Accès ouvert déclaré 2019 article

Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial

Bastian Cheng, Florent Boutitie, Alina Nickel, Anke Wouters, Tae‐Hee Cho, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Ivana Galinović, Josep Puig, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Christian P Gerloff, Götz Thomalla, Amir Golsari, Anna Christina Alegiani, Christoph Beck, Chi‐un Choe, Dieke Voget, Julia Hoppe, Julian Schröder, Michał Różański, Alexander H. Nave, Christian Wollboldt, Isabelle van Sloten, Jos Göhler, Juliane Herm, Jan Jungehülsing, János Lückl, Jan Kröber, Johannes Schurig, Luzie Koehler, Ludwig Schlemm, Michael Knops, Maria Roennefarth, Nils Ipsen, Peter Harmel, Rouven Bathe-Peters, Robert D Fleischmann, Ramanan Ganeshan, Rohat Geran, Simon Hellwig, Sein H. Schmidt, Serdar Tütüncü, Thomas Krause, Verena Gramse, Joachim A. Rother, Peter Michels, Dominik Michalski, Johann Otto Pelz, Andreas Schulz, Carsten Hobohm, Christopher M. Weise, Gesa Weise, Johannes Orthgieß, Katrin Pomrehn, Mirko Wegscheider, Anne K. Mueller, Michael G. Hennerici, Martin Griebe, Angelika Alonso, Alexandra Filipov, Annika Marzina, Bettina Anders, Christian Bähr, Carolin Hoyer, Christopher Jan Schwarzbach, Claudia E.M. Weber, Eva Hornberger, Hans-Werner Pledl, Matti Klockziem, Markus Stuermlinger, Matthias Wittayer, Marc E. Wolf, Nadja Meyer, Philipp Eisele, Susanne Steinert, Tamara Sauer, Valentin Held, Peter Arthur Ringleb, Simon Nagel, Roland C. Veltkamp, Sönke Schwarting, Alexander Pavlovich Schwarz, Christoph Gumbinger, Christian Hametner, Hemasse Amiri, Jan Christoph Purrucker, Mareva Ciatipis, Oliver Menn, Sibu Mundiyanapurath, Simon Schieber, Tobias Keßler, Tilman Reiff, Verena Panitz, Oliver C. Singer, Christian Foerch, Arne Lauer, Anika Männer, Alexander Seiler, Damla Guerzoglu, Jan Hendrik Schäfer, Katharina Filipski, Matthias Lorenz, Natalia Kurka, Pia Susann Zeiner, Waltraud Pfeilschifter, Rainer Dziewas, Jens Minnerup, Christian Albiker, Martin Ritter, Matthias F. Seidel, Ralf Dittrich, Bernd Kallmünzer, Tobias Bobinger, Dominik Madžar, David Stark, Jochen A. Sembill, Kosmas Macha, Klemens Winder, Lorenz Breuer, Martin Koehrmann, Maximilian Spruegel, Stefan T. Gerner, Peter Kraft, Daniel Mackenrodt, Christoph Kleinschnitz, Ahmed Mohamed Elhfnawy, Florian Heinen, Ignaz Gunreben, Sven Poli, Ulf Ziemann, Alexandra Gaenslen, Dennis Schlak, Florian Haertig, Francesca Maria Russo, Hardy Richter, Matthias Ebner, Martin Ribitsch, Martin Wolf, Christian Weimar, Vesna Zegarac, Hsin-Chieh Chen, Katharina Althaus, Hermann Neugebauer, Eric Jüttler, Julia C. Meier, Sebastian Stösser, Volker Puetz, Ulf Bodechtel, Leif Østergaard, A.H. Møller, Dorte Damgaard, Kristina Hougaard Dupont, Marika Suzuki Poulsen, Niels Hjort, Noelia Ruiz de Morales, Paul von Weitzel, Thomas Harbo, Jacob Rørbech Marstrand, Andreas Hansen, Hanne Christensen, Karen Lehrmann Ægidius, Lise Leth Jeppesen, Per Meden, Sverre Rosenbaum, Helle Klingenberg Iversen, Jakob Møller Hansen, Lene Michelsen, Thomas Clement Truelsen, Boris Modrau, Karsten Vestergaard, Lorenz Oppel, Aalborg Sygehus, Syd Aalborg, Bart Swinnen, Ide Smets, Jelle Demeestere, Laurens Dobbels, Raf Brouns, Ann De Smedt, Jacques De Keyser, Laetita Yperzeele, R.-J. Van Hooff, Andre Philippe Peeters, Anne Dusart, Ana Etexberria, Bernard Jimmy Hanseeuw, Frédéric London, Jonathan Leempoel, Katharina Hohenbichler, Nadia Younan, Vicky Maqueda, Patrice Laloux, Beatrijs De Coene, Charlotte De Maeseneire, Gaëtane Turine, Yves Vandermeeren, Nina De Klippel, Chris Willems, Isabel de Hollander, Peter Soors, Sylvia Hermans, Dimitri Hemelsoet, Philippe Desfontaines, Peter Vanacker, Matthieu Pierre Rutgers, Charlotte Druart, Dirk Peeters, Bart Bruneel, Evelien Vancaester, Frederik Vanhee, Guy Meersman, Paul Bourgeois, Patrick Vanderdonckt, Amandine Benoit, Laurent Derex, Laura Mechthouff, Nadia Berhoune, Thomas Ritzenthaler, Pierre Amarenco, Cristina Hobeanu, D. Calvet, Alexandre Ladoux, Alexandre Machet, Catherine Lamy, Charles Mellerio, Catherine Oppenheim, Christine Rodriguez-Régent, Eric Bodiguel, Guillaume Turc, Julia Birchenall, Laurence Legrand, Ludovic Morin, Myriam Edjali-Goujon, Oliver Naggara, Soulliard Raphaelle, Sylvie Godon-Hardy, Valérie Domigo, Vincent Guiraud, Yves Samson, Anne Léger, Charlotte Rosso, Flore Baronnet-Chauvet, Sophie Crozier, S. Deltour, Marion Yger, Igor Sibon, Pauline Renou, Sharmilla Sagnier, Mathieu Zuber, Ruben Tamazyan, Gilles Rodier, Sandra Felix, Wilfried Vadot, Valérie Wolff, Bertrand Yalo, Daniela Bindila, Véronique Quenardelle, Karine Blanc‐Lasserre, Emmanuelle Landrault, Ludovic Breynaert, Serkan Cakmak, Stéphane Peysson, Alain Viguier, Claire Lebely, Nicolas Raposo, Anne‐Evelyne Vallet, Pauline Vallet, Sébastian Brugirard, Bharath Kumar Cheripelli, Dheeraj Kalladka, Fiona Catherine Moreton, Krishna Dani, Salwa El Tawil, Sankaranarayanan Ramachandran, Xuya Huang, E Warburton, Nicholas R. Evans, Richard J. Perry, Bhavni Patel, Geoffrey C. CLOUD, Anthony C. Pereira, Barry Moynihan, Caroline E. Lovelock, Lillian Choy, Usman Khan, Christine Roffe, Pippa Tyrell, Craig J. Smith, Anand K. Dixit, Stephen Louw, David Broughton, Ashit K. Shetty, Jason P. Appleton, Nikola Sprigg, Boris Raul Acosta, Cecile van Eendenburg, Joaquín Serena Leal, Mikel Terceño Izaga, Olga Belchí Guillamon, Juan Francisco Arenillas, Ana Isabel Calleja, Elisa Cortijo, Patricia Mulero, Natàlia Pérez de la Ossa, Alícia Garrido, Alicia Martínez, Carlos García Esperón, Cristina Guerrero, David Vinicio Carrera-Villacrés, Dolores Vilas, Elena López‐Cancio, Ernest Palomeras, Giuseppe Lucente, Meritxell Gomis, Irina Isern, Juan Luís Becerra, Jose Hervas Vicente, J.A. Vidal Sánchez, Laura Dorado, Laia Grau, Lourdes Ispierto, Luís Prats, Míriam Almendrote, María Hernández‐Pérez, Marta Jiménez, Manuel Sanchez, Mónica Millán Torné, Silvia Presas, Xavier Ustrell, Anna Pellisé, Irene Navalpotro, Wouter J. Schonewille, Paul J. Nederkoorn, Charles B.L.M. Majoie, Lucie van den Berg, Sophie Berg, Thomas P. Zonneveld, Michel J. M. Remmers, Franz Fazekas, Alexander Pichler, Simon Fandler‐Höfler, Thomas Gattringer, Johannes Sebastian Mutzenbach, Jörg Weber, Elmar Höfner, Heinz Kohlfürst, Karin Weinstich, Lars Kellert, Anna Bayer-Karpinska, Christian Opherk, Frank Arne Wollenweber, Matthias Klein, Tobias Neumann‐Haefelin, Alexandra Pierskalla, Andreas Harloff, Juergen Bardutzky, Florian Buggle, Jörg Schrader, Rainer Kollmar, Josef Schill, Anna-Mareike Löbbe, Thierry Moulin, Benjamin Bouamra, Louise Bonnet, Emmanuel Touzé, Anne‐Laure Bonnet, Julien Cogez, Lin Li, Sophie Guettier, Arindam Kar, Aravinth Sivagnanaratham, Olivia C. Geraghty, Urszula Bojaryn, Arumugam Nallasivan, Miguel Blanco Gonzales, Manuel Rodríguez‐Yáñez, José Ignacio Tembl, David Górriz, Stefan Oberndorfer, Elisabeth Prohaska

22Citations signalées, ce qui n’est pas une note de qualité

21Institutions déclarées

8Pays d’affiliation déclarés

Rattachement africain : de, fr, be, nl, es, au, gb, dk. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Background and Purpose— Relative signal intensity of acute ischemic stroke lesions in fluid-attenuated inversion recovery (fluid-attenuated inversion recovery relative signal intensity [FLAIR-rSI]) magnetic resonance imaging is associated with time elapsed since stroke onset with higher intensities signifying longer time intervals. In the randomized controlled WAKE-UP trial (Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke Trial), intravenous alteplase was effective in patients with unknown onset stroke selected by visual assessment of diffusion weighted imaging fluid-attenuated inversion recovery mismatch, that is, in those with no marked fluid-attenuated inversion recovery hyperintensity in the region of the acute diffusion weighted imaging lesion. In this post hoc analysis, we investigated whether quantitatively measured FLAIR-rSI modifies treatment effect of intravenous alteplase. Methods— FLAIR-rSI of stroke lesions was measured relative to signal intensity in a mirrored region in the contralesional hemisphere. The relationship between FLAIR-rSI and treatment effect on functional outcome assessed by the modified Rankin Scale (mRS) after 90 days was analyzed by binary logistic regression using different end points, that is, favorable outcome defined as mRS score of 0 to 1, independent outcome defined as mRS score of 0 to 2, ordinal analysis of mRS scores (shift analysis). All models were adjusted for National Institutes of Health Stroke Scale at symptom onset and stroke lesion volume. Results— FLAIR-rSI was successfully quantified in stroke lesions in 433 patients (86% of 503 patients included in WAKE-UP). Mean FLAIR-rSI was 1.06 (SD, 0.09). Interaction of FLAIR-rSI and treatment effect was not significant for mRS score of 0 to 1 ( P =0.169) and shift analysis ( P =0.086) but reached significance for mRS score of 0 to 2 ( P =0.004). We observed a smooth continuing trend of decreasing treatment effects in relation to clinical end points with increasing FLAIR-rSI. Conclusions— In patients in whom no marked parenchymal fluid-attenuated inversion recovery hyperintensity was detected by visual judgement in the WAKE-UP trial, higher FLAIR-rSI of diffusion weighted imaging lesions was associated with decreased treatment effects of intravenous thrombolysis. This parallels the known association of treatment effect and elapsing time of stroke onset.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Quantitative Signal Intensity in Fluid-Attenuated Inversion Recovery and Treatment Effect in the WAKE-UP Trial
Date Crossref: 01/01/2020
Éditeur: Ovid Technologies (Wolters Kluwer Health)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Universität Hamburg pays non établi dans la notice
Université ou école supérieure
University Medical Center Hamburg-Eppendorf G.T.) pays non établi dans la notice
Établissement de santé
Klinik und Poliklinik für Neurologie pays non établi dans la notice
Établissement de santé
Lyon 1 Université pays non établi dans la notice
Université ou école supérieure
Centre National de la Recherche Scientifique pays non établi dans la notice
Organisme public
Hospices Civils de Lyon pays non établi dans la notice
Établissement de santé
Laboratoire de Biométrie et Biologie Evolutive pays non établi dans la notice
Structure de recherche
VIB-KU Leuven Center for Cancer Biology pays non établi dans la notice
Structure de recherche
Amsterdam University Medical Centers pays non établi dans la notice
Établissement de santé
VIB-KU Leuven Center for Brain & Disease Research pays non établi dans la notice
Structure de recherche
KU Leuven Department of Neurosciences pays non établi dans la notice
Université ou école supérieure
Inserm pays non établi dans la notice
Organisme public

Universität Hamburg, G.T.) — University Medical Center Hamburg-Eppendorf et Klinik und Poliklinik für Neurologie, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Acute Ischemic Stroke ManagementCerebrovascular and Carotid Artery DiseasesAdvanced MRI Techniques and Applications

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