DIALYSIS BONE DISEASE
Rattachement africain : jp, be, gb, sa, it, de, cn, pl, at, ae, kw, us, qa, om, bh. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction and Aims: Vertebral Fractures (VFs) are common in the general population and in Chronic Kidney Disease patients.VFs are associated with vascular calcifications (VCs) and to an increased risk of mortality.The Spine Deformity Index (SDI) is a summary measure of the VFs status, incorporating both the number and severity of VFs in a score.The aim of this study was to evaluate the relationships between the classic SDI, laboratory parameters of bone metabolism, and vascular calcifications within the context of the EVERFRACT study.Methods: In 387 hemodialysis patients, aged 64.2 ± 14.1 years, we determined routine biochemical parameters and: 25(OH)vitamin D, total Bone Gla Protein (BGP), undercarboxylated BGP (ucBGP) and total Matrix Gla Protein (MGP).We performed laterolateral x-Rays of the spine (T5 to L4) to evaluate both VFs (defined as reduction > 20% in vertebral body height) by Quantitative Vertebral Morphometry and VCs, aortic (AoVC) and iliac (IaVC), by Witteman's method.We divided the SDI score by the number of fractures, in order to obtain a more precise index of fracture severity (corrected-SDI: c-SDI).Results: We found a high prevalence (55.3%, n=214) of VFs.The mean SDI was 1.4 ± 1.74.The mean c-SDI was 0.74 ± 0.75.VFs had a grade of severity that was low through T5-T10 and higher through T11-L3.The severity of fractures was highlighted only by c-SDI (see Table ).We found 80.6% of AAoC and 55.6% of IAC.SDI was significantly associated with AAoC (OR=1.15,95% CI 1.02-1.30,p=0.023).A SDI >1 was significantly associated with: sex (male OR 1.86, 95% CI 1.20-2.91,p=0.007), age (OR 1.03, 95% 1.01-1.05,p=0.0003) and albumin ≥ 3.5 g/dL (OR 0.54, 95% CI 0.31-0.93,p=0.026).c-SDI score was significantly associated with AAoC (OR=1.48,95% CI 1.11-1.98,p=0.0009) and with IAC (OR=1.54,95% CI 1.06-2.24,p=0.025).A c-SDI >1 was significantly associated with: age (OR 1.05, 95% CI 1.03-1.07,p<0.0001),LDL Cholesterol ≥ 90 mg/dL (OR 1.74, 95% 1.04-2.92,p=0.0354) and ucBGP ≥ 17.2 mcg/L (OR 0.35, 95% CI 0.18-0.70,p=0.0025).Conclusions: SDI and c-SDI score associated with bone and vascular markers.c-SDI score performed better in the evaluation of the grade of fracture severity and it showed a stronger association with VC and vascular markers.This is the first time that the association of SDI with bone biochemical parameters and VC has been reported.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- DIALYSIS BONE DISEASE
- Date Crossref
- 01/05/2014
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
SHOWA Medical University pays non établi dans la noticeUniversité ou école supérieure
-
University of Antwerp pays non établi dans la noticeUniversité ou école supérieure
-
University Hospital of Wales pays non établi dans la noticeÉtablissement de santé
-
Osaka City University pays non établi dans la noticeUniversité ou école supérieure
-
Saudi Center for Organ Transplantation pays non établi dans la noticeOrganisme public
-
Neuroscience Institute pays non établi dans la noticeStructure de recherche
-
Klinikum Coburg pays non établi dans la noticeÉtablissement de santé
-
Air Force General Hospital PLA pays non établi dans la noticeÉtablissement de santé
-
Institute of Biocybernetics and Biomedical Engineering pays non établi dans la noticeStructure de recherche
-
Polish Academy of Sciences pays non établi dans la noticeOrganisme public
-
Medical University of Lublin pays non établi dans la noticeUniversité ou école supérieure
-
University of Padua Clinica Medica 1 pays non établi dans la noticeUniversité ou école supérieure
SHOWA Medical University, University of Antwerp et University Hospital of Wales, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.