Accès ouvert déclaré 2019 preprint

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

Melissa A. Munn‐Chernoff, Emma C. Johnson, Yi‐Ling Chou, Jonathan R. I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yılmaz, Jessica H. Baker, Christopher Hübel, Scott D. Gordon, Sarah E. Medland, Hunna J. Watson, Héléna A. Gaspar, Julien Bryois, Anke Hinney, Virpi Leppä, Manuel Mattheisen, Stephan Ripke, Shuyang Yao, Paola Giusti‐Rodríguez, Ken B. Hanscombe, Roger A.H. Adan, Lars Alfredsson, Tetsuya Ando, Ole A. Andreassen, Wade H. Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D. Cone, Philippe Courtet, Scott J. Crow, James J. Crowley, Unna N. Danner, Oliver S. P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak‐Węglarz, Elisa Docampo, Laramie E. Duncan, Karin Egberts, Stefan Ehrlich, Geòrgia Escaramís, Tõnu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernández‐Aranda, Manfred M. Fichter, Krista Fischer, Manuel Föcker, Lenka Foretová, Andreas J. Forstner, Monica Forzan, Christopher S. Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sébastien Guillaume, Yiran Guo, Håkon Håkonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G. Helder, Stefan Herms, Beate Herpertz‐Dahlmann, Wolfgang Herzog, Laura M. Huckins, James I. Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimír Janout, Susana Jiménez‐Múrcia, Antonio Julià, Gursharan Kalsi, Deborah Kaminská, Leila Karhunen, Andreas Karwautz, Martien J. Kas, James L. Kennedy, Anna Keski‐Rahkonen, Kirsty Kiezebrink, Youl‐Ri Kim, Kelly L. Klump, Gun Peggy Knudsen, Maria C. La Via, Stéphanie Le Hellard, Robert D. Levitan, Dong Li, Lisa Lilenfeld, Bochao Lin, Jolanta Lissowska, Jurjen J. Luykx, Pierre J. Magistretti, Mario Maj, Katrin Männik, Sara Marsal, Christian R. Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen S. Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Benedetta Nacmias, Marie Navratilova, Ιωάννα Ντάλλα, Julie K. O’Toole, Roel A. Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papežová, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolás Ramoz, Ted Reichborn‐Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, André Scherag, Stephen W. Scherer, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Šlachtová, P. Eline Slagboom, M Landt, Agnieszka Slopien, Sandro Sorbi, Beata Świątkowska, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Άρτεμις Τσίτσικα, Marta Tyszkiewicz‐Nwafor, Konstantinos Tziouvas, Annemarie Elburg, Eric F. van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widén, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W. Bergen, Joseph M. Boden, Harry Brandt, Steven Crawford, Katherine A. Halmi, L. John Horwood, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, James E. Mitchell, Catherine M. Olsen, John F. Pearson, Nancy L. Pedersen, Michael Strober, Thomas Werge, David C. Whiteman, D. Blake Woodside, Jakob Grove, Anjali K. Henders, Janne Tidselbak Larsen, Richard Parker, Liselotte Petersen, Jennifer Jordan, Martin A. Kennedy, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Mikael Landén, Preben Bo Mortensen, Renato Polimanti, Jeanette N. McClintick, Amy Adkins, Fazil Alıev, Silviu‐Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li‐Shiun Chen, Toni‐Kim Clarke, Franziska Degenhardt, Anna R. Docherty, Alexis C. Edwards, Jerome C. Foo, Louis Fox, Josef Frank, Laura M. Hack, Annette M. Hartmann, Sarah M. Hartz, Stefanie Heilmann‐Heimbach, Colin A. Hodgkinson, Per Hoffmann, Jouke‐Jan Hottenga, Bettina Konte, Jari Lahti, Marius Lahti‐Pulkkinen, Dongbing Lai, Lannie Ligthart, Anu Loukola, Brion S. Maher, Hamdi Mbarek, Andrew M. McIntosh, Matthew B. McQueen, Jacquelyn L. Meyers, Yuri Milaneschi, Teemu Palviainen, Roseann E. Peterson, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Sandra Sanchez‐Roige, Melanie L. Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen‐Chyong Wang, Bradley T. Webb, Robbee Wedow, Leah Wetherill, Amanda G. Wills, Hang Zhou, Danfeng Chen, Doo‐Sup Choi, William Copeland, Robert Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W. Domingue, Mark A. Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret A. Keyes, Falk Kiefer, G. Koller, John R. Kramer, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller‐Myhsok, Alison D. Murray, John I. Nürnberger, Ulrich W. Preuss, Katri Räikkönen, Maureen Reynolds, Monika Ridinger, Norbert Scherbaum, Marc A. Schuckit, Michael Soyka, Jens Treutlein, Stephanie H. Witt, Norbert Wodarz, Peter Zill, Daniel E. Adkins, Dorret I. Boomsma, Laura J. Bierut, Sandra A. Brown, Kathleen K. Bucholz, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Johan G. Eriksson, Lindsay A. Farrer, Tatiana Foroud, Nathan A. Gillespie, Alison Goate, David Goldman, Richard A. Grucza, Dana B. Hancock, Kathleen Mullan Harris, Victor Hesselbrock, John K. Hewitt, Christian J. Hopfer, William G. Iacono, Eric O. Johnson, Victor M. Karpyak, Kenneth S. Kendler, Henry R. Kranzler, Kenneth Krauter, Penelope A. Lind, Matt McGue, James MacKillop, Pamela A. F. Madden, Hermine H. Maes, Patrik K. E. Magnusson, Elliot C. Nelson, Markus M. Nöthen, Abraham A. Palmer, Brenda W.J.H. Penninx, Bernice Porjesz, John P. Rice, Marcella Rietschel, Brien P. Riley, Richard J. Rose, Pei‐Hong Shen, Judy L. Silberg, Michael C. Stallings, Ralph E. Tarter, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, John B. Whitfield, Hongyu Zhao, Benjamin M. Neale, Tracey Wade, Andrew C. Heath, Grant W. Montgomery, Nicholas G. Martin, Patrick F. Sullivan, Jaakko Kaprio, Gerome Breen, Joel Gelernter, Howard J. Edenberg, Cynthia M. Bulik, Arpana Agrawal

15Citations signalées, ce qui n’est pas une note de qualité

195Institutions déclarées

25Pays d’affiliation déclarés

Rattachement africain : us, no, gb, se, au, de, dk, nl, jp, cz, fr, hr, it, ch, gr, pl, es, ee, ca, fi, at, kr, sa, ie, nz. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

Abstract Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa (BN) and problem alcohol use (genetic correlation [ r g ], twin-based=0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge-eating, AN without binge-eating, and a BN factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder (MDD). Total sample sizes per phenotype ranged from ~2,400 to ~537,000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN ( r g =0.18; false discovery rate q =0.0006), cannabis initiation and AN ( r g =0.23; q <0.0001), and cannabis initiation and AN with binge-eating ( r g =0.27; q =0.0016). Conversely, significant negative genetic correlations were observed between three non-diagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge-eating ( r gs =-0.19 to −0.23; qs <0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for MDD loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships between these behaviors.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies
Date Crossref: 23/08/2019
Éditeur: openRxiv
Type: posted-content

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Les institutions déclarées

University of North Carolina at Chapel Hill Oslo University Hospital Washington University in St. Louis National Health Service King's College London National Institute for Health and Care Research Broad Institute Harvard University Massachusetts General Hospital Massachusetts Institute of Technology Karolinska Institutet QIMR Berghofer Medical Research Institute The University of Western Australia Curtin University Essen University Hospital University of Duisburg-Essen Aarhus University University of Würzburg Region Stockholm Stockholm Health Care Services Charité - Universitätsmedizin Berlin Guy's Hospital King's College Hospital University Medical Center Utrecht Altrecht GGZ University of Gothenburg National Center of Neurology and Psychiatry National Institute of Mental Health National Institute of Mental Health University of Oslo Normandie Université University of Pennsylvania Technische Universität Dresden Inserm Wellcome Sanger Institute University of Split RWTH Aachen University Klinikum Frankfurt Höchst University of Padua Department of Biomedicine Basel Forschungszentrum Jülich University of Basel South London and Maudsley NHS Foundation Trust University Hospital of Basel University of Michigan Université de Montpellier University of Minnesota University of Bristol MRC Epidemiology Unit Medizinische Hochschule Hannover Harokopio University of Athens Seattle University Virginia Commonwealth University Centre National de la Recherche Scientifique Institut du Thorax Poznan University of Medical Sciences Universitat Pompeu Fabra Barcelona Institute of Science and Technology Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública Stanford University Universitätsklinikum Würzburg University of Tartu Centre for Genomic Regulation Institut d'Investigació Biomédica de Bellvitge Centro de Investigación Biomédica en Red Universitat de Barcelona Schön Klinik Roseneck Ludwig-Maximilians-Universität München University of Münster Masaryk Memorial Cancer Institute University of Bonn Philipps University of Marburg University Hospital Bonn University of Toronto Martin Luther University Halle-Wittenberg National and Kapodistrian University of Athens Eginition Hospital Université Paris Cité Institut de Psychiatrie et Neurosciences de Paris Children's Hospital of Philadelphia Helmholtz Munich Heidelberg University University Hospital Heidelberg Icahn School of Medicine at Mount Sinai McLean Hospital Werner-Wicker-Klinik Tokai University Palacký University Olomouc Vall d'Hebron Institut de Recerca Charles University University of Eastern Finland Medical University of Vienna University of Groningen Centre for Addiction and Mental Health University of Helsinki University of Aberdeen Inje University Seoul Paik Hospital Michigan State University Norwegian Institute of Public Health Haukeland University Hospital University of Bergen The Chicago School The Maria Sklodowska-Curie National Research Institute of Oncology Centre Hospitalier Universitaire Vaudois King Abdullah University of Science and Technology University of Lausanne University of Campania "Luigi Vanvitelli"Hospital for Sick Children University College Cork Health Service Executive Leiden University Medical Center University of Geneva University Hospital of Geneva VA Boston Healthcare System National Center for PTSD University of Salerno University of Florence Oregon Clinic University of California, Los Angeles Erasmus MC Karolinska University Hospital Institute for Molecular Medicine Finland Hospital Sant Joan de Déu Barcelona University of Pisa Jena University Hospital J. Craig Venter Institute GGZ Rivierduinen Don Carlo Gnocchi Foundation Nofer Institute of Occupational Medicine University of Perugia University of Naples Federico II Panagiotis & Aglaia Kyriakou Children's Hospital Utrecht University Oregon Research Institute BioRealm (United States)University of Otago Sheppard and Enoch Pratt Hospital Cornell University The Recovery Center University of California San Diego University of North Dakota University of Copenhagen University Health Network Lundbeck Foundation The University of Queensland Canterbury District Health Board Yale University VA Connecticut Healthcare System Indiana University School of Medicine Indiana University – Purdue University Indianapolis Mayo Clinic Mayo Clinic in Florida State University of New York SUNY Downstate Health Sciences University University of Edinburgh University of Utah Central Institute of Mental Health National Institutes of Health National Institute on Alcohol Abuse and Alcoholism Vrije Universiteit Amsterdam University of Turku Johns Hopkins University University of Colorado Boulder GGZ inGeest Office of the Director Boston University Harvard University Press University of Colorado Denver WinnMed University of Vermont Medical Center Johannes Gutenberg University Mainz UNSW Sydney Heinrich Heine University Düsseldorf Institute of Genetics and Cancer Max Planck Institute of Psychiatry LMU Klinikum University of Iowa Finnish Institute for Health and Welfare Vitos University of Pittsburgh University of Regensburg Duke Medical Center Duke University Hospital University of Chicago Office of Extramural Research RTI International University of Connecticut Mental Illness Research, Education and Clinical Centers Philadelphia VA Medical Center VA Healthcare-VISN 4 St. Joseph’s Healthcare Hamilton McMaster University Amsterdam University Medical Centers Indiana University Bloomington Flinders University

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Les sujets associés

Eating Disorders and BehaviorsObesity, Physical Activity, DietGenetic Associations and Epidemiology

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