Stefan Vegter

Methodological Challenges in the Economic Evaluation of a Gene Therapy for RPE65-Mediated Inherited Retinal Disease: The Value of Vision

Simone Huygens, Matthijs Versteegh, Stefan Vegter, L. Jan Schouten et autres

The emergence of gene therapies challenge health economists to evaluate interventions that are often provided to a small patient population with a specific gene mutation in a single dose with high upfront costs and uncertain long-term benefits. The objective of this study …

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Measuring quality of life in opioid-induced constipation: mapping EQ-5D-3 L and PAC-QOL

Anthony J. Hatswell, Stefan Vegter

BACKGROUND: In health economic evaluations, quality of life should be measured with preference-based utilities, such as the EuroQol 5 Dimension 3-level (EQ-5D-3 L). Non-preference-based instruments (often disease-specific questionnaires) are commonly mapped to utilities. We investigated if the relationship observed between the Patient …

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Economic Evaluations of Pharmacogenetic and Pharmacogenomic Screening Tests: A Systematic Review. Second Update of the Literature

E.J.J. Berm, Margot de Looff, Bob Wilffert, Cornelis Boersma et autres

OBJECTIVE: Due to extended application of pharmacogenetic and pharmacogenomic screening (PGx) tests it is important to assess whether they provide good value for money. This review provides an update of the literature. METHODS: A literature search was performed in PubMed and papers …

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Cost effectiveness of lanthanum carbonate in chronic kidney disease patients in Spain before and during dialysis

Blanca Gros, António Galán de Mera, Emilio González‐Parra, José Antonio Herrero et autres

AIMS: In Spain, the first line treatment of hyperphosphatemia in Chronic Kidney Disease (CKD) consists of calcium-based phosphate binders (CB). However, their use is associated with vascular calcification and an increased mortality risk. The aim of this study was to assess the …

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Does a cardiovascular event change adherence to statin treatment in patients with type 2 diabetes? A matched cohort design

Folgerdiena M. de Vries, Petra Denig, Stefan Vegter, H Bos et autres

OBJECTIVE: To be effective, adherence to statin treatment is essential. We assessed the effect of an apparent first cardiovascular event on statin adherence rates in type 2 diabetes patients. RESEARCH DESIGN AND METHODS: A matched cohort study was conducted among type 2 …

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The Impact of Disease Modification on the Cost-Effectiveness of Pegloticase for the Treatment of Severe Debilitating Chronic Tophaceous Gout In Adult Patients

K. Wallerstein, Keith Tolley, Stefan Vegter

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Mapping May Cause Straining: The Inconsistent Relationship Between A Disease- Specific Questionnaire (Pac-Qol) And Eq-5d Mapping In Constipation

Stefan Vegter, Anthony J. Hatswell

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Impact of multiple-dose versus single-dose inhaler devices on COPD patients’ persistence with long-acting β2-agonists: a dispensing database analysis

Job F. M. van Boven, Joost J van Raaij, Ruben van der Galiën, Maarten J. Postma et autres

BACKGROUND: With a growing availability of different devices and types of medication, additional evidence is required to assist clinicians in prescribing the optimal medication in relation to chronic obstructive pulmonary disease (COPD) patients' persistence with long-acting β2-agonists (LABAs). AIMS: To assess the …

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Therapietrouwbevordering COPD bespaart kosten

Job F. M. van Boven, Eline Tommelein, Els Mehuys, Koen Boussery et autres

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[Optimizing pharmacotherapy in patients with COPD by community-pharmacists: a cost-effectiveness analysis].

van Boven Jf, Eline Tommelein, Koen Boussery, Els Mehuys et autres

Therapietrouwbevordering lipidenverlagers is kosteneffectief: Kosteneffectiviteit bij primaire, kostenbesparing bij secundaire preventie

Stefan Vegter, Piter Oosterhof, Job F. M. van Boven, A.G.G. Stuurman-Bieze et autres

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Medication Monitoring and Optimization: A Targeted Pharmacist Program for Effective and Cost-Effective Improvement of Chronic Therapy Adherence

Job F. M. van Boven, A.G.G. Stuurman-Bieze, Eric Hiddink, Maarten J. Postma et autres

UNLABELLED: BACKGROUND: Community pharmacies provide a promising platform for monitoring and improving therapy adherence and providing pharmaceutical care. Structured methods and appropriate software are important tools to increase pharmacist effectiveness and improve health outcomes. In 2006, the Medication Monitoring and Optimization (MeMO) …

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