburi, James F. Casella, Mark Chaffin, Christy Chang, Daniel I. Chasman, Sameer Chavan, Bo‐Juen Chen, Wei‐Min Chen, Michael Cho, Seung Hoan Choi, Lee‐Ming Chuang, Mina K. Chung, Matthew P. Conomos, Elaine Cornell, Carolyn Crandall, James D. Crapo, Jeffrey L. Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Sayantan Das, Sean P. David, Colleen Davis, Michelle Daya, Mariza de Andrade, Michael R. DeBaun, Ranjan Deka, Dawn L. DeMeo, Scott E. Devine, Qing Duan, Ravi Duggirala, Jon Peter Durda, Charles B. Eaton, Lynette Ekunwe, Charles R. Farber, Leanna Farnam, Tasha E. Fingerlin, Matthew Flickinger, Nora Franceschini, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Weiniu Gan, Yan Gao, Margery Gass, Bruce D. Gelb, Xiaoqi Geng, Chris Gignoux, Mark T. Gladwin, David C. Glahn, Stephanie M. Gogarten, Da‐Wei Gong, Harald H.H. Göring, C. Charles Gu, Yue Guan, Xiuqing Guo, Jeff Haessler, Michael E. Hall, Daniel Harris, Nicola L. Hawley, Ben Heavner, Susan R. Heckbert, Ryan D. Hernandez, David M. Herrington, Craig P. Hersh, Bertha Hidalgo, James E. Hixson, John E. Hokanson, Elliott Hong, Karin F. Hoth, Chao A. Hsiung, Haley Huston, Chii Min Hwu, Rebecca D. Jackson, Deepti Jain, Cashell E. Jaquish, Min A. Jhun, Jill M. Johnsen, Andrew D. Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Laura J. Kaufman, Shannon Kelly, Michael D. Kessler, Gregory L. Kinney, Barbara A. Konkle, Holly Kramer, Stephanie Krauter, Christoph Lange, Ethan M. Lange, Cecelia Laurie, Meryl S. LeBoff, Seunggeun Shawn Lee, Wen‐Jane Lee, Jonathon LeFaive, David Levine, Daniel Levy, Joshua P. Lewis, Yun Li, Honghuang Lin, Keng Han Lin, Xihong Lin, Simin Liu, Ching‐Ti Liu, Kathryn L. Lunetta, James Luo, Michael C. Mahaney, Barry J. Make, Ani Manichaikul, JoAnn E. Manson, Lauren Margolin, Susan Mathai, Patrick F. McArdle, Merry‐Lynn McDonald, Sean McFarland, Caitlin McHugh, Hao Mei, Deborah A. Meyers, Julie Mikulla, Yuan‐I Min, Mollie Minear, Ryan L. Minster, Solomon K. Musani, Stanford Mwasongwe, Josyf C. Mychaleckyj, Girish N. Nadkarni, Rakhi P. Naik, Take Naseri, Sergeï Nekhai, Sarah C. Nelson, Jeff O’Connell, Tim O’Connor, Heather M. Ochs‐Balcom, James S. Pankow, George Papanicolaou, Margaret M. Parker, Afshin Parsa, Sara Penchev, Marco Perez, Ulrike Peters, Lawrence S. Phillips, Sam Phillips, Toni I. Pollin, Wendy S. Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuß, Dmitry Prokopenko, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Laura M. Raffield, Laura J. Rasmussen‐Torvik, Aakrosh Ratan, Robert M. Reed, Elizabeth A. Regan, Muagututi‘a Sefuiva Reupena, Kenneth Rice, Dan M. Roden, Carolina Roselli, Ingo Ruczinski, Pamela Russell, Sarah Ruuska, Kathleen A. Ryan, Éster Cerdeira Sabino, Phuwanat Sakornsakolpat, Shabnam Salimi, Steven L. Salzberg, Kevin Sandow, Vijay G. Sankaran, Christopher Scheller, Ellen M. Schmidt, Karen Schwander, David Schwartz, Frank C. Sciurba, Christine E. Seidman, Jonathan G. Seidman, Vivien Sheehan, Amol C. Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, M. Benjamin Shoemaker, B. Silver, Edwin K. Silverman, Jennifer A. Smith, J. G. Smith, Nicholas H. Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Tamar Sofer, Nona Sotoodehnia, Elizabeth A. Streeten, Jessica Lasky‐Su, Jody Sylvia, Adam A. Szpiro, Carole Sztalryd, Daniel Taliun, Hua Tang, Margaret A. Taub, Kent D. Taylor, Simeon I. Taylor, Marilyn J. Telen, Timothy A. Thornton, Lesley Tinker, David Tirschwell, Hemant K. Tiwari, Dhananjay Vaidya, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert B. Wallace, Avram Walts, Emily S. Wan, Heming Wang, Karol E. Watson, Bruce S. Weir, Scott T. Weiss, Lu‐Chen Weng, Kayleen Williams, L. Keoki Williams, Carla Wilson, Quenna Wong, Huichun Xu, Ivana V. Yang, Rongze Yang, Norann A. Zaghloul, Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Degui Zhi, Xiang Zhou, Xiaofeng Zhu, Michael C. Zody, Sebastian Zoellner, Howard J. Jacob, Athena Matakidou, Heiko Runz, Sally John, Robert M. Plenge, Mark I. McCarthy, Julie Hunkapiller, Meg Ehm, Dawn Waterworth, Caroline S. Fox, Anders Mälarstig, Kathy Klinger, Kathy Call, Tomi Mkel, Jaakko Kaprio, Petri Virolainen, Kari Pulkki, Terhi Kilpi, Markus Perola, Jukka Partanen, Anne Pitkranta, Riitta Kaarteenaho, Seppo Vainio, Kimmo Savinainen, Veli‐Matti Kosma, Urho M. Kujala, Outi Tuovila, Minna Hendolin, Raimo Pakkanen, Jeff Waring, Bridget Riley‐Gillis, Jimmy Z. Liu, Shameek Biswas, Dorothée Diogo, Catherine Marshall, Xinli Hu, Matthias Gossel, Johanna Schleutker, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Reijo Laaksonen, Juha Paloneva, Hilkka Soininen, Valtteri Julkunen, Anne M. Remes, Reetta Klviinen, Mikko Hiltunen, Jukka Peltola, Pentti Tienari, Juha O. Rinne, Adam Ziemann, Jeffrey F. Waring, Sahar Esmaeeli, Nizar Smaoui, Anne Lehtonen, Susan Eaton, S. Lahdenper�, John A. Michon, Geoff Kerchner, Natalie Bowers, Edmond Teng, John D. Eicher, Vinay Mehta, Padhraig Gormley, Kari Linden, Christopher D. Whelan, Fanli Xu, David Pulford, Martti Frkkil, Sampsa Pikkarainen, Airi Jussila, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Bob Georgantas, Graham Heap, Fedik Rahimov, Keith Usiskin, Joseph Maranville, Tim Lu, Danny Oh, Kirsi Kalpala, Melissa Miller, Linda McCarthy, Kari K. Eklund, Antti Palomki, Pia Isomki, Laura Piril, Oili Kaipiainen-Seppnen, Johanna Huhtakangas, Apinya Lertratanakul, David A. Close, Marla Hochfeld, Nan Bing, Jorge Esparza Gordillo, Nina Mars, Tarja Laitinen, Margit Pelkonen, Hannu Kankaanranta, Terttu Harju, Steven M. Greenberg, Hubert Chen, Jo Betts, Soumitra Ghosh, Veikko Salomaa, Teemu Niiranen, Markus Juonala, Kaj Metsrinne, Mika Khnen, Juhani Junttila, Markku Laakso, Jussi Pihlajamki, Juha Sinisalo, Marja‐Riitta Taskinen, Jari A. Laukkanen, Ben Challis, Andrew S. Peterson, Audrey Y. Chu, Jaakko Parkkinen, Anthony J. Muslin, Heikki Joensuu, Tuomo J Meretoja, Lauri A. Aaltonen, Annika Auranen, Peeter Karihtala, Saila Kauppila, Pivi Auvinen, Klaus Elenius, Relja Popovic, Jennifer L. Schutzman, Andrey Loboda, Aparna Chhibber, Heli Lehtonen, Stefan McDonough, Marika Crohns, Diptee Kulkarni, Kai Kaarniranta, Joni A. Turunen, Terhi Ollila, Sanna Seitsonen, Hannu Uusitalo, Vesa Aaltonen, Hannele Uusitalo-Jrvinen, Marja Luodonp, Nina Hautala, Erich C. Strauss, Hao Chen, Anna Podgornaia, Joshua Hoffman, Kaisa Tasanen, Laura Huilaja, Katariina Hannula‐Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, Ilkka T. Harvima, Ying Wu, David F. Choy, Anu Jalanko, Risto Kajanne, Ulrike Lyhs, Mari Kaunisto, J. Wade Davis, Danjuma Quarless, Slav Petrovski, Chia‐Yen Chen, Paola G. Bronson, Robert Yang, Diana Chang, Tushar Bhangale, Emily Holzinger, Xulong Wang, Xing Chen, sa Hedman, Kirsi Auro, Clarence Wang, Ethan Xu, Franck Augé, Clément Chatelain, Mitja Kurki, Juha Karjalainen, Aki S. Havulinna, Kimmo Palin, Priit Palta, Pietro Della Briotta Parolo, Wei Zhou, Susanna Lemmel, Manuel A. Rivas, Jarmo Harju, Arto Lehistö, Andrea Ganna, Vincent Llorens, Antti Karlsson, Kati Kristiansson, Kati Hyvrinen, Jarmo Ritari, Tiina Wahlfors, Miika Koskinen, Katri Pylks, Marita Kalaoja, Minna K. Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Eija K. Laakkonen, Juha Kononen, Anu Loukola, Pivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Jrvensivu, Sini Lhteenmki, Lotta Mnnikk, Regis Wong, Hannele Mattsson, Tero Hiekkalinna, M. Jim�nez, Kati Donner, Kalle Prn, Javier Núñez-Fontarnau, Elina Kilpelinen, Timo P. Sipil, Georg Brein, Alexander Dada, Awaisa Ghazal, Anastasia Shcherban, Tuomas Sipil, Hannele Laivuori, Tuomo Kiiskinen, Harri Siirtola, Javier Gracia‐Tabuenca, Lila Kallio, Sirpa Soini, Kimmo Pitknen, Teijo Kuopio, Gina M. Peloso
52Citations signalées, ce qui n’est pas une note de qualité
125Institutions déclarées
9Pays d’affiliation déclarés
Rattachement africain : us, fi, tw, no, is, br, ws, gb, fr.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10 −72 ), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls ( P = 1.7 × 10 −4 ), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls ( P = 1.4 × 10 −5 ). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
- Date Crossref
- 12/04/2021
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Broad InstituteHarvard UniversityMassachusetts General HospitalUniversity of MichiganUniversity of HelsinkiFinland UniversityInstitute for Molecular Medicine FinlandUniversity of Maryland, BaltimoreThe University of Texas Health Science Center at HoustonUniversity of WashingtonJames S. McDonnell FoundationWashington University in St. LouisUniversity of Alabama at BirminghamVA Palo Alto Health Care SystemStanford UniversityHouston MethodistBaylor College of MedicineBrigham and Women's HospitalTri-Service General Hospital Songshan BranchUniversity of Colorado AnschutzGeorge Washington UniversityAlbert Einstein College of MedicineWake Forest UniversityThe University of Texas Rio Grande ValleyUniversity of MinnesotaUniversity of PittsburghJohns Hopkins UniversityJohns Hopkins MedicineBeth Israel Deaconess Medical CenterJackson Memorial HospitalUniversity of Mississippi Medical CenterUniversity of KentuckyNational Taiwan University HospitalUCLA Medical CenterHarbor–UCLA Medical CenterNew York Genome CenterTulane UniversityNorwegian University of Science and TechnologyUniversity of Washington Medical CenterFred Hutch Cancer CenterNorthwestern UniversityChild Health and Development InstituteIllumina (United States)Brown UniversityWashington CenterUniversity of North Carolina at Chapel HillKaiser Permanente Washington Health Research InstituteIcelandic Heart AssociationUniversity of VermontBoston UniversityFramingham Heart StudyVerve Therapeutics (United States)University of VirginiaChildren's Hospital of PhiladelphiaUniversity of PennsylvaniaPhiladelphia UniversityEmory UniversityUniversity of MississippiNational Institutes of HealthDuke UniversityUniversity of Wisconsin–MilwaukeeCleveland ClinicUniversity of Colorado DenverColumbia UniversityNational Heart, Lung, and Blood InstituteFundação HemopaNational Jewish HealthMedical College of WisconsinUniversity of California, San FranciscoWomen's Health InitiativeUniversity of California, Los AngelesPacific Research InstituteVitalantVitalant Research InstituteUniversity of Illinois ChicagoUniversity of ChicagoMayo Clinic in FloridaVanderbilt UniversityUniversity of CincinnatiIcahn School of Medicine at Mount SinaiYale UniversityCancer Research CenterAtrium Health Wake Forest BaptistUniversity of IowaBloodworks NorthwestTaichung Veterans General HospitalThe Ohio State University Wexner Medical CenterNorthwest UniversityLoyola University ChicagoBiostats (United States)Harvard University PressUniversity of ArizonaNational University of SamoaHoward UniversityUniversity at Buffalo, State University of New YorkUniversidade de São PauloUMass Memorial Health CareUMass Memorial Medical CenterThe Lundquist InstituteUniversity of Colorado BoulderHenry Ford HealthCase Western Reserve UniversityAbbVie (United States)AstraZeneca (United Kingdom)Biogen (United States)GlaxoSmithKline (United Kingdom)Merck & Co., Inc., Rahway, NJ, USA (United States)Pfizer (United States)Sanofi (France)University of TurkuTurku University HospitalVarsinais-Suomen SairaanhoitopiiriFinnish Institute for Health and WelfareFinnish Red CrossHospital District of Helsinki and UusimaaBorealis (Finland)Northern Ostrobothnia Hospital DistrictUniversity of OuluTampere UniversityPirkanmaa Hospital DistrictTampere UniversityUniversity of Eastern FinlandCentral Finland Health Care DistrictBusiness FinlandTurku Centre for Biotechnology
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Genetic Associations and EpidemiologyLipid metabolism and biosynthesisRNA modifications and cancer