Accès ouvert déclaré 2020 article

Comprehensive molecular characterization of mitochondrial genomes in human cancers

Yuan Yuan, Young Seok Ju, Young-Wook Kim, Jun Li, Yumeng Wang, Sung-Soo Yoon, Yang Yang, Iñigo Martincorena, Chad J. Creighton, John N. Weinstein, Yanxun Xu, Leng Han, Hyung‐Lae Kim, Hidewaki Nakagawa, Keunchil Park, Peter J. Campbell, Han Liang, Lauri A. Aaltonen, Federico Abascal, Adam Abeshouse, Hiroyuki Aburatani, David J. Adams, Nishant Agrawal, Keun Soo Ahn, Sung-Min Ahn, Hiroshi Aikata, Rehan Akbani, Kadir Caner Akdemir, Hikmat A Al‐Ahmadie, Sultan T. Al‐Sedairy, Fátima Al‐Shahrour, Malik Alawi, Monique Albert, Kenneth Aldape, Ludmil B. Alexandrov, Adrian Ally, Kathryn Alsop, Eva G. Álvarez, Fernanda M Amary, Samirkumar B. Amin, Brice Aminou, Ole Ammerpohl, Matthew J. J. Anderson, Yeng Shiong Ang, Davide Antonello, Pavana Anur, Samuel A. J. R. Aparicio, Elizabeth L. Appelbaum, Yasuhito Arai, Axel Aretz, Koji Arihiro, Shun‐ichi Ariizumi, Joshua Armenia, Laurent Arnould, Sylvia L. Asa, Yassen Assenov, Gurnit Atwal, Sietse Aukema, J. Todd Auman, Miriam R. R. Aure, Philip Awadalla, Marta Aymerich, Gary D. Bader, Adrian Baez‐Ortega, Peter J. Bailey, Miruna Balasundaram, Saianand Balu, Pratiti Bandopadhayay, Rosamonde Elizabeth Banks, Stefano Barbi, Andrew P. Barbour, Jonathan Barenboim, Jill S. Barnholtz‐Sloan, Hugh Barr, Elisabet Barrera, John A Bartlett, Javier Bartolomé, Claudio Bassi, Oliver F. Bathe, Daniel Baumhoer, Prashant P. Bavi, Stephen B. Baylin, Wojciech Bażant, Duncan Beardsmore, Timothy A. Beck, Sam Behjati, Andreas Behren, Beifang Niu, Cindy Bell, Sergi Beltrán, Christopher C. Benz, Andrew Berchuck, Anke K. Bergmann, Erik N. Bergstrom, Benjamin Paul Berman, Daniel Maurice Berney, Rameen Beroukhim, Mario Berríos, Samantha Bersani, Johanna Bertl, Miguel Betancourt, Vinayak Bhandari, Shriram G. Bhosle, Andrew Victor Biankin, Matthias Bieg, Darell D. Bigner, Hans Binder, Ewan Birney, Michael J. Birrer, Nidhan K. Biswas, Bodil Bjerkehagen, Tom Bodenheimer, Lori Boice, Giada Bonizzato, Johann Sebastian De Bono, Arnoud Boot, Åke Borg, Arndt Borkhardt, Keith A. Boroevich, Ivan Borozan, Christoph W. Borst, Marcus Bosenberg, Mattia Bosio, Jacqueline Boultwood, Guillaume Bourque, Paul Christopher Boutros, G. Steven Bova, David Bowen, Reanne Bowlby, David D.L. Bowtell, Sandrine Boyault, Rich Boyce, Jeffrey M. Boyd, Alvis Brāzma, Paul Martin Brennan, Daniel S. Brewer, Arie B. Brinkman, Robert Glen Bristow, Russell R. Broaddus, Jane E. Brock, Malcolm V. Brock, Annegien Broeks, Angela Norie Brooks, Denise Brooks, Benedikt Brors, Søren Brunak, Timothy J. C. Bruxner, Alicia L. Bruzos, Alex Buchanan, Ivo Buchhalter, Christiane Buchholz, Susan Bullman, Hazel Burke, Birgit Burkhardt, Kathleen H. Burns, John P. Busanovich, Carlos D. Bustamante, Adam P. Butler, Atul Janardhan Butte, Niall J. Byrne, Anne‐Lise Børresen‐Dale, Rory Johnson, Andy Cafferkey, Declan J. Cahill, Claudia Calabrese, Carlos H. Caldas, Fabien M. Calvo, Niedzica Camacho, Elı́as Campo, Cinzia Cantù, Shaolong Cao, Thomas E. Carey, Joana Carlevaro-Fita, Rebecca Birch Carlsen, Ivana Cataldo, Mario Cazzola, Jonathan Simon Cebon, Robert Cerfolio, Dianne E. Chadwick, Dimple Chakravarty, Drc Chalmers, Calvin Wing Yiu Chan, Kin Chan, Michelle Chan Seng Yue, Vishal Suresh Chandan, David Kuang-Fu Chang, Stephen Jacob Chanock, Aurélien Chateigner, Nilanjan Chatterjee, Kazuaki Chayama, Hsiao-Wei Chen, Jieming Chen, Ken Chen, Yiwen Chen, Zhaohong Chen, Andrew D. Cherniack, JEREMY R. CHIEN, Yoke-Eng Chiew, Suet‐Feung Chin, Juok Cho, Sunghoon Cho, Jung Kyoon Choi, Wan Choi, Christine Chomienne, Zechen Chong, Su Pin Choo, Angela S. Y. Chou, Angelika N. Christ, Elizabeth L. Christie, Eric Chuah, Carrie Cibulskis, Kristian Cibulskis, Sara Cingarlini, Peter Clapham, Alexander Claviez, Sean Patrick Cleary, Nicole Cloonan, Marek Cmero, Colin C. Collins, Ashton Anthony Connor, Susanna L. Cooke, Colin S. Cooper, Leslie Cope, Vincenzo Corbo, Matthew G. Cordes, Stephen M. Cordner, Isidro Cortés‐Ciriano, Kyle R. Covington, Prue A. Cowin, Brian Craft, David Craft, Yupeng Cun, Erin E. Curley, Ioana Cutcutache, Karolina M. Czajka, Bogdan A. Czerniak, Rebecca A. Dagg, Ludmila Danilova, Maria Vittoria Davì, Natalie R. Davidson, Helen E. Davies, Ian J. Davis, Brandi N. Davis‐Dusenbery, Kevin J. Dawson, Francisco M. De La Vega, Ricardo De Paoli‐Iseppi, Timothy Defreitas, Angelo Paolo Dei Tos, Olivier Delaneau, John A. Demchok, Jonas Demeulemeester, German M. Demidov, Deniz Demircioğlu, Nening M. Dennis, Robert Edward Denroche, Stefan C. Dentro, Nikita Desai, Vikram Deshpande, Amit G. Deshwar, Christine Desmedt, Jordi Deu-Pons, Noreen Dhalla, Neesha C. Dhani, Priyanka Dhingra, Rajiv Dhir, Anthony DiBiase, Klev Diamanti, Li Jun Ding, Huy Q. Dinh, Luc Yves Dirix, HarshaVardhan Doddapaneni, Nilgun Donmez, Michelle T. Dow, Ronny Drapkin, Oliver Drechsel, Ruben M. Drews, Serge Serge, Tim J. Dudderidge, Ana Dueso-Barroso, Andrew J Dunford, Michael G. Dunn, Lewis Jonathan Dursi, Fraser R. Duthie, Ken Dutton‐Regester, Jenna Eagles, Douglas F. Easton, Stuart D. Edmonds, Paul Alan Edwards, Sandra E. Edwards, Rosalind A. Eeles, Anna Ehinger, Roland Eils, Adel K. El‐Naggar, Matthew Eldridge, Kyle Ellrott, Serap Erkek, Geòrgia Escaramís, Shadrielle M. G. Espiritu, Xavier Estivill, Dariush Etemadmoghadam, Jorunn E. Eyfjord, Bishoy M. Faltas, Daiming Fan, Yu Fan, William C. Faquin, Claudiu Farcas, Matteo Fassan, Aquila Fatima, Francesco Favero, Nodirjon Fayzullaev, Ina Felau, Sián Fereday, Martin L. Ferguson, Vincent Ferretti, Lars Feuerbach, Matthew A. Field, J. Lynn Fink, Gaetano Finocchiaro, Cyril Fisher, Matthew W. Fittall, Anna M. Fitzgerald, Rebecca C. Fitzgerald, Adrienne Margaret Flanagan, Neil Eric Fleshner, Paul Flicek, John A. Foekens, Kwun Meng Fong, Nuno A. Fonseca, Christopher S. Foster, Natalie S. Fox, Michael E. Fraser, Scott Frazer, Milana Frenkel‐Morgenstern, William A. Friedman, Joan Frigola, Catrina C. Fronick, Akihiro Fujimoto, Masashi Fujita, Masashi Fukayama, Lucinda A. Fulton, Robert S. Fulton, Mayuko Furuta, P. Andrew Futreal, Anja Füllgrabe, Stacey L. Gabriel, Steven S. Gallinger, Carlo B Gambacorti-Passerini, Jianjiong Gao, Shengjie Gao, Levi A. Garraway, Øystein Garred, Erik P. Garrison, Dale W. Garsed, Nils Gehlenborg, Josep L. L. Gelpi, Joshy George, Daniela Se Gerhard, Clarissa Gerhäuser, Mark Gerstein, Moritz Gerstung, Gad A. Getz, Mohammed Ghori, Ronald A. Ghossein, Nasra H. Giama, Richard A. Gibbs, Bob Gibson, Anthony James Gill, Pelvender Gill, Dilip D. Giri, Dominik Głodzik, Vincent J. Gnanapragasam, Maria Elisabeth Goebler, Mary J. Goldman, Carmen Elena Gómez, Santiago Gonzalez, Abel González-Pérez, Dmitry A. Gordenin, James Gossage, Kunihito Gotoh, Ramaswamy Govindan, Dorthe Aamand Grabau, Janet Shirley Graham, Robert C. Grant, Anthony Richard Green, Eric P Green, Liliana Greger, Nicola Grehan, Sonia Grimaldi, Sean Michael Grimmond, Robert L. Grossman, Adam T. Grundhoff, Gunes Gundem, Qianyun Guo, Manaswi Gupta, Shailja Gupta, Ivo Glynne Gut, Jonathan Göke, Gavin Ha, Andrea Haake, David Haan, Siegfried Haas, Kerstin Haase, James E. Haber, Faraz Hach, Syed Haider, Natsuko Hama, Freddie Charles Hamdy, Anne L. Hamilton, Mark P. Hamilton, George Bushra Hanna, Martin Leo Hansmann, Nicholas J. Haradhvala, Olivier Harismendy, Ivon Harliwong, Arif O. Harmanci, Eoghan Harrington, Takanori Hasegawa, David H. Haussler, Steve Hawkins, Shinya Hayami, Shuto Hayashi, D. Neil Hayes, Stephen J. Hayes, Nicholas K. Hayward, Steven Hazell, Yao He, Allison P. Heath, Simon Charles Heath, David William Hedley, Apurva M. Hegde, David I. Heiman, Michael C. Heinold, Zachary J. Heins, Lawrence E. Heisler, Eva Hellstrom-Lindberg, Mohamed Ahmed Helmy, Seong Gu Heo, Austin J. Hepperla, José María Heredia‐Genestar, Carl Herrmann, Peter Hersey, Julian M. Hess, Hólmfríður Hilmarsdóttir, Jonathan Hinton, Satoshi Hirano, Nobuyoshi Hiraoka, Katherine A. Hoadley, Asger Hobolth, Ermin Hodzic, Jessica I. Hoell, Steve Hoffmann, Oliver Hofmann, Andrea Holbrook, Aliaksei Z. Holik, Michael Anthony Hollingsworth, Oliver Holmes, Robert A. Holt, Chen Hong, Eun Pyo Hong, Jongwhi H. Hong, Gerrit K. J. Hooijer, Henrik Hornshøj, Fumie Hosoda, Yong Hou, Volker Hovestadt, William Howat, Alan P. Hoyle, Ralph H. Hruban, Taobo Hu, Xing Hua, Kuan‐lin Huang, Mei Huang, Mi Ni Huang, Vincent J. Huang, Yi Fei Huang, Wolfgang K. Huber, Thomas Jay Hudson, Michael Hummel, Jillian A. Hung, David George Huntsman, Ted R. Hupp, Jason T. Huse, Matthew R. Huska, Barbara Hutter, Carolyn M. Hutter, Daniel Hübschmann, Christine A. Iacobuzio–Donahue, Charles David Imbusch, Marcin B. Imielinski, Seiya Imoto, William B. Isaacs, Keren Isaev, Shumpei Ishikawa, Murat Iskar, S. M. Ashiqul Islam, Michael Ittmann, Sinisa Ivkovic, José M. G. Izarzugaza, Jocelyne Jacquemier, Valerie Jakrot, Nigel Balfour Jamieson, Gun Ho Jang, Se Jin Jang, Joy C. Jayaseelan, Reyka G. Jayasinghe, Karine Jegalian, Jennifer L. Jennings, Seung-Hyup Jeon, Lara Jerman, Yuan Ji, Wei Jiao, Peter A. Johansson, Amber L. Johns, Jeremy Johns, Todd A. Johnson, Clemency Jolly, Yann Joly, Jon Gunnlaugur Jonasson, Corbin D. Jones, David Jones, Nic Jones, Steven J.M. Jones, Jos Jonkers, Hartmut H. Juhl, Jongsun Jung, Malene Juul, Randi Istrup Juul, Natalie Jäger, Rolf Kabbe, André Kahles, Abdullah Kahraman, Vera B. Kaiser, Hojabr Kakavand, Sangeetha N. Kalimuthu, Christof V. Kalle, Koo Jeong Kang, Katalin Karászi, Beth Y. Karlan, Rosa Karlić, Dennis Karsch, Karin S. Kassahn, Hitoshi Katai, Mamoru Kato, Hiroto Katoh, Yoshiiku Kawakami, Jonathan D.S. Kay, Stephen H. Kazakoff, Marat D. Kazanov, Maria Keays, Electron Kebebew, Richard F. Kefford, Manolis Kellis, James G. Kench, Catherine J. Kennedy, Jules N. A. Kerssemakers, David Khoo, Vincent S Khoo, Narong Khuntikeo, Ekta Khurana, Helena Kilpinen, Hark Kyun Kim, Hyung-Yong Kim, Hyunghwan Kim, Ji-Hoon Kim, Jong K. Kim, Tari A. King, Kortine Kleinheinz, Leszek J. Klimczak, Stian Knappskog, Michael Kneba, Bartha Maria Knoppers, Youngil Koh, Jan Komorowski, Daisuke Komura, Mitsuhiro Komura, Gu Kong, Marcel Kool, Jan O. Korbel, Viktoriya Korchina, Andrey Korshunov, Michael Koscher, Roelof Koster, Zsofia Kote‐Jarai, Antonios Koures, Milena Kovačević, Bárbara Kremeyer, Helene Kretzmer, Markus Kreuz, Savitri Krishnamurthy, Dieter Kube, Kiran Kumar, Pardeep Kumar, Sushant Kumar, Yogesh Kumar, Ritika Kundra, Kirsten Kübler, Ralf Küppers, Jesper Lagergren, Phillip H. Lai, Peter W. Laird, Sunil R. Lakhani, Christopher M. Lalansingh, Emilie Lalonde, Fabien Claude Lamaze, Adam G. Lambert, Eric Lander, Pablo Landgraf, Luca Landoni, Anita Langerød, Andrés Lanzós, Denis Larsimont, Erik Larsson, Mark Lathrop, Loretta M. S. Lau, Chris Lawerenz, Rita Teresa Lawlor, Michael S. Lawrence, Alexander J. Lazar, Ana Mijalkovic Lazic, Xuan Le, Darlene Lee, Donghoon Lee, Eunjung Alice Lee, Hee Jin Lee, Jake June-Koo Lee, Jeong‐Yeon Lee, Ju Hee Lee, Ming Ta Michael Lee, Henry Lee-Six, Kjong-Van Lehmann, Hans Lehrach, Dido Lenze, Conrad Leonard, Daniel A. Leongamornlert, Ignaty Leshchiner, Louis Létourneau, Ivica Letunić, Douglas A. Levine, Lora R Lewis, Tim Ley, Chang Li, Constance H. Li, Haiyan Irene Li, Lin Li, Shantao Li, Siliang Li, Xiaobo Li, Xiaotong Li, Xinyue Li, Yilong Li, Sheng‐Ben Liang, Peter Lichter, Pei Yi Lin, Ziao Lin, W. Marston Linehan, Ole Christian Lingjærde, Dongbing Liu, Eric Minwei Liu, Fei-Fei Fei Liu, Fenglin Liu, Jia Liu, Xingmin Liu, Julie M. Livingstone, Dimitri G. Livitz, Naomi Livni, Lucas Lochovsky, Markus W. Loeffler, Georgina Venetia Long, Armando López‐Guillermo, Shaoke Lou, David N. Louis, Laurence B. Lovat, Yiling Lu, Yong‐Jie Lu, Youyong Lu, Claudio Luchini, Ilinca M. Lungu, Xuemei Luo, Hayley J. Luxton, Andy G. Lynch, Lisa Lype, Cristina Gonzalez Lopez, Carlos López-Otı́n, Eric Z. Ma, Yussanne Ma, Gaëtan Marie MacGrogan, Shona MacRae, Geoff Macintyre, Tobias Lynge Madsen, Kazuhiro Maejima, Andrea Mafficini, Dennis T. Maglinte, Arindam Maitra, Partha P. Majumder, Luca Malcovati, Salem Malikić, Giuseppe Malleo, Graham J. Mann, Luisa Mantovani‐Löffler, Kathleen Marchal, Giovanni Marchegiani, Elaine R. Mardis, Maximillian G. Marin, Florian Markowetz, Julia Markowski, Jeffrey S. Marks, Tomàs Marquès‐Bonet, Marco A. Marra, Luke Marsden, John W.M. Martens, Sancha Martin, José Ignacio Martín-Subero, Alexander Martinez‐Fundichely, Yosef E. Maruvka, R. Jay Mashl, Charles E. Massie, Thomas J. Matthew, Lucy Matthews, Erik Mayer, Simon Mayes, Michael L. Mayo, Faridah Mbabaali, Karen Smith McCune, Ultan McDermott, Patrick D. McGillivray, Michael D. McLellan, John D. McPherson, John R. McPherson, Treasa A. McPherson, Samuel R. Meier, Alice Meng, Shaowu Meng, Andrew H. Menzies, Neil Donald Merrett, Sue Merson, Matthew Meyerson, William Meyerson, Piotr A. Mieczkowski, George L. Mihaiescu, Sanja Mijalković, Tom Mikkelsen, Michèle Milella, Linda Mileshkin, Christopher A. Miller, David K. Miller, Jessica K. Miller, Gordon Brent Mills, Ana Milovanovic, Sarah Jane Pauline Minner, Marco Miotto, Gisela Mir Arnau, Lisa Mirabello, Thomas J. Mitchell, Satoru Miyano, Naoki Miyoshi, Shinichi Mizuno, Fruzsina Molnár-Gábor, Malcolm J. Moore, Richard A. Moore, Sandro Morganella, Quaid Morris, Carl D. Morrison, Lisle E. Mose, Catherine D. Moser, Ferran Muiños, Loris Mularoni, Andrew J. J. Mungall, Karen L. Mungall, Elizabeth A. Musgrove, Ville Mustonen, David G. Mutch, Francesc Muyas, Donna Marie Muzny, Alfonso Muñoz, Jerome Myers, Ola Myklebost, Peter Möller, Genta Nagae, Adnan M. Nagrial, Hardeep K. Nahal-Bose, Hitoshi Nakagama, Hiromi K. Nakamura, Tõru Nakamura, Kaoru Nakano, Tannistha Nandi, Jyoti Nangalia, Mia Nastic, Arcadi Navarro, Fábio C. P. Navarro, David E. Neal, Gerd Nettekoven, Felicity Newell, Steven J. Newhouse, Yulia Newton, Alvin Wei Tian Ng, Chi‐Fai Ng, Jonathan Nicholson, David M. Nicol, Yongzhan Nie, G. Petur Nielsen, Morten Muhlig Nielsen, Serena Nik‐Zainal, Michael S. Noble, Kátia Nones, Paul A. Northcott, Faiyaz Notta, Brian D. O’Connor, Peter H. O’Donnell, Maria O’Donovan, Sarah O’Meara, Brian Patrick O’Neill, J. Robert O’Neill, David Ocaña, Angelica Ochoa, Layla Oesper, Christopher W. Ogden, Hideki Ohdan, Kazuhiro Ohi, Lucila Ohno‐Machado, Karin A. Oien, Akinyemi I. Ojesina, Hidenori Ojima, Takuji Okusaka, Larsson Omberg, Choon Kiat Ong, Stephan Ossowski, German Ott, B. F. Francis Ouellette, Christine P’ng, Marta Paczkowska, Salvatore Paiella, Chawalit Pairojkul, Marina Pajic, Qiang Pan‐Hammarström, Elli Papaemmanuil, Irene Papatheodorou, Nagarajan Paramasivam, Ji Wan Park, Joong‐Won Park, Kiejung Park, Peter J. Park, Joel S. Parker, Simon L. Parsons, Harvey Ira Pass, Danielle Pasternack, Alessandro Pastore, Ann‐Marie Patch, Iris Pauporté, Antonio Pea, John V. Pearson, Chandra Sekhar Pedamallu, Jakob Skou Pedersen, Paolo Pederzoli, Martin Peifer, Nathan A. Pennell, Charles M. Perou, Marc D. Perry, Gloria M. Petersen, Myron Peto, Nicholas Petrelli, Robert Petryszak, Stefan M. Pfister, Mark Edward Phillips, Oriol Pich, Hilda A. Pickett, Todd Pihl, Nischalan Pillay, Sarah Pinder, Mark Pinese, Andreia V. Pinho, Esa Pitkänen, Xavier Pivot, Elena Piñeiro-Yáñez, Laura Planko, Christoph Plass, Paz P Polak, Tirso Pons, Irinel Popescu, Olga Potapova, Aparna Prasad, Shaun R. Preston, Manuel Prinz, Antonia L. Pritchard, Stephenie D. Prokopec, Elena Provenzano, Xosé S. Puente, Montserrat Puiggròs, Sergio Pulido-Tamayo, Gulietta M. Pupo, Colin A. Purdie, Michael C. J. Quinn, Raquel Rabionet, Janet Sue Rader, Bernhard Radlwimmer, Petar Radovic, Benjamin Raeder, Keiran M. Raine, Manasa Ramakrishna, Kamna Ramakrishnan, Suresh Ramalingam, Benjamin J. Raphael, W. Kimryn Rathmell, Tobias Rausch, Guido Reifenberger, Jüri Reimand, Jorge Sergio Reis-Filho, Victor Reuter, Iker Reyes-Salazar, Matthew A. Reyna, Sheila M. Reynolds, Esther Rheinbay, Yasser Riazalhosseini, Andrea L. Richardson, Julia Richter, Matthew David Ringel, Markus Ringnér, Yasushi Rino, Karsten Rippe, Jeffrey M. Roach, Lewis Rowland Roberts, Nicola D. Roberts, Steven A. Roberts, A. Gordon Robertson, Alan J. Robertson, Javier Bartolomé Rodriguez, Bernardo Rodríguez–Martín, Francisco Germán Rodríguez-González, Michael H. A. Roehrl, Marius Rohde, Hirofumi Rokutan, Gilles Romieu, Ilse Rooman, Tom W. Roques, Daniel Rosebrock, Mara W. Rosenberg, Philip C Rosenstiel, Andreas Rosenwald, Edward Rowe, Romina Royo, Steven G. Rozen, Yulia Rubanova, Mark Andrew Rubin, Carlota Rubio-Pérez, Vasilisa A. Rudneva, Borislav Chavdarov Rusev, Andrea Ruzzenente, Gunnar Rätsch, Radhakrishnan Sabarinathan, Veronica Y. Sabelnykova, Sara Sadeghi, S. Cenk Sahinalp, Natalie Saini, Mihoko Saito-Adachi, Gordon Saksena, Adriana Salcedo, Roberto Salgado, Leonidas Salichos, Richard C. Sallari, Charles F. Saller, Roberto Salvia, Michelle Sam, Jaswinder Singh Samra, Francisco Sánchez-Vega, Chris Sander, Grant Sanders, Rajiv Sarin, Iman Sarrafi, Aya Sasaki-Oku, Torill Sauer, Guido Sauter, Robyn P.M. Saw, Maria Scardoni, Christopher James Scarlett, Aldo Scarpa, Ghislaine Scélo, Dirk Schadendorf, Jacqueline E. Schein, Markus B. Schilhabel, Matthias Schlesner, Thorsten Schlomm, Heather K. Schmidt, Sarah‐Jane Schramm, Stefan Schreiber, Nikolaus D. Schultz, Steven E. Schumacher, Roland F. Schwarz, Richard A. Scolyer, David W. Scott, Ralph Scully, Raja Seethala, Ayellet V. Segrè, Iris Selander, Colin A M Semple, Yasin Şenbabaoğlu, Subhajit Sengupta, Elisabetta Sereni, Stefano Serra, Dennis C. Sgroi, Mark J. Shackleton, Nimish C Shah, Sagedeh Shahabi, Catherine A. Shang, Ping Shang, Ofer Shapira, Troy Shelton, Ciyue Shen, Hui Shen, Rebecca F. Shepherd, Ruian Shi, Yan Shi, Yu-Jia Shiah, Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu, Kiyo Shimizu, Seung Jun Shin, Yuichi Shiraishi, Tal Shmaya, Ilya Shmulevich, Solomon I. Shorser, Charles L. Short, Raunak Shrestha, Suyash Shringarpure, Craig D. Shriver, Shimin Shuai, Nikos Sidiropoulos, Reiner Siebert, Anieta M. Sieuwerts, Lina Sieverling, Sabina Signoretti, Katarzyna O. Sikora, Michele Simbolo, Ronald Simon, Janae V. Simons, Jared T. Simpson, Peter T. Simpson, Samuel Singer, Nasa Sinnott-Armstrong, Payal Sipahimalani, Tara J. Skelly, Marcel Smid, Jaclyn Smith, Karen Smith‐McCune, Nicholas D. Socci, Heidi J. Sofia, Matthew G. Soloway, Lei Song, Anil K. Sood, Sharmila Sothi, Christos P. Sotiriou, Cameron M. Soulette, Paul N. Span, Paul T. Spellman, Nicola Sperandio, Andrew John Spillane, Oliver G. Spiro, Jonathan Spring, Johan Staaf, Peter Florian Stadler, Peter Staib, Stefan G. Stark, Lucy A. Stebbings, Ólafur Andri Stefánsson, Oliver Stegle, Lincoln Stein, Alasdair Stenhouse, Chip Stewart, Stephan Stilgenbauer, Miranda D. Stobbe, Michael R. Stratton, Jonathan R. Stretch, Adam J. Struck, Joshua M. Stuart, Henk G. Stunnenberg, Hong Lin Su, Xiaoping Su, Ren Sun, Stéphanie Sungalee, Hana Sušak, Akihiro Suzuki, Fred C.G.J. Sweep, Monika Szczepanowski, Holger Sültmann, Takashi Yugawa, Angela Tam, David Tamborero, Benita Kiat Tee Tan, Donghui Tan, Patrick Tan, Hiroko Tanaka, Hirokazu Taniguchi, Tomas J. Tanskanen, Maxime Tarabichi, Roy W Tarnuzzer, Patrick S. Tarpey, Morgan L. Taschuk, Kenji Tatsuno, Simon Tavaré, Darrin F. Taylor, Amaro N Taylor-Weiner, Jon W. Teague, Bin Tean Teh, Varsha Tembe, Javier Temes, Kevin Eric Thai, Sarah P. Thayer, Nina Thiessen, Gilles Thomas, Sarah K. Thomas, Alan Thompson, Alastair Mark Thompson, John F. Thompson, R. Houston Thompson, Heather Thorne, Leigh B. Thorne, Adrian Thorogood, Grace Tiao, Nebojša Tijanić, Lee E. Timms, Roberto Tirabosco, Marta Tojo, Stefania Tommasi, Christopher W. Toon, Umut H. Toprak, David Torrents, Giampaolo Tortora, Jörg Tost, Yasushi Totoki, David M. R. Townend, Nadia Traficante, Isabelle Treilleux, Jean-Rémi Trotta, Lorenz H. P. Trümper, Ming‐Sound Tsao, Tatsuhiko Tsunoda, José M. C. Tubío, Olga Tucker, Richard Calvin Turkington, Daniel J. Turner, Andrew N.J. Tutt, Masaki Ueno, Naoto Tada Ueno, Christopher B. Umbricht, Husen Muhammad Umer, Tim Underwood, Lara Urban, Tomoko Urushidate, Tetsuo Ushiku, Liis Uusküla-Reimand, Alfonso Valencia, David Van Den Berg, Steven Van Laere, Peter Van Loo, Erwin G. Van Meir, Gert G. Van den Eynden, Theodorus van der Kwast, Naveen S. Vasudev, Miguel Vazquez, Ravikiran Vedururu, Umadevi Veluvolu, Shankar Vembu, Peter B. Vermeulen, Clare L. Verrill, Alain Viari, David Vicente, Caterina Vicentini, K. VijayRaghavan, Juris Vīksna, Ricardo E. Vilain, Izar Villasante, Anne Vincent‐Salomon, Tapio Visakorpi, Douglas Voet, Paresh Vyas, Ignacio Vázquez-Garćıa, Nick M. Waddell, Nicola Waddell, Claes Wadelius, Lina Wadi, Rabea Wagener, Jeremiah A. Wala, Jian Wang, Jiayin Wang, Linghua Wang, Qi Wang, Wenyi Wang, Paul Waring, Hans-Jörg Warnatz, Jonathan Warrell, Anne Yvonne Warren, Sebastian M. Waszak, David C. Wedge, Dieter Weichenhan, Paul Weinberger, Joachim Lütken Weischenfeldt, Daniel J. Weisenberger, Ian Welch, Michael C. Wendl, Johannes Werner, Justin P. Whalley, David A. Wheeler, Hayley C. Whitaker, Dennis A. Wigle, Matthew D. Wilkerson, Ashley A. Williams, James S. Wilmott, Gavin W. Wilson, Julie M. Wilson, Richard K. Wilson, Boris J. N. Winterhoff, Jeffrey A. Wintersinger, Maciej Wiznerowicz, Stephan Wolf, Bernice Huimin Wong, Tina Wong, Winghing Wong, Youngchoon Woo, Scott Wood, Bradly G. Wouters, A. Jordan Wright, Derek Wright, Mark H. Wright, Chin‐Lee Wu, Dai‐Ying Wu, Guanming Wu, Jianmin Wu, Kui Wu, Yang Wu, Zhenggang Wu, Xi Liu, Tian Xia, Qian Xiang, Xiao Xiao, Rui Xing, Heng Xiong, Qinying Xu, Hong Xue, Shinichi Yachida, Sergei Yakneen, Takafumi N. Yamaguchi, Masakazu Yamamoto, Shogo Yamamoto, Hiroki Yamaue, Fan Yang, Huanming Yang, Jean Yee Hwa Yang, Liming Yang, Lixing Yang, Shanlin Yang, Tsun-Po Yang, Xiaotong Yao, Marie‐Laure Yaspo, Lucy R. Yates, Christina S. F. Yau, Chen Ye, Kai Ye, Venkata D. Yellapantula, Fouad Yousif, Jun Yu, Kaixian Yu, Willie Yu, Yingyan Yu, Ke Yuan, Denis Yuen, Christina K. Yung, Olga Zaikova, Jorge Zamora, Marc Zapatka, Jean Claude Zenklusen, Thorsten Zenz, Nikolajs Zeps, Cheng‐Zhong Zhang, Fan Zhang, Hailei Zhang, Hongwei Zhang, Hongxin Zhang, Jiashan Zhang, Jing Zhang, Junjun Zhang, Xiuqing Zhang, Xuanping Zhang, Yan Zhang, Zemin Zhang, Zhongming Zhao, Liangtao Zheng, Xiuqing Zheng, Wanding Zhou, Yong Hong Zhou, Bin Zhu, Hongtu Zhu, Jingchun Zhu, Shida Zhu, Lihua Zou, Xueqing Zou, Anna DeFazio, Nicholas J. van As, Carolien H. M. van Deurzen, Marc J. van de Vijver, L. van’t Veer, Christian von Mering

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Rattachement africain : us, kr, gb, jp. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we performed a multidimensional, integrated characterization of mitochondrial genomes and related RNA sequencing data. Our analysis presents the most definitive mutational landscape of mitochondrial genomes and identifies several hypermutated cases. Truncating mutations are markedly enriched in kidney, colorectal and thyroid cancers, suggesting oncogenic effects with the activation of signaling pathways. We find frequent somatic nuclear transfers of mitochondrial DNA, some of which disrupt therapeutic target genes. Mitochondrial copy number varies greatly within and across cancers and correlates with clinical variables. Co-expression analysis highlights the function of mitochondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connections with clinically actionable genes. Our study lays a foundation for translating mitochondrial biology into clinical applications.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Comprehensive molecular characterization of mitochondrial genomes in human cancers
Date Crossref: 05/02/2020
Éditeur: Springer Science and Business Media LLC
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

The University of Texas MD Anderson Cancer Center Department of Bioinformatics and Computational Biology pays non établi dans la notice
Établissement de santé
Korea Advanced Institute of Science and Technology pays non établi dans la notice
Université ou école supérieure
Wellcome Sanger Institute pays non établi dans la notice
Organisation à but non lucratif
Samsung (South Korea) pays non établi dans la notice
Entreprise
Samsung Medical Center pays non établi dans la notice
Établissement de santé
Sungkyunkwan University Department of Health Science and Technology pays non établi dans la notice
Université ou école supérieure
Baylor College of Medicine Quantitative and Computational Biosciences Graduate Program pays non établi dans la notice
Université ou école supérieure
Quantitative BioSciences pays non établi dans la notice
Organisation à but non lucratif
The University of Texas Health Science Center at Houston Division of Biostatistics pays non établi dans la notice
Université ou école supérieure
Johns Hopkins University Department of Applied Mathematics and Statistics pays non établi dans la notice
Université ou école supérieure
Ewha Womans University Department of Biochemistry pays non établi dans la notice
Université ou école supérieure
RIKEN Center for Integrative Medical Sciences pays non établi dans la notice
Structure de recherche

Department of Bioinformatics and Computational Biology — The University of Texas MD Anderson Cancer Center, Korea Advanced Institute of Science and Technology et Wellcome Sanger Institute, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Cancer Genomics and DiagnosticsRNA modifications and cancerMitochondrial Function and Pathology

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