Valentin Held

Emotion Regulation in Functional Neurological Disorder: A Multimethod Comparison of Intra- and Interpersonal Strategies

Inga Niedtfeld, Johanna Hepp, Sabine Schellhaas, Astrid Steffen-Klatt et autres

OBJECTIVE: Emotion regulation (ER) difficulties are frequently reported in individuals with Functional Neurological Disorder (FND), yet most evidence derives from self-report data, and little is known about intra- and interpersonal ER preference and success under controlled conditions. METHODS: In a preregistered multimethod …

Civic listening: A social capital perspective on civic wealth creation.

Valentin Held, Guillermo Casasnovas

Emotion Regulation in Functional Neurological Disorder: A Multimethod Comparison of Intra- and Interpersonal Strategies

Valentin Held, Inga Niedtfeld, Dominik Klaasen van Husen, Sabine Schellhaas et autres

Objective: Emotion regulation (ER) difficulties are frequently reported in individuals with Functional Neurological Disorder (FND), yet most evidence derives from self-report data, and little is known about intra- and interpersonal ER preference and success under controlled conditions. Methods: In a multimethod design, …

Immune cell profiling reveals expanded stem cell–like memory T cells in anti-GAD65-associated neurological syndromes

Sumanta Barman, Saskia Räuber, Katharina Eisenhut, Daniela Esser et autres

The immunopathogenesis of autoimmune neurological syndromes (AINS) with antibodies against the 65 kDa isoform of glutamic acid decarboxylase (anti-GAD65 AINS) remains poorly understood. To elucidate underlying disease mechanisms and identify relevant cell populations, we performed single-cell RNA and immune repertoire sequencing of …

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Reduced Hospital Incidence of Autoimmune Encephalitis During the COVID-19 Pandemic

Jonathan Wickel, Ha‐Yeun Chung, Franz Felix Konen, Rosa Rössling et autres

OBJECTIVES: The aim of this study was to analyze changes in hospital incidence cases and disease severity of autoantibody-associated autoimmune encephalitis (AE) during the COVID-19 pandemic compared with the prepandemic period. METHODS: A retrospective multicenter study analyzed data from 24 centers within …

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Risk of Epilepsy and Factors Associated With Time to Seizure Remission in Anti-LGI1 Encephalitis

Tobias R. Baumgartner, Moritz Freyberg, Lucia Campetella, Yvette S. Crijnen et autres

BACKGROUND AND OBJECTIVES: Autoimmune encephalitis (AIE) with anti-leucine-rich glioma-inactivated 1 (LGI1) antibodies typically manifests with subacute cognitive deficits, seizures, and psychiatric symptoms, mostly in older adults. Immunotherapy (IT) leads to the cessation of seizures in most patients, yet some develop AIE-associated epilepsy …

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Early Treatment With Intravenous Immunoglobulins and Outcomes of Patients With Anti-IgLON5 Disease

Thomas Grüter, Carles Gaig, Yvette S. Crijnen, Maarten J. Titulaer et autres

Importance: Anti-IgLON5 disease is an autoimmune encephalopathy that often leads to severe disability or death. The efficacy of immunotherapy remains unknown. Objective: To investigate whether early immunotherapy is associated with disability and death in anti-IgLON5 disease. Design, Setting, and Participants: This retrospective, …

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Comorbidities and Their Influence on Outcomes and Infectious Complications in Autoimmune Encephalitis

Amelie Bohn, Klemens Angstwurm, Christian G. Bien, Kathrin Doppler et autres

BACKGROUND AND OBJECTIVES: Comorbidities greatly influence the course of many diseases. However, systematic data on comorbidities in patients with autoimmune encephalitis (AE) are scarce. We aimed to characterize comorbidities in patients with common AE variants and assess their influence on outcome and …

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Organizational Purpose and the Governance of Philanthropic Foundations

Valentin Held, Lisa K. Hehenberger

Organizations increasingly adopt purpose that goes beyond shareholder-wealth maximization and addresses a broader common good. At the same time there is growing recognition that purpose can mean different things to different actors. Existing research stresses the importance of governance to effectively deploy …

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Different pain phenotypes are associated with anti-Caspr2 autoantibodies

Patrik Greguletz, Maria Plötz, Carolin Baade‐Büttner, Christian G. Bien et autres

Autoantibodies against contactin-associated protein 2 (Caspr2) not only induce limbic autoimmune encephalitis but are also associated with pain conditions. Here, we analyzed clinical data on pain in a large cohort of patients included into the German Network for Research in Autoimmune Encephalitis. …

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The effects of COVID-19 on the vestibular system

Lena Zaubitzer, Sonja Ludwig, Michelle Berkemann, Beatrice Walter et autres

Introduction: The symptoms and severity of SARS-CoV-2 infection vary greatly across the spectrum, from asymptomatic infection to severe pneumonia with acute respiratory distress syndrome and even death. Dizziness is a frequently reported symptom of SARS-CoV-2 viral infection. However, the extent to which …

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Genetic overlap between dystonia and other neurologic disorders: A study of 1,100 exomes

Ivana Dzinovic, Sylvia Boesch, Matěj Škorvánek, Ján Necpál et autres

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