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Accès ouvert déclaré 2021 article

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

52Citations signalées, ce qui n’est pas une note de qualité
125Institutions déclarées
9Pays d’affiliation déclarés

Rattachement africain : us, fi, tw, no, is, br, ws, gb, fr. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Abstract Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European participants. Common alleles on chromosome Xq23 are strongly associated with reduced total cholesterol, LDL cholesterol, and triglycerides (min P = 8.5 × 10 −72 ), with similar effects for males and females. Chromosome Xq23 lipid-lowering alleles are associated with reduced odds for CHD among 42,545 cases and 591,247 controls ( P = 1.7 × 10 −4 ), and reduced odds for diabetes mellitus type 2 among 54,095 cases and 573,885 controls ( P = 1.4 × 10 −5 ). Although we observe an association with increased BMI, waist-to-hip ratio adjusted for BMI is reduced, bioimpedance analyses indicate increased gluteofemoral fat, and abdominal MRI analyses indicate reduced visceral adiposity. Co-localization analyses strongly correlate increased CHRDL1 gene expression, particularly in adipose tissue, with reduced concentrations of blood lipids.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
Date Crossref
12/04/2021
Éditeur
Springer Science and Business Media LLC
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

Broad InstituteHarvard UniversityMassachusetts General HospitalUniversity of MichiganUniversity of HelsinkiFinland UniversityInstitute for Molecular Medicine FinlandUniversity of Maryland, BaltimoreThe University of Texas Health Science Center at HoustonUniversity of WashingtonJames S. McDonnell FoundationWashington University in St. LouisUniversity of Alabama at BirminghamVA Palo Alto Health Care SystemStanford UniversityHouston MethodistBaylor College of MedicineBrigham and Women's HospitalTri-Service General Hospital Songshan BranchUniversity of Colorado AnschutzGeorge Washington UniversityAlbert Einstein College of MedicineWake Forest UniversityThe University of Texas Rio Grande ValleyUniversity of MinnesotaUniversity of PittsburghJohns Hopkins UniversityJohns Hopkins MedicineBeth Israel Deaconess Medical CenterJackson Memorial HospitalUniversity of Mississippi Medical CenterUniversity of KentuckyNational Taiwan University HospitalUCLA Medical CenterHarbor–UCLA Medical CenterNew York Genome CenterTulane UniversityNorwegian University of Science and TechnologyUniversity of Washington Medical CenterFred Hutch Cancer CenterNorthwestern UniversityChild Health and Development InstituteIllumina (United States)Brown UniversityWashington CenterUniversity of North Carolina at Chapel HillKaiser Permanente Washington Health Research InstituteIcelandic Heart AssociationUniversity of VermontBoston UniversityFramingham Heart StudyVerve Therapeutics (United States)University of VirginiaChildren's Hospital of PhiladelphiaUniversity of PennsylvaniaPhiladelphia UniversityEmory UniversityUniversity of MississippiNational Institutes of HealthDuke UniversityUniversity of Wisconsin–MilwaukeeCleveland ClinicUniversity of Colorado DenverColumbia UniversityNational Heart, Lung, and Blood InstituteFundação HemopaNational Jewish HealthMedical College of WisconsinUniversity of California, San FranciscoWomen's Health InitiativeUniversity of California, Los AngelesPacific Research InstituteVitalantVitalant Research InstituteUniversity of Illinois ChicagoUniversity of ChicagoMayo Clinic in FloridaVanderbilt UniversityUniversity of CincinnatiIcahn School of Medicine at Mount SinaiYale UniversityCancer Research CenterAtrium Health Wake Forest BaptistUniversity of IowaBloodworks NorthwestTaichung Veterans General HospitalThe Ohio State University Wexner Medical CenterNorthwest UniversityLoyola University ChicagoBiostats (United States)Harvard University PressUniversity of ArizonaNational University of SamoaHoward UniversityUniversity at Buffalo, State University of New YorkUniversidade de São PauloUMass Memorial Health CareUMass Memorial Medical CenterThe Lundquist InstituteUniversity of Colorado BoulderHenry Ford HealthCase Western Reserve UniversityAbbVie (United States)AstraZeneca (United Kingdom)Biogen (United States)GlaxoSmithKline (United Kingdom)Merck & Co., Inc., Rahway, NJ, USA (United States)Pfizer (United States)Sanofi (France)University of TurkuTurku University HospitalVarsinais-Suomen SairaanhoitopiiriFinnish Institute for Health and WelfareFinnish Red CrossHospital District of Helsinki and UusimaaBorealis (Finland)Northern Ostrobothnia Hospital DistrictUniversity of OuluTampere UniversityPirkanmaa Hospital DistrictTampere UniversityUniversity of Eastern FinlandCentral Finland Health Care DistrictBusiness FinlandTurku Centre for Biotechnology

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Genetic Associations and EpidemiologyLipid metabolism and biosynthesisRNA modifications and cancer

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