Accès ouvert déclaré
2007
article
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Paul Robert Burton, David G Clayton, L. R. Cardon, Nick J. Craddock, Panos Deloukas, Audrey Duncanson, Dominic P. Kwiatkowski, Mark I. McCarthy, Willem Hendrik Ouwehand, Nilesh J. Samani, Jennifer A. Todd, Peter Donnelly, J C Barrett, D B Davison, Douglas F. Easton, David M. Evans, H. T. T. Leung, Jonathan Marchini, A. P. Morris, Chris C. A. Spencer, Martin D. Tobin, Antony Attwood, James P. Boorman, B. Cant, Ursula Everson, Judith M. Hussey, Jennifer D. Jolley, Alexandra S. Knight, K. Koch, Elizabeth Meech, Sarah L. Nutland, C V Prowse, H. E. Stevens, Natalie Taylor, G. R. Walters, N Walker, Nicholas A. Watkins, Thilo Winzer, Richard Wyn Jones, Wendy L. McArdle, Susan M. Ring, D. P. Strachan, Marcus E Pembrey, Gerome D. Breen, David St Clair, Sian Caesar, Katherine Gordon‐Smith, Lynn Jones, Christine Fraser, E. K. Green, Detelina Grozeva, Marian L. Hamshere, Peter Holmans, Ian R. Jones, George Kirov, Valentina Moskivina, Ivan Nikolov, Michael C. O’Donovan, M J Owen, David Andrew Collier, Amanda Elkin, Andrew D Farmer, Richard Williamson, Peter McGuffin, Aaron Young, I. Nicol Ferrier, Steve G. Ball, Anthony J. Balmforth, Jennifer H. Barrett, D. Timothy Bishop, Mark Martin Iles, Azhar Maqbool, N. Yuldasheva, Ashley Hall, Peter S. Braund, Richard J. Dixon, Massimo Mangino, Suzanne Stevens, John Russell Thompson, Fran Bredin, Mark Tremelling, Miles Parkes, Hazel E. Drummond, Charlie W. Lees, Elaine R. Nimmo, Jack Satsangi, Scott A. Fisher, Alastair Forbes, Cathryn M. Lewis, C. M. Onnie, Natalie J. Prescott, J Sanderson, Christopher G Matthew, Julie M. Barbour, Mohamed Khalid Mohiuddin, CE Todhunter, J. Mansfield, Tavsief Ahmad, F Cummings, D. P. Jewell, Jennifer Webster, M. J. Brown, M Lathrop, Jmc Connell, Anna F. Dominiczak, C Marcano, Brian K. Burke, Ruth Dobson, Johannie Gungadoo, Katie Lee, Patricia B. Munroe, Stephen Newhouse, Abiodun K. Onipinla, Chris Wallace, Min Feng Xue, Mark J. Caulfield, Martin Farrall, Anne C Barton, Ian N Bruce, Hannah Donovan, Stephen Eyre, Paul Gilbert, Samantha L Hilder, A. M. Hinks, Sheila John, Catherine Potter, Alan J. Silman, Deborah P. M. Symmons, Wendy Thomson, Jane Worthington, David B. Dunger, Barry Widmer, Timothy Mark Frayling, Rachel M. Freathy, Hana Lango Allen, John R. B. Perry, Beverly M. Shields, Michael N. Weedon, Andrew Tym Hattersley, G. A. Hitman, M R Walker, K. S. Elliott, Christopher J. Groves, Cecilia M. Lindgren, N W Rayner, Nicholas John Timpson, Eleftheria Zeggini, Melanie J. Newport, Giorgio Sirugo, Elizabeth A Lyons, Fredrick O Vannberg, Adrian V. S. Hill, L Bradbury, C. Farrar, J. J. Pointon, P Wordsworth, Matthew A. Brown, JayneA Franklyn, Joanne M. Heward, Matthew J. Simmonds, Stephen C. L. Gough, Souvik Seal, Michael R. Stratton, Nazneen Rahman, Matthew R. Ban, An Goris, Stephen J sawcer, A. Compston, David J. Conway, Muminatou Jallow, Kirk A. Rockett, S. J. Bumpstead, Amy Chaney, Kate Downes, M. J. R. Ghori, Rhian Gwilliam, S. E. Hunt, Michael Inouye, Andrew Keniry, Elizabeth G. King, Ralph E. McGinnis, Sally Potter, Rathi Ravindrarajah, Pamela Whittaker, Claire Widden, David Withers, Niall J. Cardin, Teresa Cruz Ferreira, Joanne Pereira-Gale, Ingileif B. Hallgrímsdóttir, Bryan Howie, Zhan Su, Yik‐Ying Teo, Damjan Vukcevic, D. Bentley, Sabrina L. Mitchell, Paul Newby, Stephan Brand, Jackie Carr‐Smith, Simon H. S. Pearce, John D. Reveille, Xia Zhou, A. M. Sims, Alison Dowling, Joy L. Taylor, Tracy Doan, Jacob Davis, Laurie Savage, M. M. Ward, Thomas L Learch, Michael H. Weisman
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Le résumé fourni par la source
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid disease (AITD), multiple sclerosis (MS) and breast cancer (BC). Comparing these data against a common control dataset derived from 1,500 randomly selected healthy British individuals, we report initial association and independent replication in a North American sample of two new loci related to ankylosing spondylitis, ARTS1 and IL23R, and confirmation of the previously reported association of AITD with TSHR and FCRL3. These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases.
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