Juliane Herm

Teleneurology vs On-Site Neurology Consultation for Postadmission Hospital Care of Stroke

Janina Behrens, Maximilian Kaffes, Annette Aigner, Juliane Herm et autres

Importance: Telestroke networks provide coverage of neurological expertise in rural areas. While most teleneurological consultations focus on acute stroke care in emergency departments, neurological expertise remains crucial in the subacute phase. However, teleneurological ward rounds have not yet been systematically investigated for …

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Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the Central Nervous System —A Multicenter Cohort Study in 163 Patients

Anna Lena Fisse, Nadine Bonberg, Carolin Beuker, Claudia Pfeuffer et autres

OBJECTIVE: The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. METHODS: In a retrospective, observational cohort study, we analyzed 163 adult …

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Biopsy-proven PACNS: results from the large, multicentre cohort of cerebral vasculitis patients

Milani Deb‐Chatterji, Parnia Aghel, Hans O. Pinnschmidt, Christina Krüger et autres

BACKGROUND: Reports of primary angiitis of the central nervous system (PACNS) are mainly restricted to clinically suspected cases, but biopsy-proven ones are rare. Here, we present results from a large multicentre cohort of patients with biopsy-proven PACNS (BP-PACNS). In particular, we provide …

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Assessing non-inferiority for binary matched-pairs data with missing values: a powerful and flexible GEE approach based on the risk difference

Johannes Hengelbrock, Frank Konietschke, Juliane Herm, Heinrich J. Audebert et autres

BACKGROUND: Clinical studies often aim to test the non-inferiority of a treatment compared to an alternative intervention with binary matched-pairs data. These studies are often planned with methods for completely observed pairs only. However, if missingness is more frequent than expected or …

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VISIT STROKE: non-inferiority of telemedicine-based neurological consultation for post-acute stroke patients – protocol of a prospective observational controlled multi-center study

Juliane Herm, Hebun Erdur, Annette Aigner, Johannes Hengelbrock et autres

BACKGROUND: Telemedicine provides specialized medical expertise in underserved areas where neurological expertise is frequently not available on a daily basis for hospitalized stroke patients. While tele-consultations are well established in acute stroke assessment, the value of telemedicine-based ward-rounds in the subsequent in-patient …

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Heart rate turbulence in acute ischemic stroke

Helena Stengl, Ramanan Ganeshan, Regina von Rennenberg, Simon Hellwig et autres

BACKGROUND: Heart rate turbulence (HRT), an ECG-based marker of autonomic cardiac regulation, has shown high prognostic value in patients with established cardiovascular diseases, while data in patients with acute ischemic stroke are scarce. PATIENTS AND METHODS: The HRT parameters turbulence onset and …

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Enhanced diagnostic workup increases pathological findings in patients with acute ischaemic stroke: results of the prospective HEBRAS study

Simon Hellwig, Thomas Krause, Jan F. Scheitz, Juliane Herm et autres

BACKGROUND: Stroke aetiology remains cryptogenic in a relevant proportion of patients with acute ischaemic stroke (AIS). We assessed whether enhanced diagnostic workup after AIS yields a higher rate of prespecified pathological findings compared with routine diagnostic care in-hospital. METHODS: Hospitalised patients with …

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Ability of patients with acute ischemic stroke to recall given information on intravenous thrombolysis: Results of a prospective multicenter study

Luzie Katharina Schuster, Fabian Essig, Naeimeh Daneshkhah, Juliane Herm et autres

Abstract Introduction: Intravenous thrombolysis (IVT) is an on label treatment for selected patients with acute ischemic stroke (AIS). As major bleeding or allergic shock may occur, the need to ensure patients’ informed consent for IVT is a matter of debate. Patients and …

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Elevation of cardiac biomarkers in stroke is associated with pathological findings on cardiac MRI—results of the HEart and BRain interfaces in Acute Stroke study

Regina von Rennenberg, Juliane Herm, Thomas Krause, Simon Hellwig et autres

Introduction: Cardiac biomarkers, such as high-sensitivity cardiac troponin T (hs-cTnT), are frequently elevated in ischemic stroke patients but the mechanisms underlying this elevation are insufficiently understood. We determined the presence of cardiac damage, assessed using cardiac magnetic resonance imaging (CMR), in stroke …

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Sequential treatment of progressive multifocal leukoencephalopathy with intravenous immunoglobulins and pembrolizumab

Fabian Boesl, Kristina Allers, Juliane Herm, T. Scheider et autres

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the CNS caused by the human polyomavirus 2 (JCV). PML predominantly occurs in immunocompromised patients. To date, no specific antiviral treatment exists, leaving only restoration of the immune system as possible treatment. …

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Ability of Patients with Acute Ischemic Stroke to Recall Given Information on Intravenous Thrombolysis – Results of a Prospective Multicenter Study

Luzie Katharina Schuster, Fabian Essig, Naeimeh Daneshkhah, Juliane Herm et autres

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Heart Rate Variability and Recurrent Stroke and Myocardial Infarction in Patients With Acute Mild to Moderate Stroke

Regina von Rennenberg, Thomas Krause, Juliane Herm, Simon Hellwig et autres

Objectives: In patients with acute ischemic stroke, reduced heart rate variability (HRV) may indicate poor outcome. We tested whether HRV in the acute phase of stroke is associated with higher rates of mortality, recurrent stroke, myocardial infarction (MI) or functional outcome. Materials …

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